Iron, Iron

Iron is an essential mineral for the body, as it participates in the formation of blood cells and helps in the transport of oxygen. It is also important for DNA synthesis and energy metabolism. The lack of iron can harm the body in several ways, related to immunological problems, productivity and mental performance.

  • Origin: Plant Based, Animal Product
  • Source: Eggs, Meat, Fish, Beans, Chickpea, Leafy Greens, Beetroot, Peanuts, Walnuts, Oatmeal, Spirulina Algae, Chlorella Algae, Seaweeds, Cocoa
  • Type: Mineral
  • Age Range: Adults, Seniors
  • Toxicity: May be toxic in high doses
  • Outcomes: Cognitive Function and Brain Health, Cognitive Enhancer

What are Iron benefits?

Iron is an essential mineral for the development and functioning of the human body and is a critical component of hemoglobin since iron allows blood to transport oxygen between tissues. Remember that iron is commonly found in plants (mainly grains and legumes), however, it is less bioavailable than the iron found in meat (in heme form). Many scholars consider iron to be a double-edged sword in the world of nutrients. While on the one hand, many people have insufficient levels, leading to anemia; on the other hand, iron overload can be toxic to a wide variety of cells. Lack of iron tends to produce fatigue, depression, impaired cognitive function, restless leg syndrome, and other adverse effects. Correcting an iron deficiency tends to improve symptoms. Thus, iron supplementation should only be considered if the body is deficient in iron. For people who already have enough iron, taking an iron supplement has no proven benefit; on the contrary, it can lead to an iron overdose.

Table of relations

Consistent effects
Strength of effects
Scientific articles

Cognitive Function and Brain Health Iron and Cognitive Function and Brain Health

Cognitive functions are brain skills divided into: memory, perception, language, executive functions, attention and praxis (ability to perform complex movements). These functions depend on healthy synapses and neurons, which require good overall brain functioning. Supplements can affect cognitive performance directly or indirectly. Direct effects can alter or participate in neurotransmissions and influence the brain's energy metabolism. The indirect effects include hormonal changes that affect the brain, and improvements in cognitive disorders such as anxiety, depression and insomnia.
  • Cognitive Enhancer

    Cognition encompasses many factors, such as thinking, language, perception, and memory. When talking about cognitive improvement, we define age-related decline in cognitive health as something common, however, knowing which habits negatively influence it and how to prevent any loss in these areas is important. In addition to age, factors such as injury, family history, or bad habits can influence the decline to some degree of the sectors involved. Several studies associate nutrition with the improvement of brain and cognitive function; the ingestion of nutraceuticals for this purpose optimizes this process and guarantees results with scientific proof.

Table of negative interactions

Benazepril, Captopril, Dimercaprol, Enalapril, Enalaprilat, Fosinopril, Lisinopril, Moexipril, Perindopril, Quinapril, Ramipril, Trandolapri

Related videos about Iron


  1. a b c Beard JL, Dawson H, Piñero DJ. Iron metabolism: a comprehensive reviewNutr Rev. (1996)
  2. ^ Sánchez M et al.. Iron chemistry at the service of lifeIUBMB Life. (2017)
  3. ^ Gozzelino R, Arosio P. Iron Homeostasis in Health and DiseaseInt J Mol Sci. (2016)
  4. ^ Bandyopadhyay S, Chandramouli K, Johnson MK. Iron-sulfur cluster biosynthesisBiochem Soc Trans. (2008)
  5. ^ Lill R, Mühlenhoff U. Iron-sulfur protein biogenesis in eukaryotes: components and mechanismsAnnu Rev Cell Dev Biol. (2006)
  6. ^ Ayala-Castro C, Saini A, Outten FW. Fe-S cluster assembly pathways in bacteriaMicrobiol Mol Biol Rev. (2008)
  7. ^ Balk J, Lobréaux S. Biogenesis of iron-sulfur proteins in plantsTrends Plant Sci. (2005)
  8. ^ Muthuswamy S, Agarwal S. Friedreich Ataxia: From the Eye of a Molecular BiologistNeurologist. (2005)
  9. ^ Bruni F, Lightowlers RN, Chrzanowska-Lightowlers ZM. Human mitochondrial nucleasesFEBS J. (2016)
  10. ^ Eid R, Arab NT, Greenwood MT. Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigmsBiochim Biophys Acta. (2017)
  11. ^ Koskenkorva-Frank TS, et al. The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stressFree Radic Biol Med. (2013)
  12. a b Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc.
