Decarboxylated arginine, Agmatine

Agmatine is a compound synthesized from the amino acid arginine by the enzyme arginine decarboxylase.The supplementation occurs in agmatine sulfate form. Agmatine sulfate is absorbed in the gastrointestinal tract and is then quickly distributed throughout the body, including the brain. So on, agmatine sulfate can be used in a wide range of conditions, from the treatment of diabetes, neuropathies, neurodegenerative diseases and behavioral and cognitive disorders, even to improve sports performance, as it has a vasodilator effect, allowing an adequate supply of nutrients to the muscle tissue and favoring hypertrophy.

  • Origin: Animal Product, Plant Based, Synthetic
  • Source: Synthetic, Wine, Beer, Fish, Meat, Sake, Coffee
  • Type: Amino Acids
  • Age Range: Adults
  • Toxicity: There is no evidence of toxicity until now
  • Outcomes: Energy and Mood, Depression

What are Agmatine benefits?

Agmatine is a metabolite of the amino acid arginine. Discovered in 1910 by the Nobel Prize winner Albrecht Kossel, it is absorbed from the intestine and distributed throughout the body, including the nervous system. In studies done with agmatine, a reduction in pain has been proven. The result indicated a drop in pain even after supplementation. In other research, depression fell sharply when volunteers were given 2-3 g of agmatine. As its major benefit is mood, its use has become known among people with depression and/or anxiety. Through our 3 steps you can check the action of this nutraceutical in your health in a personalized way!

Table of relations

Energy and Mood Agmatine and Energy and Mood

Energy and mood are associated with several external and internal factors. Hormone release, brain chemical balance, nutrient metabolism, and several other elements alter the way the body and mind respond to daily activities. The compounds that benefit energy and mood are the ones that help in the balance of all these factors.
  • Depression

    Depression is a chronic and recurrent psychiatric condition that produces mood changes characterized by deep sadness, mood swings, loss of interest in activities, causing significant impairment in daily life.

Table of negative interactions

Drugs
Amiloride, Spironolactone, Triamterene, Alemtuzumab, Amifampridine, Atropine, Belladonna, Benztropine, Biperiden, Cladribine, Clidinium, Clozapine, Darifenacin, Deferiprone, Dicyclomine, Disopyramide, Donepezil, Flavoxate, Galantamine, Ganciclovir, Glycopyrrolate, Hyoscyamine, Mepenzolate, Methscopolamine, Ocrelizumab, Omacetaxine, Oxybutynin, Physostigmine, Procainamide, Procyclidine, Propantheline, Quinidine, Radium 223 Dichloride, Rivastigmine, Scopolamine, Solifenacin, Tacrine, Tolterodine, Trihexyphenidyl, Trospium, Ustekinumab, Valganciclovir

Related videos about Agmatine

References

  1. ^ Naila A, et al. Control of biogenic amines in food–existing and emerging approachesJ Food Sci. (2010)
  2. a b c Molderings GJ, Haenisch B. Agmatine (decarboxylated L-arginine): physiological role and therapeutic potentialPharmacol Ther. (2012)
  3. a b Holt A, Baker GB. Metabolism of agmatine (clonidine-displacing substance) by diamine oxidase and the possible implications for studies of imidazoline receptorsProg Brain Res. (1995)
  4. ^ Galgano F, et al. Focused review: agmatine in fermented foodsFront Microbiol. (2012)
  5. ^ Authentication of Italian red wines on the basis of the polyphenols and biogenic amines.
  6. ^ HPLC determination of agmatine and other amines in wine.
  7. ^ De Borba BM, Rohrer JS. Determination of biogenic amines in alcoholic beverages by ion chromatography with suppressed conductivity detection and integrated pulsed amperometric detectionJ Chromatogr A. (2007)
  8. ^ The biogenic amine content of beer; the effect of barley, malting and brewing on amine concentration.
  9. ^ Kvasnicka F, Voldrich M. Determination of biogenic amines by capillary zone electrophoresis with conductometric detectionJ Chromatogr A. (2006)
  10. ^ Okamoto A, et al. Polyamine content of ordinary foodstuffs and various fermented foodsBiosci Biotechnol Biochem. (1997)
  11. ^ Profile and levels of bioactive amines in instant coffee.
  12. ^ Ruiz-Capillas C, Jiménez-Colmenero F. Biogenic amines in meat and meat productsCrit Rev Food Sci Nutr. (2004)
  13. ^ Lorenzo JM, et al. Biogenic amine content during the manufacture of dry-cured lacón, a Spanish traditional meat product: Effect of some additivesMeat Sci. (2007)
  14. ^ Bover-Cid S, Izquierdo-Pulido M, Carmen Vidal-Carou M. Changes in biogenic amine and polyamine contents in slightly fermented sausages manufactured with and without sugarMeat Sci. (2001)
  15. ^ Consequences of high-pressure processing of vacuum-packaged frankfurters on the formation of polyamines: Effect of chilled storage.
  16. ^ Biogenic amine changes in barramundi (Lates calcarifer) slices stored at 0 °C and 4 °C.
  17. ^ Ruiz-Capillas C, Moral A. Free amino acids and biogenic amines in red and white muscle of tuna stored in controlled atmospheresAmino Acids. (2004)
  18. ^ Quality changes of anchovy (Stolephorus heterolobus) under refrigerated storage of different practical industrial methods in Thailand.
  19. ^ Profile and levels of bioactive amines in green and roasted coffee.
  20. ^ Monitoring of biologically active amines in cereals and cereal based food products by HPLC.
