Kava, Kava Pepper, Kava Kava
- Origin Plant Based
- Source Itself
- Type Phytochemicals, Nootropic
Stress can be understood as a situation in which the individual is physically or mentally overloaded, which can cause pain, tension and physical injury, as well as emotional fatigue, tiredness, reduced productivity and attention. The substances that help control stress act on hormonal regulation (for example, cortisol), on the circadian cycle and promote physical and mental relaxation.
Anxiety is the body's natural response to stress. It's a feeling of fear or apprehension about what's to come. It can be triggered by a specific situation and not last long - which is very common and ok - or it can be a generalized disorder (which is considered a illness) that can bring harm to everyday life and also cause other conditions like depression.
Depression is a chronic and recurrent psychiatric condition that produces mood changes characterized by deep sadness, mood swings, loss of interest in activities, causing significant impairment in daily life.
Wellbeing is not just the absence of disease or illness. It's a complex combination of a person's physical, mental, emotional and social health factors. Wellbeing is strongly linked to happiness and life satisfaction. There are some lifestyle changes and natural products that can be very effective in that.
- Age Range Adults (20-59)
- Toxicity Toxic in high doses
- Side effects Liver Toxicity
- Warnings Hepatic Diseases
Why be Careful
The liver enzymes that break down kava also break down other drugs. Thus, kava can tie up these enzymes and prevent them from breaking down other drugs, causing them to build up and harm the liver. People without liver injuries and those who are not taking medications that affect the liver may be able to use kava safely in appropriate doses
- ^ a b c d e f St. John’s wort and Kava in treating major depressive disorder with comorbid anxiety: a randomised double-blind placebo-controlled pilot trial.
- ^ a b c d e Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder–an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients.
- ^ Kava-Kava administration reduces anxiety in perimenopausal women.
- ^ Evaluation of combining kava extract with hormone replacement therapy in the treatment of postmenopausal anxiety.
- ^ a b c d e f g h i j k Ulbricht C, et al. Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration. Expert Opin Drug Saf. (2005)
- ^ a b Singh YN. Kava: an overview. J Ethnopharmacol. (1992)
- ^ a b Mathews JD, et al. Effects of the heavy usage of kava on physical health: summary of a pilot survey in an aboriginal community. Med J Aust. (1988)
- ^ a b c Schelosky L, et al. Kava and dopamine antagonism. J Neurol Neurosurg Psychiatry. (1995)
- ^ a b Weiss J, et al. Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. Drug Metab Dispos. (2005)
- ^ a b He XG, Lin LZ, Lian LZ. Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract. Planta Med. (1997)
- ^ a b Clayton NP, et al. Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. Exp Toxicol Pathol. (2007)
- ^ a b c d e f g h i j k l Baum SS, Hill R, Rommelspacher H. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. (1998)
- ^ a b c Olsen LR, Grillo MP, Skonberg C. Constituents in kava extracts potentially involved in hepatotoxicity: a review. Chem Res Toxicol. (2011)
- ^ a b Whitton PA, et al. Kava lactones and the kava-kava controversy. Phytochemistry. (2003)
- ^ In Vitro Toxicity of Kava Alkaloid, Pipermethystine, in HepG2 Cells Compared to Kavalactones.
- ^ a b c Garrett KM, et al. Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. Psychopharmacology (Berl). (2003)
- ^ a b Keledjian J, et al. Uptake into mouse brain of four compounds present in the psychoactive beverage kava. J Pharm Sci. (1988)
- ^ a b c d Thompson R, Ruch W, Hasenöhrl RU. Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava). Hum Psychopharmacol. (2004)
- ^ a b c d Duffield AM, et al. Identification of some human urinary metabolites of the intoxicating beverage kava. J Chromatogr. (1989)
- ^ Rasmussen AK, et al. Metabolism of some kava pyrones in the rat. Xenobiotica. (1979)
- ^ Zou L, Harkey MR, Henderson GL. Synthesis, in vitro, reactivity, and identification of 6-phenyl-3-hexen-2-one in human urine after kava-kava (Piper methysticum) ingestion. Planta Med. (2005)
- ^ Mulholland PJ, Prendergast MA. Post-insult exposure to (+/-) kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus. Brain Res. (2002)
- ^ Davies LP, et al. Kava pyrones and resin: studies on GABAA, GABAB and benzodiazepine binding sites in rodent brain. Pharmacol Toxicol. (1992)
- ^ Jussofie A, Schmiz A, Hiemke C. Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain. Psychopharmacology (Berl). (1994)
- ^ Serdarevic N, Eckert GP, Müller WE. The effects of extracts from St. John’s Wort and Kava Kava on brain neurotransmitter levels in the mouse. Pharmacopsychiatry. (2001)