  13. ^ The Canadian Paediatric Society. Meeting the iron needs of infants and young children: an update. Nutrition Committee, Canadian Paediatric SocietyCMAJ. (1991)
  14. ^ The American Academy of Pediatrics. Iron Fortification of Infant Formulas.
  15. ^ Milman N, Kirchhoff M. Influence of blood donation on iron stores assessed by serum ferritin and haemoglobin in a population survey of 1433 Danish malesEur J Haematol. (1991)
  16. ^ Walter T et al.. Iron deficiency anemia: adverse effects on infant psychomotor developmentPediatrics. (1989)
  17. ^ Lozoff B et al.. Long-lasting neural and behavioral effects of iron deficiency in infancyNutr Rev. (2006)
  18. ^ Camaschella, C. Iron-Deficiency AnemiaN Engl J Med. (2015)
  19. ^ Tekin D, et al. Possible effects of antioxidant status on increased platelet aggregation in childhood iron-deficiency anemiaPediatr Int. (2001)
  20. ^ Isler M, et al. Superoxide dismutase and glutathione peroxidase in erythrocytes of patients with iron deficiency anemia: effects of different treatment modalitiesCroat Med J. (2002)
  21. ^ Kurtoglu E, et al. Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemiaBiol Trace Elem Res. (2003)
  22. ^ Garry PJ, et al. A prospective study of blood donations in healthy elderly personsTransfusion. (1991)
  23. ^ Garry PJ, Koehler KM, Simon TL. Iron stores and iron absorption: effects of repeated blood donationsAm J Clin Nutr. (1995)
  24. ^ Baart AM, et al. High prevalence of subclinical iron deficiency in whole blood donors not deferred for low hemoglobinTransfusion. (2013)
  25. ^ Cable RG, et al. Iron deficiency in blood donors: the REDS-II Donor Iron Status Evaluation (RISE) studyTransfusion. (2012)
  26. ^ Cable RG, et al. Iron deficiency in blood donors: analysis of enrollment data from the REDS-II Donor Iron Status Evaluation (RISE) studyTransfusion. (2011)
  27. ^ Shander A, et al. Prevalence and outcomes of anemia in surgery: a systematic review of the literatureAm J Med. (2004)
  28. ^ Kochhar R, et al. Clinical presentation of celiac disease among pediatric compared to adolescent and adult patientsIndian J Gastroenterol. (2012)
  29. a b Berry N, et al. Anemia in celiac disease is multifactorial in etiology: A prospective study from IndiaJGH Open. (2018)
  30. ^ Bottaro G, et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive casesAm J Gastroenterol. (1999)
  31. ^ Murray JA, et al. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001Clin Gastroenterol Hepatol. (2003)
  32. ^ West J, et al. Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based studyAm J Gastroenterol. (2014)
  33. ^ Harper JW, et al. Anemia in celiac disease is multifactorial in etiologyAm J Hematol. (2007)
  34. ^ Vici G, et al. Gluten free diet and nutrient deficiencies: A reviewClin Nutr. (2016)
  35. ^ Enani G, et al. The incidence of iron deficiency anemia post-Roux-en-Y gastric bypass and sleeve gastrectomy: a systematic reviewSurg Endosc. (2019)
  36. ^ Ganz T. Molecular pathogenesis of anemia of chronic diseasePediatr Blood Cancer. (2006)
  37. ^ D’Angelo G. Role of hepcidin in the pathophysiology and diagnosis of anemiaBlood Res. (2013)
  38. ^ Filmann N, et al. Prevalence of anemia in inflammatory bowel diseases in european countries: a systematic review and individual patient data meta-analysisInflamm Bowel Dis. (2014)
  39. ^ Cooke AG, et al. Iron Deficiency Anemia in Adolescents Who Present with Heavy Menstrual BleedingJ Pediatr Adolesc Gynecol. (2017)