  21. ^ Kirschbaum J, Rebscher K, Brückner H. Liquid chromatographic determination of biogenic amines in fermented foods after derivatization with 3,5-dinitrobenzoyl chlorideJ Chromatogr A. (2000)
  22. ^ Gründemann D, et al. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)J Pharmacol Exp Ther. (2003)
  23. a b c Steer H. The source of carbon dioxide for gastric acid productionAnat Rec (Hoboken). (2009)
  24. a b Jones TZ, et al. Interactions of imidazoline ligands with the active site of purified monoamine oxidase AFEBS J. (2007)
  25. a b Remko M, Swart M, Bickelhaupt FM. Theoretical study of structure, pKa, lipophilicity, solubility, absorption, and polar surface area of some centrally acting antihypertensivesBioorg Med Chem. (2006)
  26. ^ Zhu MY, et al. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatineBiochim Biophys Acta. (2004)
  27. a b c d Raasch W, et al. Agmatine is widely and unequally distributed in rat organsAnn N Y Acad Sci. (1995)
  28. a b c d e Raasch W, et al. Agmatine, the bacterial amine, is widely distributed in mammalian tissuesLife Sci. (1995)
  29. ^ Iyer RK, et al. Cloning and characterization of human agmatinaseMol Genet Metab. (2002)
  30. ^ Mistry SK, et al. Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virusAm J Physiol Gastrointest Liver Physiol. (2002)
  31. ^ Haenisch B, et al. Regulatory mechanisms underlying agmatine homeostasis in humansAm J Physiol Gastrointest Liver Physiol. (2008)
  32. ^ Dallmann K, et al. Human agmatinase is diminished in the clear cell type of renal cell carcinomaInt J Cancer. (2004)
  33. a b c Bernstein HG, et al. Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disordersNeuropharmacology. (2012)
  34. a b Sastre M, et al. Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokinesBiochem J. (1998)
  35. ^ Haenisch B, et al. Effects of exogenous agmatine in human leukemia HMC-1 and HL-60 cells on proliferation, polyamine metabolism and cell cycleLeuk Res. (2011)
  36. ^ Regunathan S, et al. Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferationJ Pharmacol Exp Ther. (1996)
  37. ^ Gorbatyuk OS, et al. Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nucleiExp Neurol. (2001)
  38. a b c Reis DJ, Yang XC, Milner TA. Agmatine containing axon terminals in rat hippocampus form synapses on pyramidal cellsNeurosci Lett. (1998)
  39. a b c d e f Otake K, et al. Regional localization of agmatine in the rat brain: an immunocytochemical studyBrain Res. (1998)
  40. ^ Imidazoline Receptors and Their Endogenous Ligands.
  41. ^ Wang H, et al. An antibody to agmatine localizes the amine in bovine adrenal chromaffin cellsNeurosci Lett. (1995)
  42. a b Molderings GJ, et al. Gastrointestinal uptake of agmatine: distribution in tissues and organs and pathophysiologic relevanceAnn N Y Acad Sci. (2003)
  43. a b c Gilad GM, et al. Metabolism of agmatine into urea but not into nitric oxide in rat brainNeuroreport. (1996)
  44. a b Komori Y, Wallace GC, Fukuto JM. Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogsArch Biochem Biophys. (1994)
  45. a b Yokoi I, et al. Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brainNeuropharmacology. (1994)
  46. a b Sennequier N, Stuehr DJ. Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthaseBiochemistry. (1996)
  47. a b c Novotny WF, et al. Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analoguesJ Biol Chem. (1994)
  48. ^ McGrath AP, et al. A new crystal form of human diamine oxidaseActa Crystallogr Sect F Struct Biol Cryst Commun. (2010)
  49. a b c d e f Cabella C, et al. Transport and metabolism of agmatine in rat hepatocyte culturesEur J Biochem. (2001)
  50. a b Mella C, et al. Expression and localization of an agmatinase-like protein in the rat brainHistochem Cell Biol. (2010)
  51. ^ Polo LM, et al. New insight into the transcarbamylase family: the structure of putrescine transcarbamylase, a key catalyst for fermentative utilization of agmatinePLoS One. (2012)
  52. a b Satriano J, et al. Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levelsJ Biol Chem. (1998)
  53. ^ Babál P, et al. Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cellsJ Pharmacol Exp Ther. (2001)
  54. ^ Satriano J, Kelly CJ, Blantz RC. An emerging role for agmatineKidney Int. (1999)
  55. ^ Llácer JL, et al. The gene cluster for agmatine catabolism of Enterococcus faecalis: study of recombinant putrescine transcarbamylase and agmatine deiminase and a snapshot of agmatine deiminase catalyzing its reactionJ Bacteriol. (2007)
  56. ^ Wargnies B, Lauwers N, Stalon V. Structure and properties of the putrescine carbamoyltransferase of Streptococcus faecalisEur J Biochem. (1979)
  57. ^ Simon JP, Stalon V. Enzymes of agmatine degradation and the control of their synthesis in Streptococcus faecalisJ Bacteriol. (1982)
  58. ^ Biosynthesis and metabolism of arginine in bacteria.
  59. ^ Simon JP, Wargnies B, Stalon V. Control of enzyme synthesis in the arginine deiminase pathway of Streptococcus faecalisJ Bacteriol. (1982)
  60. ^ Xi H, Schneider BL, Reitzer L. Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvageJ Bacteriol. (2000)
  61. ^ TIGIER H, GRISOLIA S. INDUCTION OF CARBAMYL-P SPECIFIC OXAMATE TRANSCARBAMYLASE BY PARABANIC ACID IN A STREPTOCOCCUSBiochem Biophys Res Commun. (1965)
  62. a b c d e f Aricioglu F, Regunathan S, Piletz JE. Is agmatine an endogenous factor against stressAnn N Y Acad Sci. (2003)
  63. a b c d Piletz JE, et al. Agmatine crosses the blood-brain barrierAnn N Y Acad Sci. (2003)
  64. a b c Feng Y, Halaris AE, Piletz JE. Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detectionJ Chromatogr B Biomed Sci Appl. (1997)
  65. a b c Regunathan S, et al. Agmatine levels in the cerebrospinal fluid of normal human volunteersJ Pain Palliat Care Pharmacother. (2009)
  66. a b Jo I, et al. Low levels of plasma agmatine in the metabolic syndromeMetab Syndr Relat Disord. (2010)
  67. a b c d e f g h i j k l m Li G, et al. Agmatine: an endogenous clonidine-displacing substance in the brainScience. (1994)
  68. a b Uzbay T, et al. Increased plasma agmatine levels in patients with schizophreniaJ Psychiatr Res. (2013)
  69. a b c Halaris A, et al. Plasma agmatine and platelet imidazoline receptors in depressionAnn N Y Acad Sci. (1999)
  70. a b c d Molderings GJ, et al. Exposure of rat isolated stomach and rats in vivo to {(14)C}agmatine: accumulation in the stomach wall and distribution in various tissuesFundam Clin Pharmacol. (2002)
  71. a b c d e f g h i Li YF, et al. Antidepressant-like effect of agmatine and its possible mechanismEur J Pharmacol. (2003)
  72. a b c d Roberts JC, et al. Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouseJ Pharmacol Exp Ther. (2005)
  73. a b c Raasch W, et al. Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reactionBr J Pharmacol. (2002)
  74. a b Satriano J, et al. Polyamine transport system mediates agmatine transport in mammalian cellsAm J Physiol Cell Physiol. (2001)
  75. a b Agmatine Is Efficiently Transported by Non-Neuronal Monoamine Transporters Extraneuronal Monoamine Transporter (EMT) and Organic Cation Transporter 2 (OCT2).