- ^ Dinh LD, et al. Interaction of various Piper methysticum cultivars with CNS receptors in vitro. Planta Med. (2001)
- ^ a b Backhauss C, Krieglstein J. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol. (1992)
- ^ Cropley M, et al. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions. Phytother Res. (2002)
- ^ Münte TF, et al. Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task. Neuropsychobiology. (1993)
- ^ a b Scherer J. Kava-kava extract in anxiety disorders: an outpatient observational study. Adv Ther. (1998)
- ^ a b Malsch U, Kieser M. Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines. Psychopharmacology (Berl). (2001)
- ^ a b Pittler MH, Ernst E. Kava extract for treating anxiety. Cochrane Database Syst Rev. (2003)
- ^ Connor KM, Payne V, Davidson JR. Kava in generalized anxiety disorder: three placebo-controlled trials. Int Clin Psychopharmacol. (2006)
- ^ Jacobs BP, et al. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore). (2005)
- ^ a b c Cairney S, et al. Saccade and cognitive function in chronic kava users. Neuropsychopharmacology. (2003)
- ^ a b c d Cairney S, et al. Saccade and cognitive impairment associated with kava intoxication. Hum Psychopharmacol. (2003)
- ^ a b c Spillane PK, Fisher DA, Currie BJ. Neurological manifestations of kava intoxication. Med J Aust. (1997)
- ^ a b c Robinson V, et al. Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. Int J Toxicol. (2009)
- ^ Herberg KW. Effect of Kava-Special Extract WS 1490 combined with ethyl alcohol on safety-relevant performance parameters. Blutalkohol. (1993)
- ^ Foo H, Lemon J. Acute effects of kava, alone or in combination with alcohol, on subjective measures of impairment and intoxication and on cognitive performance. Drug Alcohol Rev. (1997)
- ^ a b c Jamieson DD, Duffield PH. Positive interaction of ethanol and kava resin in mice. Clin Exp Pharmacol Physiol. (1990)
- ^ Mathews JM, et al. Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro. Drug Metab Dispos. (2005)
- ^ Schulze J, Raasch W, Siegers CP. Toxicity of kava pyrones, drug safety and precautions–a case study. Phytomedicine. (2003)
- ^ Sarris J, et al. The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology (Berl). (2009)
- ^ a b c Clouatre DL. Kava kava: examining new reports of toxicity. Toxicol Lett. (2004)
- ^ Russmann S, Lauterburg BH, Helbling A. Kava hepatotoxicity. Ann Intern Med. (2001)
- ^ Humberston CL, Akhtar J, Krenzelok EP. Acute hepatitis induced by kava kava. J Toxicol Clin Toxicol. (2003)
- ^ Gow PJ, et al. Fatal fulminant hepatic failure induced by a natural therapy containing kava. Med J Aust. (2003)
- ^ Sorrentino L, Capasso A, Schmidt M. Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats. Phytomedicine. (2006)
- ^ Singh YN, Devkota AK. Aqueous kava extracts do not affect liver function tests in rats. Planta Med. (2003)
- ^ Clough AR, et al. Health effects of kava use in an eastern Arnhem Land Aboriginal community. Intern Med J. (2003)
- ^ a b Guro-Razuman S, et al. Dermatomyositis-like illness following kava-kava ingestion. J Clin Rheumatol. (1999)
- ^ Norton SA, Ruze P. Kava dermopathy. J Am Acad Dermatol. (1994)
- ^ Ruze P. Kava-induced dermopathy: a niacin deficiency. Lancet. (1990)
- ^ Ernst E. Adverse effects of herbal drugs in dermatology. Br J Dermatol. (2000)
- ^ a b c Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos. (2002)
- ^ Zou L, et al. Effects of kava (Kava-kava, ‘Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. Phytomedicine. (2004)
- ^ Unger M, et al. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Med. (2002)
- ^ Gurley BJ, et al. Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. Clin Pharmacol Ther. (2008)
- ^ Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans.
- ^ Pittler MH, Ernst E. Efficacy of kava extract for treating anxiety: systematic review and meta-analysis. J Clin Psychopharmacol. (2000)
- ^ Hsu SY, et al. Toxicologic studies of dihydro-5,6-dehydrokawain and 5,6-dehydrokawain. Planta Med. (1994)
- Volz HP, Kieser M. Kava-kava extract WS 1490 versus placebo in anxiety disorders–a randomized placebo-controlled 25-week outpatient trial. Pharmacopsychiatry. (1997)
- Lehrl S. Clinical efficacy of kava extract WS 1490 in sleep disturbances associated with anxiety disorders. Results of a multicenter, randomized, placebo-controlled, double-blind clinical trial. J Affect Disord. (2004)
- Geier FP, Konstantinowicz T. Kava treatment in patients with anxiety. Phytother Res. (2004)
- Gastpar M, Klimm HD. Treatment of anxiety, tension and restlessness states with Kava special extract WS 1490 in general practice: a randomized placebo-controlled double-blind multicenter trial. Phytomedicine. (2003)
- Connor KM, Davidson JR. A placebo-controlled study of Kava kava in generalized anxiety disorder. Int Clin Psychopharmacol. (2002)
- Wheatley D. Kava and valerian in the treatment of stress-induced insomnia. Phytother Res. (2001)