  40. ^ Barr F, et al. Reducing iron deficiency anaemia due to heavy menstrual blood loss in Nigerian rural adolescentsPublic Health Nutr. (1998)
  41. ^ Hudak L, et al. An updated systematic review and meta-analysis on the association between Helicobacter pylori infection and iron deficiency anemiaHelicobacter. (2017)
  42. ^ Hou B, et al. Association of active Helicobacter pylori infection and anemia in elderly malesBMC Infect Dis. (2019)
  43. ^ Zhang ZW, et al. The relation between gastric vitamin C concentrations, mucosal histology, and CagA seropositivity in the human stomachGut. (1998)
  44. ^ Calam J. Helicobacter pylori modulation of gastric acidYale J Biol Med. (1999)
  45. ^ Park JH, et al. Correlation between Helicobacter pylori infection and vitamin C levels in whole blood, plasma, and gastric juice, and the pH of gastric juice in Korean childrenJ Pediatr Gastroenterol Nutr. (2003)
  46. ^ Rood JC, et al. Helicobacter pylori-associated gastritis and the ascorbic acid concentration in gastric juiceNutr Cancer. (1994)
  47. ^ Sobala GM, et al. Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrationsGut. (1993)
  48. ^ McMahon LP. Iron deficiency in pregnancyObstet Med. (2010)
  49. ^ Fischer JG, et al. Moderate iron overload enhances lipid peroxidation in livers of rats, but does not affect NF-kappaB activation induced by the peroxisome proliferator, Wy-14,643J Nutr. (2002)
  50. ^ Pietrangelo A. Mechanisms of iron hepatotoxicityJ Hepatol. (2016)
  51. ^ Day SM, et al. Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosisCirculation. (2003)
  52. ^ Horwitz LD, Rosenthal EA. Iron-mediated cardiovascular injuryVasc Med. (1999)
  53. ^ Glei M, et al. Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19AMutat Res. (2002)
  54. ^ Winterbourn CC. Toxicity of iron and hydrogen peroxide: the Fenton reactionToxicol Lett. (1995)
  55. ^ Kehrer JP. The Haber-Weiss reaction and mechanisms of toxicityToxicology. (2000)
  56. ^ Crichton RR, et al. Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cellsJ Inorg Biochem. (2002)
  57. ^ Brissot P, et al. Non-transferrin bound iron: a key role in iron overload and iron toxicityBiochim Biophys Acta. (2012)
  58. ^ Aljwaid H, et al. Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetesJ Diabetes Complications. (2015)
  59. ^ Lee DH, et al. Common presence of non-transferrin-bound iron among patients with type 2 diabetesDiabetes Care. (2006)
  60. ^ Imam MU, et al. Antioxidants Mediate Both Iron Homeostasis and Oxidative StressNutrients. (2017)
  61. ^ Ma Q, et al. Bioactive dietary polyphenols inhibit heme iron absorption in a dose-dependent manner in human intestinal Caco-2 cellsJ Food Sci. (2011)
  62. ^ Shin JH, et al. Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2Int J Mol Med. (2016)
  63. a b c Jiao Y, et al. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelatorBlood. (2009)
  64. ^ Zhong W, et al. Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-κB related signalingBiomed Pharmacother. (2016)
  65. ^ Tang Y, et al. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathwayJ Nutr Biochem. (2014)
  66. ^ Moayedi Esfahani BA, Reisi N, Mirmoghtadaei M. Evaluating the safety and efficacy of silymarin in β-thalassemia patients: a reviewHemoglobin. (2015)
  67. ^ Morgan EH, Oates PS. Mechanisms and regulation of intestinal iron absorptionBlood Cells Mol Dis. (2002)
  68. a b c Sharp P, Srai SK. Molecular mechanisms involved in intestinal iron absorptionWorld J Gastroenterol. (2007)
  69. ^ Le Blanc S, Garrick MD, Arredondo M. Heme carrier protein 1 transports heme and is involved in heme-Fe metabolismAm J Physiol Cell Physiol. (2012)