  76. ^ Agmatine Is Synthesized by a Mitochondrial Arginine Decarboxylase in Rat Brain.
  77. ^ Endogenous pain modulation: Neuropharmacokinetic/dynamic studies of the endogenous NMDA receptor antagonist/NOS inhibitor, agmatine.
  78. ^ Reis DJ, Regunathan S. Agmatine: a novel neurotransmitterAdv Pharmacol. (1998)
  79. ^ Sastre M, et al. Agmatinase activity in rat brain: a metabolic pathway for the degradation of agmatineJ Neurochem. (1996)
  80. a b c Goracke-Postle CJ, et al. Release of tritiated agmatine from spinal synaptosomesNeuroreport. (2006)
  81. ^ Sastre M, Regunathan S, Reis DJ. Uptake of agmatine into rat brain synaptosomes: possible role of cation channelsJ Neurochem. (1997)
  82. ^ Goracke-Postle CJ, et al. Potassium- and capsaicin-induced release of agmatine from spinal nerve terminalsJ Neurochem. (2007)
  83. a b Goracke-Postle CJ, et al. Agmatine transport into spinal nerve terminals is modulated by polyamine analogsJ Neurochem. (2007)
  84. ^ Regunathan S, et al. Agmatine (decarboxylated arginine) is synthesized and stored in astrocytesNeuroreport. (1995)
  85. a b Zomkowski AD, Santos AR, Rodrigues AL. Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in miceProg Neuropsychopharmacol Biol Psychiatry. (2006)
  86. a b c d e Molderings GJ, et al. Dual interaction of agmatine with the rat alpha(2D)-adrenoceptor: competitive antagonism and allosteric activationBr J Pharmacol. (2000)
  87. a b c d e f g h Dias Elpo Zomkowski A, et al. Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming testBrain Res. (2004)
  88. a b c d Gibson DA, et al. Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodilBrain Res. (2002)
  89. ^ Lewin AH, et al. Molecular features associated with polyamine modulation of NMDA receptorsJ Med Chem. (1998)
  90. a b c d e f g h i j k Jiang XZ, et al. 5-HT1A/1B receptors, alpha2-adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatineYao Xue Xue Bao. (2008)
  91. a b Piletz JE, Chikkala DN, Ernsberger P. Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptorsJ Pharmacol Exp Ther. (1995)
  92. a b c Morrissey JJ, Klahr S. Agmatine activation of nitric oxide synthase in endothelial cellsProc Assoc Am Physicians. (1997)
  93. a b c d e f Chang CH, et al. Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of ratsNeurosci Lett. (2010)
  94. a b Pinthong D, et al. Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sitesBr J Pharmacol. (1995)
  95. a b c Pinthong D, et al. Agmatine recognizes alpha 2-adrenoceptor binding sites but neither activates nor inhibits alpha 2-adrenoceptorsNaunyn Schmiedebergs Arch Pharmacol. (1995)
  96. ^ Pinthong D, et al. No evidence for activation of alpha(2)-adrenoceptors by methanolic extracts of bovine brain and lung containing clonidine-displacing substanceAnn N Y Acad Sci. (2003)
  97. a b c d Taksande BG, et al. Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide YBr J Pharmacol. (2011)
  98. a b c d e f g h i j k l Zomkowski AD, et al. Agmatine produces antidepressant-like effects in two models of depression in miceNeuroreport. (2002)
  99. ^ Ozaita A, et al. Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liverBr J Pharmacol. (1997)
  100. a b Raasch W, Muhle H, Dominiak P. Modulation of MAO activity by imidazoline and guanidine derivativesAnn N Y Acad Sci. (1999)
  101. ^ Regunathan S, Meeley MP, Reis DJ. Expression of non-adrenergic imidazoline sites in chromaffin cells and mitochondrial membranes of bovine adrenal medullaBiochem Pharmacol. (1993)
  102. ^ Head GA, Mayorov DN. Imidazoline receptors, novel agents and therapeutic potentialCardiovasc Hematol Agents Med Chem. (2006)
  103. a b c d e González C, et al. Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail arteryBr J Pharmacol. (1996)
  104. ^ Molderings GJ, Göthert M. Inhibitory presynaptic imidazoline receptors on sympathetic nerves in the rabbit aorta differ from I1- and I2-imidazoline binding sitesNaunyn Schmiedebergs Arch Pharmacol. (1995)
  105. a b c d Askalany AR, et al. Effect of agmatine on heteromeric N-methyl-D-aspartate receptor channelsNeurosci Res. (2005)
  106. a b c d e f Yang XC, Reis DJ. Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neuronsJ Pharmacol Exp Ther. (1999)
  107. ^ Reynolds IJ. Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptorJ Pharmacol Exp Ther. (1990)
  108. ^ Anis N, et al. Structure-activity relationships of philanthotoxin analogs and polyamines on N-methyl-D-aspartate and nicotinic acetylcholine receptorsJ Pharmacol Exp Ther. (1990)
  109. a b c d e f g Zhu MY, et al. Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cellsCell Mol Neurobiol. (2003)
  110. ^ Brown RE, Stevens DR, Haas HL. The physiology of brain histamineProg Neurobiol. (2001)
  111. a b Burban A, et al. Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding siteJ Pharmacol Exp Ther. (2010)
  112. ^ Watanabe C, et al. Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptorsEur J Pharmacol. (2008)
  113. a b c Wade CL, et al. Immunoneutralization of agmatine sensitizes mice to micro-opioid receptor toleranceJ Pharmacol Exp Ther. (2009)
  114. ^ Lewis B, Wellmann KA, Barron S. Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposurePharmacol Biochem Behav. (2007)
  115. ^ Barron S, et al. Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependenceRecent Pat CNS Drug Discov. (2012)
  116. a b Rawls SM, Gomez T, Raffa RB. An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2)Pharmacol Biochem Behav. (2007)
  117. a b c d e f g h i Demady DR, et al. Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzymeMol Pharmacol. (2001)
  118. a b c Nishida CR, Ortiz de Montellano PR. Electron transfer and catalytic activity of nitric oxide synthases. Chimeric constructs of the neuronal, inducible, and endothelial isoformsJ Biol Chem. (1998)
  119. a b Abu-Soud HM, et al. Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reductionJ Biol Chem. (1994)
  120. ^ Alagarsamy S, Johnson KM. Voltage-dependent calcium channel involvement in NMDA-induced activation of NOSNeuroreport. (1995)
  121. a b Fairbanks CA, Wilcox GL. Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine toleranceJ Pharmacol Exp Ther. (1997)
  122. ^ Kolesnikov YA, et al. Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitorProc Natl Acad Sci U S A. (1993)
  123. a b Elliott K, et al. The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioidsPain. (1994)
