hypericum perforatum, St. John’s Wort

St. John’s Wort is a flowering plant native to Europe known for its nootropic properties, specially nootropic ones, which come from the active compound hyperforin. This herb is often used to treat depression and menopausal symptoms, and is beeing studied to help in anxiety, stress, menopause-related symptoms and appetite control.

  • Origin: Plant Based
  • Source: Itself
  • Type: Herbs, Roots & Barks
  • Age Range: Adults, Seniors
  • Toxicity: May be toxic in high doses
  • Outcomes: Cognitive Function and Brain Health, Energy and Mood, Women’s Health, Cognitive Enhancer, Anxiety, Depression, Menopause, PMS

What are St. John’s Wort benefits?

St. John’s wort (Hypericum perforatum) was widely used in ancient Greece for a variety of ailments, including various nervous disorders. The herb also has antibacterial, antioxidant, and antiviral substances. Because of its anti-inflammatory properties, it was used in the dermis to help heal wounds and burns. St. John’s wort is one of the most commonly purchased herbal products in the United States. In recent years, St. John’s wort has been studied as a treatment for symptoms of depression. Most studies show that St. John’s wort can help treat mild to moderate depression and has few side effects. But it does interact with several medications, so it should only be taken under the guidance of a doctor.

Table of relations

Consistent effects
Strength of effects
Scientific articles

Cognitive Function and Brain Health St. John’s Wort and Cognitive Function and Brain Health

Cognitive functions are brain skills divided into: memory, perception, language, executive functions, attention and praxis (ability to perform complex movements). These functions depend on healthy synapses and neurons, which require good overall brain functioning. Supplements can affect cognitive performance directly or indirectly. Direct effects can alter or participate in neurotransmissions and influence the brain's energy metabolism. The indirect effects include hormonal changes that affect the brain, and improvements in cognitive disorders such as anxiety, depression and insomnia.
  • Cognitive Enhancer

    Cognition encompasses many factors, such as thinking, language, perception, and memory. When talking about cognitive improvement, we define age-related decline in cognitive health as something common, however, knowing which habits negatively influence it and how to prevent any loss in these areas is important. In addition to age, factors such as injury, family history, or bad habits can influence the decline to some degree of the sectors involved. Several studies associate nutrition with the improvement of brain and cognitive function; the ingestion of nutraceuticals for this purpose optimizes this process and guarantees results with scientific proof.

Energy and Mood St. John’s Wort and Energy and Mood

Energy and mood are associated with several external and internal factors. Hormone release, brain chemical balance, nutrient metabolism, and several other elements alter the way the body and mind respond to daily activities. The compounds that benefit energy and mood are the ones that help in the balance of all these factors.
  • Anxiety

    Anxiety is the body's natural response to stress. It's a feeling of fear or apprehension about what's to come. It can be triggered by a specific situation and not last long - which is very common and ok - or it can be a generalized disorder (which is considered a illness) that can bring harm to everyday life and also cause other conditions like depression.

  • Depression

    Depression is a chronic and recurrent psychiatric condition that produces mood changes characterized by deep sadness, mood swings, loss of interest in activities, causing significant impairment in daily life.

Women's Health St. John’s Wort and Women's Health

The female body has specific physiological processes involving sex hormones, health of the ovaries, uterus and vagina, menstrual cycle, pregnancy and lactation and menopause. The compounds indicated for women's health assist in the synthesis and secretion of these hormones, in premenstrual and menopausal symptoms and in the protection of female sexual organs.
  • Menopause

    Menopause is a natural decline in reproductive hormones when a woman reaches around 50 years old. It causes uncorfortable symptoms but thay can me eased with certain medications and nutraceutics.

  • PMS

    Premenstrual syndrome (PMS) is a condition that affects a woman’s emotions, physical health, and behavior during certain days of the menstrual cycle, generally just before her menses. PMS is a very common condition. Its symptoms affect more than 90 percent of menstruating women. It must impair some aspect of your life for your doctor to diagnose you. PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown. However, many researchers believe that it’s related to a change in both sex hormone and serotonin levels at the beginning of the menstrual cycle. Levels of estrogen and progesterone increase during certain times of the month. An increase in these hormones can cause mood swings, anxiety, and irritability. Ovarian steroids also modulate activity in parts of your brain associated with premenstrual symptoms.

