Pelargonium Sidoides

Pelargonium Sidoides, Géranium africain

Pelargonium Sidoides is a type of herb indicated for treating acute and chronic infections of the respiratory tract and ear, nose and throat infections such as rhinopharyngitis, tonsillitis, sinusitis and bronchitis.


  • Origine À base de plante
  • Source elle-même
  • Type Produits phytochimiques, bioflavonoïdes


Le système immunitaire est constitué de cellules, de tissus et d’organes qui agissent dans la défense de l’organisme contre les effets nocifs des microorganismes externes. Les suppléments indiqués pour l’immunité agissent comme des agents de renforcement de ce système, augmentant la production d’anticorps et, par conséquent, son activité de défense.
  • Réponse immunitaire

    La réponse immunitaire est mesurée par la vitesse et l’efficacité du système immunitaire peut neutraliser tout type de maladie, qu’il s’agisse de virus, de bactéries ou d’autres pathogènes.
  • Groupe d´âge Enfants (0-12), Adolescents (13-19), Adultes (20-59), Aînés (>60)
  • Toxicité Il n’y a aucune preuve de toxicité jusqu’à présent
  • Effects secondaires Troubles gastro-intestinaux
  • Avertissements Maladies hépatiques

Pourquoi faire attention

Le Sidoides de Pelargonium semble être très bien toléré par la plupart des études de groupe, il pourrait y avoir des bouleversements gastro-intestinaux si pris à des doses élevées, mais il peut être fixé en mettant fin à la supplémentation. Il pourrait y avoir des interactions avec la surcharge hépatique chez les personnes atteintes de maladies du foie, mais d’autres recherches sont nécessaires pour le confirmer.