  124. a b Elliott K, et al. N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug developmentNeuropsychopharmacology. (1995)
  125. ^ Loring RH. Agmatine acts as an antagonist of neuronal nicotinic receptorsBr J Pharmacol. (1990)
  126. a b c d e f Krass M, et al. Antidepressant-like effect of agmatine is not mediated by serotoninBehav Brain Res. (2008)
  127. ^ Molderings GJ, et al. Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of sigma 2 binding sitesNaunyn Schmiedebergs Arch Pharmacol. (1996)
  128. a b c d e Taksande BG, et al. Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatineNeuropharmacology. (2009)
  129. ^ Kim HS, et al. NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in PCPA-treated miceArch Pharm Res. (1999)
  130. ^ Kim HS, Son YR, Kim SH. Nitric oxide synthase inhibitors enhance 5-HT2 receptor-mediated behavior, the head-twitch response in miceLife Sci. (1999)
  131. a b Kotagale NR, et al. Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim testPharmacol Biochem Behav. (2013)
  132. a b Tsou K, et al. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous systemNeuroscience. (1998)
  133. a b Pettit DA, et al. Immunohistochemical localization of the neural cannabinoid receptor in rat brainJ Neurosci Res. (1998)
  134. a b Ruggiero DA, et al. Immunocytochemical localization of an imidazoline receptor protein in the central nervous systemBrain Res. (1998)
  135. a b Molderings GJ, Likungu J, Göthert M. Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationshipNaunyn Schmiedebergs Arch Pharmacol. (1999)
  136. a b c d e f g Aggarwal S, et al. Agmatine enhances cannabinoid action in the hot-plate assay of thermal nociceptionPharmacol Biochem Behav. (2009)
  137. a b Rawls SM, Tallarida RJ, Zisk J. Agmatine and a cannabinoid agonist, WIN 55212-2, interact to produce a hypothermic synergyEur J Pharmacol. (2006)
  138. a b Compton DR, et al. Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinolJ Pharmacol Exp Ther. (1992)
  139. a b c Thorat SN, Bhargava HN. Effects of NMDA receptor blockade and nitric oxide synthase inhibition on the acute and chronic actions of delta 9-tetrahydrocannabinol in miceBrain Res. (1994)
  140. a b Spina E, et al. A role of nitric oxide in WIN 55,212-2 tolerance in miceEur J Pharmacol. (1998)
  141. a b Molderings GJ, et al. Presynaptic imidazoline receptors and non-adrenoceptor {3H}-idazoxan binding sites in human cardiovascular tissuesBr J Pharmacol. (1997)
  142. ^ Wong CS, et al. Effects of NMDA receptor antagonists on inhibition of morphine tolerance in rats: binding at mu-opioid receptorsEur J Pharmacol. (1996)
  143. a b Li J, et al. Effects of agmatine on tolerance to and substance dependence on morphine in miceZhongguo Yao Li Xue Bao. (1999)
  144. a b Kolesnikov Y, Jain S, Pasternak GW. Modulation of opioid analgesia by agmatineEur J Pharmacol. (1996)
  145. ^ Yeşilyurt O, Uzbay IT. Agmatine potentiates the analgesic effect of morphine by an alpha(2)-adrenoceptor-mediated mechanism in miceNeuropsychopharmacology. (2001)
  146. ^ Bhalla S, Rapolaviciute V, Gulati A. Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874Eur J Pharmacol. (2011)
  147. ^ Su RB, et al. Effects of intragastric agmatine on morphine-induced physiological dependence in beagle dogs and rhesus monkeysEur J Pharmacol. (2008)
  148. ^ Gold MS, Redmond DE Jr, Kleber HD. Clonidine blocks acute opiate-withdrawal symptomsLancet. (1978)
  149. ^ Kosten TA. Clonidine attenuates conditioned aversion produced by naloxone-precipitated opiate withdrawalEur J Pharmacol. (1994)
  150. ^ Maldonado R. Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidenceNeurosci Biobehav Rev. (1997)
  151. ^ Iglesias V, et al. Effects of yohimbine on morphine analgesia and physical dependence in the ratEur J Pharmacol. (1992)
  152. ^ Dwoskin LP, Neal BS, Sparber SB. Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in ratsEur J Pharmacol. (1983)
  153. ^ Wade CL, et al. Supraspinally-administered agmatine attenuates the development of oral fentanyl self-administrationEur J Pharmacol. (2008)
  154. a b Morgan AD, et al. Effects of agmatine on the escalation of intravenous cocaine and fentanyl self-administration in ratsPharmacol Biochem Behav. (2002)
  155. ^ Huston JP, et al. What’s conditioned in conditioned place preferenceTrends Pharmacol Sci. (2013)
  156. ^ Tahsili-Fahadan P, et al. Agmatine potentiates morphine-induced conditioned place preference in mice: modulation by alpha2-adrenoceptorsNeuropsychopharmacology. (2006)
  157. a b Yu Y, et al. A nonproton ligand sensor in the acid-sensing ion channelNeuron. (2010)
  158. a b c d Li WG, et al. ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domainMol Pain. (2010)
  159. a b Wemmie JA, Price MP, Welsh MJ. Acid-sensing ion channels: advances, questions and therapeutic opportunitiesTrends Neurosci. (2006)
  160. ^ Waldmann R, et al. A proton-gated cation channel involved in acid-sensingNature. (1997)
  161. ^ de Weille JR, et al. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channelFEBS Lett. (1998)
  162. ^ Salinas M, Lazdunski M, Lingueglia E. Structural elements for the generation of sustained currents by the acid pain sensor ASIC3J Biol Chem. (2009)
  163. ^ Deval E, et al. ASIC3, a sensor of acidic and primary inflammatory painEMBO J. (2008)
  164. ^ Li WG, Xu TL. ASIC3 channels in multimodal sensory perceptionACS Chem Neurosci. (2011)
  165. ^ Zhang M, Wang H, Tracey KJ. Regulation of macrophage activation and inflammation by spermine: a new chapter in an old storyCrit Care Med. (2000)
  166. ^ Fairbanks CA, et al. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injuryProc Natl Acad Sci U S A. (2000)
  167. ^ Su RB, Li J, Qin BY. A biphasic opioid function modulator: agmatineActa Pharmacol Sin. (2003)
  168. a b c Keynan O, et al. Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled TrialPain Med. (2010)
  169. ^ Buchhalter AR, Fant RV, Henningfield JE. Novel pharmacological approaches for treating tobacco dependence and withdrawal: current statusDrugs. (2008)
  170. ^ Gourlay S, et al. A placebo-controlled study of three clonidine doses for smoking cessationClin Pharmacol Ther. (1994)
  171. ^ Yamanaka K, Oshita M, Muramatsu I. Alteration of alpha and muscarinic receptors in rat brain and heart following chronic nicotine treatmentBrain Res. (1985)