  70. ^ Cabantchik ZI, et al. Intracellular and extracellular labile iron poolsAdv Exp Med Biol. (2002)
  71. ^ Carpenter CE, Mahoney AW. Contributions of heme and nonheme iron to human nutritionCrit Rev Food Sci Nutr. (1992)
  72. ^ Ganz T, Nemeth E. Hepcidin and iron homeostasisBiochim Biophys Acta. (2012)
  73. a b Stoffel NU, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trialsLancet Haematol. (2017)
  74. ^ Stoffel NU, et al. Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic womenHaematologica. (2019)
  75. ^ Moretti D, et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young womenBlood. (2015)
  76. ^ Adaji JA, et al. Daily versus twice daily dose of ferrous sulphate supplementation in pregnant women: A randomized clinical trialNiger J Clin Pract. (2019)
  77. ^ Ali MK, et al. A randomized clinical trial of the efficacy of single versus double-daily dose of oral iron for prevention of iron deficiency anemia in women with twin gestationsJ Matern Fetal Neonatal Med. (2017)
  78. a b Fernández-Gaxiola AC, De-Regil LM. Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating womenCochrane Database Syst Rev. (2019)
  79. ^ Lynch SR, et al. The effect of dietary proteins on iron bioavailability in manAdv Exp Med Biol. (1989)
  80. ^ Reddy MB, Hurrell RF, Cook JD. Meat consumption in a varied diet marginally influences nonheme iron absorption in normal individualsJ Nutr. (2006)
  81. ^ Baech SB, et al. Nonheme-iron absorption from a phytate-rich meal is increased by the addition of small amounts of pork meatAm J Clin Nutr. (2003)
  82. ^ Bach Kristensen M, et al. Pork meat increases iron absorption from a 5-day fully controlled diet when compared to a vegetarian diet with similar vitamin C and phytic acid contentBr J Nutr. (2005)
  83. ^ Santiago Navas-Carretero, et al. Oily fish increases iron bioavailability of a phytate rich meal in young iron deficient womenJ Am Coll Nutr. (2008)
  84. ^ Manoppo J, et al. The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemiaKorean J Pediatr. (2019)
  85. ^ Hoppe M, Önning G, Hulthén L. Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females-Double isotope sequential single-blind studies in menstruating womenPLoS One. (2017)
  86. ^ Hoppe M, et al. Probiotic strain Lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive ageBr J Nutr. (2015)
  87. ^ Rosen GM, et al. Use of a Probiotic to Enhance Iron Absorption in a Randomized Trial of Pediatric Patients Presenting with Iron DeficiencyJ Pediatr. (2019)
  88. ^ Simeoni M, et al. An open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD)Eur J Nutr. (2019)
  89. ^ Sazawal S, et al. Effects of Bifidobacterium lactis HN019 and prebiotic oligosaccharide added to milk on iron status, anemia, and growth among children 1 to 4 years oldJ Pediatr Gastroenterol Nutr. (2010)
  90. ^ Mohammad MA, et al. Plasma cobalamin and folate and their metabolic markers methylmalonic acid and total homocysteine among Egyptian children before and after nutritional supplementation with the probiotic bacteria Lactobacillus acidophilus in yoghurt matrixInt J Food Sci Nutr. (2006)
  91. ^ Atanassova BD, Tzatchev KN. Ascorbic acid–important for iron metabolismFolia Med (Plovdiv). (2008)
  92. ^ Hallberg L, Brune M, Rossander L. Effect of ascorbic acid on iron absorption from different types of meals. Studies with ascorbic-acid-rich foods and synthetic ascorbic acid given in different amounts with different mealsHum Nutr Appl Nutr. (1986)