Table of negative interactions

Abemaciclib, Abiraterone, Acalabrutinib, Alpelisib, Amiodarone, Amitriptyline, Amoxapine, Amprenavir, Apixaban, Apremilast, Atazanavir, Avapritinib, Avatrombopag, Axitinib, Bedaquiline, Berotralstat, Boceprevir, Bortezomib, Bosutinib, Brigatinib, Buspirone, Butorphanol, Cabozantinib, Capmatinib, Ceritinib, Citalopram, Clomipramine, Cobicistat, Cobimetinib, Copanlisib, Crizotinib, Cyclobenzaprine, Cyclosporine, Dabigatran, Daclatasvir, Darolutamide, Darunavir, Dasatinib, Deflazacort, Delavirdine, Desipramine, Desvenlafaxine, Dexfenfluramine, Dolasetron, Dolutegravir, Doravirine, Doxepin, Doxepin Topical, Drospirenone, Duloxetine, Duvelisib, Efavirenz, Eliglustat, Elvitegravir, Encorafenib, Entrectinib, Eravacycline, Erdafitinib, Escitalopram, Etonogestrel, Etravirine, Everolimus, Fedratinib, Felodipine, Fenfluramine, Fentanyl, Finerenone, Flibanserin, Fluoxetine, Fluvoxamine, Fosamprenavir, Fostamatinib, Fostemsavir, Furazolidone, Gilteritinib, Glasdegib, Granisetron, Guanfacine, Haloperidol, Hydrocodone, Ibrexafungerp, Ibrutinib, Idelalisib, Imatinib, Imipramine, Indinavir, Infigratinib, Irinotecan, Isavuconazonium, Isocarboxazid, Isradipine, Istradefylline, Ivabradine, Ivacaftor, Ivosidenib, Ixazomib, Ketamine, Lapatinib, Larotrectinib, Lasmiditan, Lefamulin, Letermovir, Levomilnacipran, Levonorgestrel, Linezolid, Lonafarnib, Lorcaserin, Lorlatinib, Lumateperone, Lurasidone, Lurbinectedin, Maraviroc, Methylene Blue, Midostaurin, Milnacipran, Mirtazapine, Naldemedine, Naloxegol, Nefazodone, Nelfinavir, Neratinib, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Nimodipine, Nintedanib, Norethindrone, Norgestrel, Nortriptyline, Olaparib, Oliceridine, Ondansetron, Osilodrostat, Osimertinib, Oxycodone, Palbociclib, Palonosetron, Panobinostat, Paroxetine, Pemigatinib, Phenelzine, Pitolisant, Pralsetinib, Praziquantel, Pretomanid, Procarbazine, Propoxyphene, Protriptyline, Quetiapine, Ranolazine, Rasagiline, Relugolix, Ribociclib, Rilpivirine, Rimegepant, Ripretinib, Ritonavir, Rivaroxaban, Rolapitant, Safinamide, Saquinavir, Selegiline, Selpercatinib, Selumetinib, Sertraline, Sibutramine, Simeprevir, Siponimod, Sirolimus, Sofosbuvir, Sonidegib, Sotorasib, Stiripentol, Sunitinib, Suvorexant, Tacrolimus, Tapentadol, Tasimelteon, Tazemetostat, Telaprevir, Telithromycin, Temsirolimus, Tenofovir, Tepotinib, Ticagrelor, Tipranavir, Tivozanib, Tofacitinib, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranylcypromine, Trazodone, Trimipramine, Tryptophan, Tucatinib, Ubrogepant, Upadacitinib, Valbenazine, Vemurafenib, Venetoclax, Venlafaxine, Vilazodone, Voclosporin, Vorapaxar, Voriconazole, Vortioxetine, Voxelotor, Zanubrutinib

Related videos about St. John’s Wort


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