  172. a b Kotagale NR, et al. Repeated agmatine treatment attenuates nicotine sensitization in mice: modulation by alpha2-adrenoceptorsBehav Brain Res. (2010)
  173. ^ Zaniewska M, et al. Effects of agmatine on nicotine-evoked behavioral responses in ratsPharmacol Rep. (2008)
  174. ^ Uzbay IT, et al. Effects of agmatine on ethanol withdrawal syndrome in ratsBehav Brain Res. (2000)
  175. a b c d e Taksande BG, et al. Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in ratsEur J Pharmacol. (2010)
  176. ^ Littleton JM, et al. Role of polyamines and NMDA receptors in ethanol dependence and withdrawalAlcohol Clin Exp Res. (2001)
  177. ^ Gibson DA, et al. Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptorAlcohol Clin Exp Res. (2003)
  178. ^ Collins ED, et al. The effects of memantine on the subjective, reinforcing and cardiovascular effects of cocaine in humansBehav Pharmacol. (1998)
  179. ^ Collins ED, et al. The effects of acute pretreatment with high-dose memantine on the cardiovascular and behavioral effects of cocaine in humansExp Clin Psychopharmacol. (2007)
  180. ^ Rawls SM, et al. A nitric oxide synthase inhibitor (L-NAME) attenuates abstinence-induced withdrawal from both cocaine and a cannabinoid agonist (WIN 55212-2) in PlanariaBrain Res. (2006)
  181. a b Cantin L, et al. Cocaine is low on the value ladder of rats: possible evidence for resilience to addictionPLoS One. (2010)
  182. ^ Lenoir M, et al. Intense sweetness surpasses cocaine rewardPLoS One. (2007)
  183. a b c d Wang CC, et al. Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemiaBMC Pharmacol. (2010)
  184. a b Agmatine reduced the expressions of nitric oxide synthase and peroxynitrite formation in rat cerebral cortex after transient global cerebral ischemia.
  185. a b c Kim JH, et al. Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemiaJ Cereb Blood Flow Metab. (2010)
  186. a b c Lee WT, et al. Neuroprotective effects of agmatine on oxygen-glucose deprived primary-cultured astrocytes and nuclear translocation of nuclear factor-kappa BBrain Res. (2009)
  187. ^ Kim JH, et al. Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injuryExp Neurol. (2004)
  188. a b c Feng Y, Piletz JE, Leblanc MH. Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal ratsPediatr Res. (2002)
  189. ^ Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injuryTrends Neurosci. (1997)
  190. ^ Moro MA, et al. Role of nitric oxide after brain ischaemiaCell Calcium. (2004)
  191. ^ Raghavan SA, Dikshit M. Vascular regulation by the L-arginine metabolites, nitric oxide and agmatinePharmacol Res. (2004)
  192. ^ Huang Z, et al. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthaseScience. (1994)
  193. ^ Mun CH, et al. Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brainAnat Cell Biol. (2010)
  194. ^ Ma T, et al. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4J Clin Invest. (1997)
  195. ^ Manley GT, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic strokeNat Med. (2000)
  196. ^ Ribeiro Mde C, et al. Time course of aquaporin expression after transient focal cerebral ischemia in miceJ Neurosci Res. (2006)
  197. ^ Gilad GM, et al. Agmatine treatment is neuroprotective in rodent brain injury modelsLife Sci. (1996)
  198. ^ Panet H, et al. Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cellsJ Neurochem. (2001)
  199. a b Seo SK, et al. Overexpression of human arginine decarboxylase rescues human mesenchymal stem cells against H₂O₂ toxicity through cell survival protein activationJ Korean Med Sci. (2013)
  200. a b c Santhanam AV, Viswanathan S, Dikshit M. Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxationEur J Pharmacol. (2007)
  201. ^ Li W, et al. An essential role for the Id1/PI3K/Akt/NFkB/survivin signalling pathway in promoting the proliferation of endothelial progenitor cells in vitroMol Cell Biochem. (2012)
  202. ^ Kanwar JR, Kamalapuram SK, Kanwar RK. Targeting survivin in cancer: the cell-signalling perspectiveDrug Discov Today. (2011)
  203. ^ Lin J, et al. Inhibitor of differentiation 1 contributes to head and neck squamous cell carcinoma survival via the NF-kappaB/survivin and phosphoinositide 3-kinase/Akt signaling pathwaysClin Cancer Res. (2010)
  204. ^ Young ND, Galston AW. Putrescine and Acid Stress : Induction of Arginine Decarboxylase Activity and Putrescine Accumulation by Low pHPlant Physiol. (1983)
  205. ^ Bliven KA, Fisher DJ, Maurelli AT. Characterization of the activity and expression of arginine decarboxylase in human and animal Chlamydia pathogensFEMS Microbiol Lett. (2012)
  206. ^ Pothipongsa A, Jantaro S, Incharoensakdi A. Polyamines induced by osmotic stress protect Synechocystis sp. PCC 6803 cells and arginine decarboxylase transcripts against UV-B radiationAppl Biochem Biotechnol. (2012)
  207. ^ Xu X, Shi G, Jia R. Changes of polyamine levels in roots of Sagittaria sagittifolia L. under copper stressEnviron Sci Pollut Res Int. (2011)
  208. a b Ruiz-Durántez E, et al. Effect of agmatine on locus coeruleus neuron activity: possible involvement of nitric oxideBr J Pharmacol. (2002)
  209. ^ Weiss JM, et al. Depression and anxiety: role of the locus coeruleus and corticotropin-releasing factorBrain Res Bull. (1994)
  210. a b Lavinsky D, Arteni NS, Netto CA. Agmatine induces anxiolysis in the elevated plus maze task in adult ratsBehav Brain Res. (2003)
  211. a b c d e Aricioglu F, Altunbas H. Is agmatine an endogenous anxiolytic/antidepressant agentAnn N Y Acad Sci. (2003)
  212. a b Gong ZH, et al. Anxiolytic effect of agmatine in rats and miceEur J Pharmacol. (2006)
  213. ^ Halaris A, Piletz JE. Relevance of imidazoline receptors and agmatine to psychiatry: a decade of progressAnn N Y Acad Sci. (2003)
  214. ^ Kaster MP, et al. Effects of potassium channel inhibitors in the forced swimming test: possible involvement of L-arginine-nitric oxide-soluble guanylate cyclase pathwayBehav Brain Res. (2005)
  215. ^ Zomkowski AD, Santos AR, Rodrigues AL. Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming testNeurosci Lett. (2005)
  216. a b c d Budni J, et al. Role of different types of potassium channels in the antidepressant-like effect of agmatine in the mouse forced swimming testEur J Pharmacol. (2007)
  217. ^ Fluoxetine inhibits A-type potassium currents in primary cultured rat hippocampal neurons.