  93. ^ Lane DJ, Lawen A. Non-transferrin iron reduction and uptake are regulated by transmembrane ascorbate cycling in K562 cellsJ Biol Chem. (2008)
  94. ^ May JM, Qu ZC, Mendiratta S. Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cellsBiochem Pharmacol. (1999)
  95. ^ Lane DJ et al.. Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanismBiochim Biophys Acta. (2013)
  96. ^ Clark NG, Sheard NF, Kelleher JF. Treatment of iron-deficiency anemia complicated by scurvy and folic acid deficiencyNutr Rev. (1992)
  97. ^ Cox EV. The anemia of scurvyVitam Horm. (1968)
  98. ^ da Cunha MSB, Campos Hankins NA, Arruda SF. Effect of vitamin A supplementation on iron status in humans: A systematic review and meta-analysisCrit Rev Food Sci Nutr. (2019)
  99. ^ Cañete A, et al. Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult HematopoiesisNutrients. (2017)
  100. ^ García-Casal MN, et al. Vitamin A and beta-carotene can improve nonheme iron absorption from rice, wheat and corn by humansJ Nutr. (1998)
  101. ^ Masoud MS, et al. Vitamin D Supplementation Modestly Reduces Serum Iron Indices of Healthy Arab AdolescentsNutrients. (2018)
  102. ^ Braithwaite VS, et al. The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United KingdomNutrients. (2019)
  103. ^ Madar AA, et al. Effect of vitamin D3 supplementation on iron status: a randomized, double-blind, placebo-controlled trial among ethnic minorities living in NorwayNutr J. (2016)
  104. ^ Smith EM, et al. High-dose vitamin D3 reduces circulating hepcidin concentrations: A pilot, randomized, double-blind, placebo-controlled trial in healthy adultsClin Nutr. (2017)
  105. ^ Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorptionAm J Clin Nutr. (1991)
  106. ^ Seligman PA, et al. Measurements of iron absorption from prenatal multivitamin–mineral supplementsObstet Gynecol. (1983)
  107. ^ Dawson-Hughes B, Seligson FH, Hughes VA. Effects of calcium carbonate and hydroxyapatite on zinc and iron retention in postmenopausal womenAm J Clin Nutr. (1986)
  108. ^ Candia V, et al. Effect of various calcium salts on non-heme iron bioavailability in fasted women of childbearing ageJ Trace Elem Med Biol. (2018)
  109. ^ Gaitán D, et al. Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant womenJ Nutr. (2011)
  110. ^ Hallberg L, et al. Calcium: effect of different amounts on nonheme- and heme-iron absorption in humansAm J Clin Nutr. (1991)
  111. a b c Hurrell RF1, Reddy M, Cook JD. Inhibition of non-haem iron absorption in man by polyphenolic-containing beveragesBr J Nutr. (1999)
  112. ^ Kono Y1, et al. Iron chelation by chlorogenic acid as a natural antioxidantBiosci Biotechnol Biochem. (1998)
  113. a b c Samman S1, et al. Green tea or rosemary extract added to foods reduces nonheme-iron absorptionAm J Clin Nutr. (2001)
  114. ^ O’Coinceanainn M1, et al. Reaction of iron(III) with theaflavin: complexation and oxidative productsJ Inorg Biochem. (2004)
  115. a b Tuntipopipat S1, et al. Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite mealJ Nutr. (2006)
  116. ^ Fernandez R, Phillips SF. Components of fiber bind iron in vitroAm J Clin Nutr. (1982)
  117. ^ Trinidad TP1, Wolever TM, Thompson LU. Availability of calcium for absorption in the small intestine and colon from diets containing available and unavailable carbohydrates: an in vitro assessmentInt J Food Sci Nutr. (1996)
  118. ^ Rossander L. Effect of dietary fiber on iron absorption in manScand J Gastroenterol Suppl. (1987)
  119. ^ Bell LP1, et al. Cholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemiaAm J Clin Nutr. (1990)