  218. ^ Differential blockade of neuronal voltage-gated Na+ and K+ channels by antidepressant drugs.
  219. ^ Inhibition of G Protein-Activated Inwardly Rectifying K+ Channels by Phencyclidine.
  220. ^ Kobayashi T, Washiyama K, Ikeda K. Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugsNeuropsychopharmacology. (2004)
  221. ^ Kaster MP, et al. The inhibition of different types of potassium channels underlies the antidepressant-like effect of adenosine in the mouse forced swimming testProg Neuropsychopharmacol Biol Psychiatry. (2007)
  222. ^ Budni J, et al. Role of potassium channels in the antidepressant-like effect of folic acid in the forced swimming test in micePharmacol Biochem Behav. (2012)
  223. ^ Redrobe JP, Pinot P, Bourin M. The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in miceFundam Clin Pharmacol. (1996)
  224. ^ Bortolatto CF, et al. Involvement of potassium channels in the antidepressant-like effect of venlafaxine in miceLife Sci. (2010)
  225. ^ Kelly JS, et al. Serotonin receptor heterogeneity and the role of potassium channels in neuronal excitabilityAdv Exp Med Biol. (1991)
  226. a b c Weng XC, et al. Agmatine blocked voltage-gated calcium channel in cultured rat hippocampal neuronsActa Pharmacol Sin. (2003)
  227. a b The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study.
  228. ^ Pedrazzini T, Pralong F, Grouzmann E. Neuropeptide Y: the universal soldierCell Mol Life Sci. (2003)
  229. ^ Kask A, Rägo L, Harro J. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226Br J Pharmacol. (1998)
  230. ^ Huguet F, et al. Age-related changes of noradrenergic-NPY interaction in rat brain: norepinephrine, NPY levels and alpha-adrenoceptorsBrain Res. (1993)
  231. ^ Sawchenko PE, et al. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamusJ Comp Neurol. (1985)
  232. ^ Everitt BJ, et al. Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the ratNeuroscience. (1984)
  233. ^ Franco-Cereceda A, et al. Differential effects of clonidine and reserpine treatment on neuropeptide Y content in some sympathetically innervated tissues of the guinea-pigEur J Pharmacol. (1987)
  234. ^ Smiałowska M, et al. Clonidine administration increases neuropeptide Y immunoreactivity and neuropeptide Y mRNA in the rat cerebral cortex neuronsNeuropeptides. (1997)
  235. ^ Clark JT, et al. Alpha 2-adrenoceptor blockade attenuates feeding behavior induced by neuropeptide Y and epinephrinePhysiol Behav. (1988)
  236. ^ Heilig M, Wahlestedt C, Widerlöv E. Neuropeptide Y (NPY)-induced suppression of activity in the rat: evidence for NPY receptor heterogeneity and for interaction with alpha-adrenoceptorsEur J Pharmacol. (1988)
  237. ^ Prasad A, Prasad C. Agmatine enhances caloric intake and dietary carbohydrate preference in satiated ratsPhysiol Behav. (1996)
  238. a b Seo S, Liu P, Leitch B. Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminalsNeuroscience. (2011)
  239. a b Betancourt L, et al. In vivo monitoring of cerebral agmatine by microdialysis and capillary electrophoresisJ Chromatogr B Analyt Technol Biomed Life Sci. (2012)
  240. a b Liu P, et al. Spatial learning results in elevated agmatine levels in the rat brainHippocampus. (2008)
  241. ^ Leitch B, et al. Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapsesSynapse. (2011)
  242. a b c Rushaidhi M, et al. Participation of hippocampal agmatine in spatial learning: an in vivo microdialysis studyNeuropharmacology. (2013)
  243. ^ Wang ZM, et al. Effects of agmatine on neuronal discharges in rat hippocampal CA1 areaSheng Li Xue Bao. (2003)
  244. a b Liu P, et al. Memory-related changes in L-citrulline and agmatine in the rat brainHippocampus. (2009)
  245. a b c d Arteni NS, et al. Agmatine facilitates memory of an inhibitory avoidance task in adult ratsNeurobiol Learn Mem. (2002)
  246. a b Zhou HC, et al. Activation of β2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of ratsLearn Mem. (2013)
  247. a b Dalley JW, Cardinal RN, Robbins TW. Prefrontal executive and cognitive functions in rodents: neural and neurochemical substratesNeurosci Biobehav Rev. (2004)
  248. a b Gaffan D, Parker A. Interaction of perirhinal cortex with the fornix-fimbria: memory for objects and “object-in-place” memoryJ Neurosci. (1996)
  249. ^ Riccio A, et al. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neuronsScience. (1999)
  250. ^ Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKBJ Biol Chem. (1998)
  251. ^ Chen X, et al. Ischemic rat brain extracts induce human marrow stromal cell growth factor productionNeuropathology. (2002)
  252. ^ Lu Y, Christian K, Lu B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memoryNeurobiol Learn Mem. (2008)
  253. ^ Collingridge GL, Bliss TV. Memories of NMDA receptors and LTPTrends Neurosci. (1995)
  254. ^ Cain DP. LTP, NMDA, genes and learningCurr Opin Neurobiol. (1997)
  255. ^ Hawkins RD, Son H, Arancio O. Nitric oxide as a retrograde messenger during long-term potentiation in hippocampusProg Brain Res. (1998)
  256. ^ Yananli H, et al. Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: a microdialysis study in nucleus accumbensBrain Res. (2007)
  257. ^ Rastegar K, et al. The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in RatIran Red Crescent Med J. (2011)
  258. a b Stewart LS, McKay BE. Acquisition deficit and time-dependent retrograde amnesia for contextual fear conditioning in agmatine-treated ratsBehav Pharmacol. (2000)
  259. a b McKay BE, et al. Learning and memory in agmatine-treated ratsPharmacol Biochem Behav. (2002)
  260. a b c d Rushaidhi M, et al. Agmatine selectively improves behavioural function in aged male Sprague-Dawley ratsNeuroscience. (2012)
  261. a b c Liu P, et al. Behavioral effects of intracerebroventricular microinfusion of agmatine in adult ratsBehav Neurosci. (2008)
  262. ^ Liu P, Collie ND. Behavioral effects of agmatine in naive rats are task- and delay-dependentNeuroscience. (2009)
  263. ^ Szabó C. Physiological and pathophysiological roles of nitric oxide in the central nervous systemBrain Res Bull. (1996)
  264. a b c Demehri S, et al. Agmatine exerts anticonvulsant effect in mice: modulation by alpha 2-adrenoceptors and nitric oxideNeuropharmacology. (2003)
  265. a b c Bence AK, et al. An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatinePharmacol Biochem Behav. (2003)
  266. a b Luszczki JJ, et al. Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure modelJ Neural Transm. (2008)
  267. ^ Anticonvulsive effect of agmatine in mice.
  268. ^ Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
  269. ^ Garthwaite J, Charles SL, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brainNature. (1988)
  270. ^ Schoemaker H. Polyamines allosterically modulate {3H}nitrendipine binding to the voltage-sensitive calcium channel in rat brainEur J Pharmacol. (1992)
  271. ^ Jeong SY, et al. Nitric oxide directly activates large conductance Ca2+-activated K+ channels (rSlo)Mol Cells. (2001)
  272. ^ Shin JH, et al. Nitric oxide directly activates calcium-activated potassium channels from rat brain reconstituted into planar lipid bilayerFEBS Lett. (1997)
  273. ^ Denninger JW, Marletta MA. Guanylate cyclase and the .NO/cGMP signaling pathwayBiochim Biophys Acta. (1999)
  274. a b Bhutada P, et al. Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic ratsProg Neuropsychopharmacol Biol Psychiatry. (2012)
  275. a b c d e f g Hwang SL, et al. Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic ratsDiabetologia. (2005)
  276. ^ Bergin DH, Liu P. Agmatine protects against beta-amyloid25-35-induced memory impairments in the ratNeuroscience. (2010)
  277. ^ Matheus FC, et al. Neuroprotective effects of agmatine in mice infused with a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)Behav Brain Res. (2012)
  278. ^ Moosavi M, et al. Agmatine protects against scopolamine-induced water maze performance impairment and hippocampal ERK and Akt inactivationNeuropharmacology. (2012)
  279. ^ Utkan T, et al. Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in ratsPharmacol Biochem Behav. (2012)
  280. ^ Zarifkar A, et al. Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosisEur J Pharmacol. (2010)
  281. ^ Ahn SK, et al. Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activityLife Sci. (2012)
  282. a b Kohl S, et al. Prepulse inhibition in psychiatric disorders–apart from schizophreniaJ Psychiatr Res. (2013)
  283. ^ Geyer MA, et al. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in reviewPsychopharmacology (Berl). (2001)
  284. ^ Giakoumaki SG. Cognitive and prepulse inhibition deficits in psychometrically high schizotypal subjects in the general population: relevance to schizophrenia researchJ Int Neuropsychol Soc. (2012)
  285. a b Uzbay T, et al. Agmatine disrupts prepulse inhibition of acoustic startle reflex in ratsJ Psychopharmacol. (2010)
  286. ^ Pålsson E, et al. Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibitionEur J Pharmacol. (2008)
  287. ^ Kotagale NR, et al. Psychopharmacological study of agmatine in behavioral tests of schizophrenia in rodentsPharmacol Biochem Behav. (2012)
  288. ^ Liu P, et al. Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortexNeurobiol Aging. (2004)
  289. ^ Liu P, et al. Effects of aging on agmatine levels in memory-associated brain structuresHippocampus. (2008)
  290. ^ Liu P, et al. Age-related changes in polyamines in memory-associated brain structures in ratsNeuroscience. (2008)
  291. ^ Gupta N, et al. Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley ratsNeuroscience. (2012)
  292. ^ Liu P, et al. Potential involvement of NOS and arginase in age-related behavioural impairmentsExp Gerontol. (2004)
  293. ^ Liu P, et al. Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficitsHippocampus. (2005)
  294. ^ Rushaidhi M, Zhang H, Liu P. Effects of prolonged agmatine treatment in aged male Sprague-Dawley ratsNeuroscience. (2013)
  295. a b c d e f Joshi MS, et al. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cellsProc Natl Acad Sci U S A. (2007)
  296. a b Haulică I, et al. Preliminary research on possible relationship of NO with agmatine at the vascular levelRom J Physiol. (1999)
  297. a b c d e Schwartz D, et al. Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanismAm J Physiol. (1997)
  298. ^ Fill M, Copello JA. Ryanodine receptor calcium release channelsPhysiol Rev. (2002)
  299. ^ Nitric Oxide-induced Mobilization of Intracellular Calcium via the Cyclic ADP-ribose Signaling Pathway.
  300. ^ Stoyanovsky D, et al. Nitric oxide activates skeletal and cardiac ryanodine receptorsCell Calcium. (1997)
  301. ^ Galione A, Lee HC, Busa WB. Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-riboseScience. (1991)
  302. ^ Lee HC, Galione A, Walseth TF. Cyclic ADP-ribose: metabolism and calcium mobilizing functionVitam Horm. (1994)
  303. a b c d e Satriano J, et al. Effects on kidney filtration rate by agmatine requires activation of ryanodine channels for nitric oxide generationAm J Physiol Renal Physiol. (2008)
  304. ^ Jagnandan D, Sessa WC, Fulton D. Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOSAm J Physiol Cell Physiol. (2005)
  305. ^ Liou SF, et al. The vasorelaxing action of labedipinedilol-A involves endothelial cell-derived NO and eNOS expression caused by calcium influxJ Cardiovasc Pharmacol. (2005)
  306. ^ eNOS at a glance.