  120. ^ Dennison BA1, Levine DM. Randomized, double-blind, placebo-controlled, two-period crossover clinical trial of psyllium fiber in children with hypercholesterolemiaJ Pediatr. (1993)
  121. ^ Anderson JW1, et al. Cholesterol-lowering effects of psyllium hydrophilic mucilloid for hypercholesterolemic menArch Intern Med. (1988)
  122. ^ Sajadi Hezaveh Z, et al. The effect of quercetin on iron overload and inflammation in β-thalassemia major patients: A double-blind randomized clinical trialComplement Ther Med. (2019)
  123. ^ Leopoldini M, et al. Iron chelation by the powerful antioxidant flavonoid quercetinJ Agric Food Chem. (2006)
  124. ^ Liuzzi JP, et al. Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cellsProc Natl Acad Sci U S A. (2006)
  125. ^ Espinoza A, et al. Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNABiol Trace Elem Res. (2012)
  126. ^ Olivares M, et al. Acute inhibition of iron bioavailability by zinc: studies in humansBiometals. (2012)
  127. ^ O’Brien KO, et al. Influence of prenatal iron and zinc supplements on supplemental iron absorption, red blood cell iron incorporation, and iron status in pregnant Peruvian womenAm J Clin Nutr. (1999)
  128. ^ Nguyen P, et al. Effect of zinc on efficacy of iron supplementation in improving iron and zinc status in womenJ Nutr Metab. (2012)
  129. ^ Donangelo CM, et al. Supplemental zinc lowers measures of iron status in young women with low iron reservesJ Nutr. (2002)
  130. ^ de Brito NJ, et al. Oral zinc supplementation decreases the serum iron concentration in healthy schoolchildren: a pilot studyNutrients. (2014)
  131. ^ Lopez de Romaña D, et al. Supplementation with zinc between meals has no effect on subsequent iron absorption or on iron status of Chilean womenNutrition. (2008)
  132. ^ Urrechaga E. Influence of iron deficiency on Hb A1c levels in type 2 diabetic patientsDiabetes Metab Syndr. (2018)
  133. ^ Madhu SV, et al. Effect of iron deficiency anemia and iron supplementation on HbA1c levels – Implications for diagnosis of prediabetes and diabetes mellitus in Asian IndiansClin Chim Acta. (2017)
  134. ^ Christy AL, et al. Influence of iron deficiency anemia on hemoglobin A1c levels in diabetic individuals with controlled plasma glucose levelsIran Biomed J. (2014)
  135. ^ Naslı-Esfahani E, et al. Effect of treatment of iron deficiency anemia onhemoglobin A1c in type 2 diabetic patientsTurk J Med Sci. (2017)
  136. ^ Renz PB, Hernandez MK, Camargo JL. Effect of iron supplementation on HbA1c levels in pregnant women with and without anaemiaClin Chim Acta. (2018)
  137. ^ Gram-Hansen P, et al. Glycosylated haemoglobin (HbA1c) in iron- and vitamin B12 deficiencyJ Intern Med. (1990)
  138. ^ Coban E, Ozdogan M, Timuragaoglu A. Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patientsActa Haematol. (2004)
  139. ^ El-Agouza I, Abu Shahla A, Sirdah M. The effect of iron deficiency anaemia on the levels of haemoglobin subtypes: possible consequences for clinical diagnosisClin Lab Haematol. (2002)
  140. ^ Li Z. Dietary zinc and iron intake and risk of depression: A meta-analysisPsychiatry Res. (2017)
  141. ^ Vafa M, et al. Comparing the effectiveness of vitamin D plus iron vs vitamin D on depression scores in anemic females: Randomized triple-masked trialMed J Islam Repub Iran. (2019)
  142. ^ Wassef A, Nguyen QD, St-André M. Anaemia and depletion of iron stores as risk factors for postpartum depression: a literature reviewJ Psychosom Obstet Gynaecol. (2019)
  143. ^ Beard JL, et al. Maternal iron deficiency anemia affects postpartum emotions and cognitionJ Nutr. (2005)
  144. ^ Sheikh M, et al. The efficacy of early iron supplementation on postpartum depression, a randomized double-blind placebo-controlled trialEur J Nutr. (2017)
  145. ^ Holm C, et al. Single-dose intravenous iron infusion or oral iron for treatment of fatigue after postpartum haemorrhage: a randomized controlled trialVox Sang. (2017)
  146. ^ Perelló MF, et al. Intravenous ferrous sucrose versus placebo in addition to oral iron therapy for the treatment of severe postpartum anaemia: a randomised controlled trialBJOG. (2014)
  147. ^ Avni T, et al. Iron supplementation for restless legs syndrome – A systematic review and meta-analysisEur J Intern Med. (2019)
  148. ^ Chung J, Chen C, Paw BH. Heme metabolism and erythropoiesisCurr Opin Hematol. (2012)
  149. ^ Bonaventura C et al.. Molecular controls of the oxygenation and redox reactions of hemoglobinAntioxid Redox Signal. (2013)
  150. ^ Kosman DJ. Redox cycling in iron uptake, efflux, and traffickingJ Biol Chem. (2010)
  151. ^ Bender MA, Douthitt Seibel G. Sickle Cell DiseaseGene Reviews. (2003)
  152. ^ Chan CQ, Low LL, Lee KH. Oral Vitamin B12 Replacement for the Treatment of Pernicious AnemiaFront Med (Lausanne). (2016)
  153. a b Fernández-Gaxiola AC, De-Regil LM. Intermittent iron supplementation for reducing anaemia and its associated impairments in menstruating womenCochrane Database Syst Rev. (2011)
  154. ^ Johnson-Wimbley TD, Graham DY. Diagnosis and management of iron deficiency anemia in the 21st centuryTherap Adv Gastroenterol. (2011)
  155. ^ Clark SF. Iron deficiency anemia: diagnosis and managementCurr Opin Gastroenterol. (2009)
  156. ^ Bairwa M et al.. Directly observed iron supplementation for control of iron deficiency anemiaIndian J Public Health. (2017)
  157. ^ Italiani P, Boraschi D. From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional DifferentiationFront Immunol. (2014)
  158. ^ Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and diseaseNature. (2013)
  159. ^ Alam MZ, Devalaraja S, Haldar M. The Heme Connection: Linking Erythrocytes and Macrophage BiologyFront Immunol. (2017)
  160. ^ Kumar S, Bandyopadhyay U. Free heme toxicity and its detoxification systems in humanToxicol Lett. (2005)
  161. ^ Bratosin D et al.. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A reviewBiochimie. (1998)
  162. ^ Haas JD, Brownlie T 4th. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationshipJ Nutr. (2001)
  163. ^ Houston BL, et al. Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trialsBMJ Open. (2018)
  164. ^ Pompano LM, Haas JD. Increasing Iron Status through Dietary Supplementation in Iron-Depleted, Sedentary Women Increases Endurance Performance at Both Near-Maximal and Submaximal Exercise IntensitiesJ Nutr. (2019)
  165. Brownlie T 4th, et al. Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained womenAm J Clin Nutr. (2002)
  166. Brutsaert TD, et al. Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic womenAm J Clin Nutr. (2003)
  167. Favrat B, et al. Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women–PREFER a randomized, placebo-controlled studyPLoS One. (2014)
  168. Krayenbuehl PA, et al. Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentrationBlood. (2011)
  169. Verdon F, et al. Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trialBMJ. (2003)
  170. Vaucher P, et al. Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trialCMAJ. (2012)