  307. ^ Kakizawa S, Yamazawa T, Iino M. Nitric oxide-induced calcium release: activation of type 1 ryanodine receptor by endogenous nitric oxideChannels (Austin). (2013)
  308. ^ Chen CT, et al. Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscleHorm Metab Res. (2011)
  309. ^ Yamboliev IA, Mutafova-Yambolieva VN. PI3K and PKC contribute to membrane depolarization mediated by alpha2-adrenoceptors in the canine isolated mesenteric veinBMC Physiol. (2005)
  310. ^ Lu XL, et al. Marine cyclotripeptide X-13 promotes angiogenesis in zebrafish and human endothelial cells via PI3K/Akt/eNOS signaling pathwaysMar Drugs. (2012)
  311. ^ Shi F, et al. Effects of simulated microgravity on human umbilical vein endothelial cell angiogenesis and role of the PI3K-Akt-eNOS signal pathwayPLoS One. (2012)
  312. ^ Jung HJ, et al. Agmatine promotes the migration of murine brain endothelial cells via multiple signaling pathwaysLife Sci. (2013)
  313. a b Auguet M, et al. Selective inhibition of inducible nitric oxide synthase by agmatineJpn J Pharmacol. (1995)
  314. ^ Jianmongkol S, et al. Aminoguanidine-mediated inactivation and alteration of neuronal nitric-oxide synthaseJ Biol Chem. (2000)
  315. ^ Wolff DJ, Lubeskie A. Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthaseArch Biochem Biophys. (1995)
  316. ^ Nakatsuka M, Nakatsuka K, Osawa Y. Metabolism-based inactivation of penile nitric oxide synthase activity by guanabenzDrug Metab Dispos. (1998)
  317. ^ Li Q, et al. Effect of agmatine on intracellular free calcium concentration in isolated rat ventricular myocytesSheng Li Xue Bao. (2002)
  318. ^ Li Q, Yin JX, He RR. Effect of agmatine on L-type calcium current in rat ventricular myocytesActa Pharmacol Sin. (2002)
  319. a b c d Lortie MJ, et al. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the ratJ Clin Invest. (1996)
  320. ^ Gao Y, et al. Agmatine: a novel endogenous vasodilator substanceLife Sci. (1995)
  321. ^ Ishikawa T, et al. N omega-hydroxyagmatine: a novel substance causing endothelium-dependent vasorelaxationBiochem Biophys Res Commun. (1995)
  322. ^ Gill F, et al. Effects of agmatine on the survival rate in rats bled to hemorrhageArzneimittelforschung. (2011)
  323. ^ Ernsberger P, et al. Hypotensive action of clonidine analogues correlates with binding affinity at imidazole and not alpha-2-adrenergic receptors in the rostral ventrolateral medullaJ Hypertens Suppl. (1988)
  324. ^ Ernsberger P, et al. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medullaJ Pharmacol Exp Ther. (1990)
  325. ^ Jou SB, Liu IM, Cheng JT. Activation of imidazoline receptor by agmatine to lower plasma glucose in streptozotocin-induced diabetic ratsNeurosci Lett. (2004)
  326. ^ Schäfer U, et al. Effects of agmatine on the cardiovascular system of spontaneously hypertensive ratsAnn N Y Acad Sci. (1999)
  327. ^ Sun MK, Regunathan S, Reis DJ. Cardiovascular responses to agmatine, a clonidine-displacing substance, in anesthetized ratClin Exp Hypertens. (1995)
  328. ^ Khan S, et al. Beta-endorphin decreases fatigue and increases glucose uptake independently in normal and dystrophic miceMuscle Nerve. (2005)
  329. ^ Cheng JT, et al. Plasma glucose-lowering effect of beta-endorphin in streptozotocin-induced diabetic ratsHorm Metab Res. (2002)
  330. a b Evans AA, Khan S, Smith ME. Evidence for a hormonal action of beta-endorphin to increase glucose uptake in resting and contracting skeletal muscleJ Endocrinol. (1997)
  331. ^ Radosevich PM, et al. Beta-endorphin inhibits glucose production in the conscious dogJ Clin Invest. (1984)
  332. ^ Curry DL, Bennett LL, Li CH. Stimulation of insulin secretion by beta-endorphins (1-27 & 1-31)Life Sci. (1987)
  333. ^ Hauner H, et al. Endogenous opiates do not influence glucose and lipid metabolism in rat adipocytesExp Clin Endocrinol. (1988)
  334. ^ Kalra SP, et al. Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitroNeurosci Lett. (1995)
  335. ^ Hong S, et al. Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell lineBMC Neurosci. (2007)
  336. ^ Hong S, et al. Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat modelExp Eye Res. (2010)
  337. ^ Hong S, et al. Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic arteryBraz J Med Biol Res. (2012)
  338. ^ Al Masri AA, El Eter E. Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in ratsWorld J Gastroenterol. (2012)
  339. a b Utkan T, et al. Investigation on the mechanism involved in the effects of agmatine on ethanol-induced gastric mucosal injury in ratsLife Sci. (2000)
  340. ^ Glavin GB, Smyth DD. Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in ratsBr J Pharmacol. (1995)
  341. ^ Glavin GB, Carlisle MA, Smyth DD. Agmatine, an endogenous imidazoline receptor agonist, increases gastric secretion and worsens experimental gastric mucosal injury in ratsJ Pharmacol Exp Ther. (1995)
  342. ^ Zádori ZS, et al. Imidazoline versus alpha2-adrenoceptors in the control of gastric motility in miceEur J Pharmacol. (2013)
  343. ^ Molderings GJ, et al. Potential relevance of agmatine as a virulence factor of Helicobacter pyloriDig Dis Sci. (1999)
  344. ^ Bidet M, et al. Video microscopy of intracellular pH in primary cultures of rabbit proximal and early distal tubulesPflugers Arch. (1990)
  345. a b Jurkiewicz NH, et al. Functional properties of agmatine in rat vas deferensEur J Pharmacol. (1996)
  346. a b Santos WC, et al. Dual effect of agmatine in the bisected rat vas deferensJ Pharm Pharmacol. (2003)
  347. ^ Presta A, et al. Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activityNitric Oxide. (1997)
  348. ^ Aglawe MM, et al. Participation of central imidazoline binding sites in antinociceptive effect of ethanol and nicotine in ratsFundam Clin Pharmacol. (2013)
  349. ^ Ozden O, et al. Agmatine blocks ethanol-induced locomotor hyperactivity in male miceEur J Pharmacol. (2011)
  350. ^ Sameer SM, Chakraborty SS, Ugale RR. Agmatine attenuates acquisition but not the expression of ethanol conditioned place preference in mice: a role for imidazoline receptorsBehav Pharmacol. (2013)
  351. ^ Uzbay T, et al. Sex-related effects of agmatine on caffeine-induced locomotor activity in Swiss Webster miceEur J Pharmacol. (2010)
  352. ^ MATERIAL SAFETY DATA SHEET Agmatine.