  171. Waldvogel S, et al. Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trialBMC Med. (2012)
  172. McClung JP, et al. Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: effects on iron status, physical performance, and moodAm J Clin Nutr. (2009)
  173. Woods A, et al. Four weeks of IV iron supplementation reduces perceived fatigue and mood disturbance in distance runnersPLoS One. (2014)
  174. McLean E, et al. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005Public Health Nutr. (2009)
  175. Clark SF. Iron deficiency anemiaNutr Clin Pract. (2008)
  176. Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injuryBiomed Pharmacother. (2001)
  177. McCord JM. Iron, free radicals, and oxidative injurySemin Hematol. (1998)
  178. Kell DB. Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examplesArch Toxicol. (2010)
  179. Fang X, et al. Dietary intake of heme iron and risk of cardiovascular disease: a dose-response meta-analysis of prospective cohort studiesNutr Metab Cardiovasc Dis. (2015)
  180. Qiao L, Feng Y. Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studiesCancer Causes Control. (2013)
  181. Morris CC. Pediatric iron poisonings in the United StatesSouth Med J. (2000)
  182. Dean BS, Krenzelok EP. Multiple vitamins and vitamins with iron: accidental poisoning in childrenVet Hum Toxicol. (1988)
  183. Brune M, Rossander L, Hallberg L. Iron absorption and phenolic compounds: importance of different phenolic structuresEur J Clin Nutr. (1989)
  184. Skikne B, et al. Iron and blood donationClin Haematol. (1984)
  185. Sim Y Ong, et al. Reduction of Body Iron in HFE-related Haemochromatosis and Moderate Iron Overload (Mi-Iron): A Multicentre, Participant-Blinded, Randomised Controlled TrialLancet Haematol. (2017)
  186. Fabrice Lainé, et al. Metabolic and Hepatic Effects of Bloodletting in Dysmetabolic Iron Overload Syndrome: A Randomized Controlled Study in 274 PatientsHepatology. (2017)
  187. Elahe Mohammadi, et al. An Investigation of the Effects of Curcumin on Iron Overload, Hepcidin Level, and Liver Function in β-Thalassemia Major Patients: A Double-Blind Randomized Controlled Clinical TrialPhytother Res. (2018)
  188. Brittin HC, Nossaman CE. Iron content of food cooked in iron utensilsJ Am Diet Assoc. (1986)
  189. Geerligs PD, Brabin BJ, Omari AA. Food prepared in iron cooking pots as an intervention for reducing iron deficiency anaemia in developing countries: a systematic reviewJ Hum Nutr Diet. (2003)
  190. Adish AA, et al. Effect of consumption of food cooked in iron pots on iron status and growth of young children: a randomised trialLancet. (1999)
  191. Thyssen JP, Menné T. Metal allergy–a review on exposures, penetration, genetics, prevalence, and clinical implicationsChem Res Toxicol. (2010)
  192. Kuligowski J, Halperin KM. Stainless steel cookware as a significant source of nickel, chromium, and ironArch Environ Contam Toxicol. (1992)
  193. Chiang TA, Wu PF, Ko YC. Identification of carcinogens in cooking oil fumesEnviron Res. (1999)
  194. Skog K, et al. Acrylamide in home-prepared roasted potatoesMol Nutr Food Res. (2008)
  195. Sugimura T, et al. Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fishCancer Sci. (2004)
  196. Konings EJ, et al. Acrylamide in cereal and cereal products: a review on progress in level reductionFood Addit Contam. (2007)
  197. Woodhall S, Stamford M. PTFE toxicity in birdsVet Rec. (2004)
  198. Hamaya R, et al. Polytetrafluoroethylene fume-induced pulmonary edema: a case report and review of the literatureJ Med Case Rep. (2015)