  1. a b Moyo M, et al. Conservation strategy for Pelargonium sidoides DC: Phenolic profile and pharmacological activity of acclimatized plants derived from tissue cultureJ Ethnopharmacol. (2013)
  2. ^ van Wyk BE. A broad review of commercially important southern African medicinal plantsJ Ethnopharmacol. (2008)
  3. a b c d e f g h i j k l m n o p q r s t u v w x y Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine UmckaloaboPhytomedicine. (2007)
  4. a b Colling J, Groenewald JH, Makunga NP. Genetic alterations for increased coumarin production lead to metabolic changes in the medicinally important Pelargonium sidoides DC (Geraniaceae)Metab Eng. (2010)
  5. ^ Brendler T, van Wyk BE. A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae)J Ethnopharmacol. (2008)
  6. a b Unusual coumarin patterns of Pelargonium species forming the origin of the traditional herbal medicine umckaloabo.
  7. a b c Tabali M, et al. Adverse drug reactions for CAM and conventional drugs detected in a network of physicians certified to prescribe CAM drugsJ Manag Care Pharm. (2012)
  8. ^ Pelargonium sidoides – oral (Kaloban)..
  9. a b c The leaves of Pelargonium sidoides may substitute for its roots in the treatment of bacterial infections.
  10. a b c d e f Kolodziej H, et al. Pharmacological profile of extracts of Pelargonium sidoides and their constituentsPhytomedicine. (2003)
  11. a b c d Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniformePlanta Med. (1997)
  12. ^ Highly oxygenated coumarins from Pelargonium sidoides.
  13. ^ Hauer H, et al. Benzopyranones and their sulfate esters from Pelargonium sidoidesPlanta Med. (2010)
  14. a b c d e Theisen LL, Muller CP. EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivoAntiviral Res. (2012)
  15. a b c Janecki A, Kolodziej H. Anti-adhesive activities of flavan-3-ols and proanthocyanidins in the interaction of group A-streptococci and human epithelial cellsMolecules. (2010)
  16. ^ Foo LY, et al. The phenols and prodelphinidins of white clover flowersPhytochemistry. (2000)
  17. ^ Prodelphinidins from Ribes nigrum.
  18. a b c Schötz K, Nöldner M. Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs 7630) and pharmacological screening in CNS modelsPhytomedicine. (2007)
  19. ^ Phytochemical distinction between Pelargonium sidoides and Pelargonium reniforme — A quality control perspective.
  20. a b c d e f g h Matthys H, et al. Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trialPhytomedicine. (2003)
  21. a b c Matthys H, et al. Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPDRespir Med. (2013)
  22. a b Matthys H, et al. Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoidesCurr Med Res Opin. (2010)
  23. ^ Schoetz K, et al. A detailed view on the constituents of EPs 7630Planta Med. (2008)
  24. ^ Franco L, de Oliveira BH. Determination of umckalin in commercial tincture and phytopreparations containing Pelargonium sidoides by HPLC: comparison of sample preparation proceduresTalanta. (2010)
  25. a b c d e f Luna LA Jr, et al. Immune responses induced by Pelargonium sidoides extract in serum and nasal mucosa of athletes after exhaustive exercise: modulation of secretory IgA, IL-6 and IL-15Phytomedicine. (2011)
  26. ^ Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarinPhytomedicine. (2007)
  27. ^ Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistanceAnnu Rev Pharmacol. (1969)
  28. ^ Panossian A, Wikman G, Wagner H. Plant adaptogens. III. Earlier and more recent aspects and concepts on their mode of actionPhytomedicine. (1999)
  29. ^ Adaptogens: Tonic Herbs for Fatigue and Stress.
  30. a b Asea A, et al. Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extractsPhytomedicine. (2013)
  31. a b c Patiroglu T, et al. The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancyPhytomedicine. (2012)
  32. a b Tahan F, Yaman M. Can the Pelargonium sidoides root extract EPs® 7630 prevent asthma attacks during viral infections of the upper respiratory tract in childrenPhytomedicine. (2013)
  33. ^ Matthys H, Heger M. Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre studyCurr Med Res Opin. (2007)
  34. ^ Matthys H, Funk P. EPs 7630 improves acute bronchitic symptoms and shortens time to remission. Results of a randomised, double-blind, placebo-controlled, multicentre trialPlanta Med. (2008)
  35. a b c d e f g Matthys H, et al. Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and childrenPhytomedicine. (2007)
  36. a b Chuchalin AG, Berman B, Lehmacher W. Treatment of acute bronchitis in adults with a pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trialExplore (NY). (2005)
  37. a b c Matthys H, Heger M. EPs 7630-solution–an effective therapeutic option in acute and exacerbating bronchitisPhytomedicine. (2007)
  38. a b c Lizogub VG, Riley DS, Heger M. Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trialExplore (NY). (2007)
  39. a b c d Kamin W, et al. Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitisActa Paediatr. (2010)
  40. a b c d Kamin W, et al. Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescentsPediatr Int. (2012)
  41. ^ Gleeson M. Mucosal immunity and respiratory illness in elite athletesInt J Sports Med. (2000)
  42. ^ Mackinnon LT, Hooper S. Mucosal (secretory) immune system responses to exercise of varying intensity and during overtrainingInt J Sports Med. (1994)
  43. ^ Pal M, Febbraio MA, Whitham M. From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulationImmunol Cell Biol. (2014)
  44. a b Thäle C, Kiderlen AF, Kolodziej H. Anti-infective activities of Pelargonium sidoides (EPS® 7630): effects of induced NO production on Leishmania major in infected macrophages and antiviral effects as assessed in a fibroblast-virus protection assayPlanta Med. (2011)
  45. ^ Kayser O, Kolodziej H, Kiderlen AF. Immunomodulatory principles of Pelargonium sidoidesPhytother Res. (2001)
  46. ^ Trun W, Kiderlen AF, Kolodziej H. Nitric oxide synthase and cytokines gene expression analyses in Leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (Eps 7630)Phytomedicine. (2006)
  47. ^ Thäle C, Kiderlen A, Kolodziej H. Anti-infective mode of action of EPs 7630 at the molecular levelPlanta Med. (2008)
  48. ^ Kim CE, Griffiths WJ, Taylor PW. Components derived from Pelargonium stimulate macrophage killing of Mycobacterium speciesJ Appl Microbiol. (2009)
  49. ^ Kobayashi SD, et al. Neutrophils in the innate immune responseArch Immunol Ther Exp (Warsz). (2005)
  50. a b Conrad A, et al. Extract of Pelargonium sidoides (EPs 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitroPhytomedicine. (2007)
  51. ^ Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adultsAm Fam Physician. (2012)
  52. ^ Labuschagné A, et al. Synergistic Antimycobacterial Actions of Knowltonia vesicatoria (L.f) SimsEvid Based Complement Alternat Med. (2012)
  53. a b c d Conrad A, et al. Extract of Pelargonium sidoides (EPs 7630) inhibits the interactions of group A-streptococci and host epithelia in vitroPhytomedicine. (2007)
  54. a b c d Janecki A, et al. Evaluation of an aqueous-ethanolic extract from Pelargonium sidoides (EPs® 7630) for its activity against group A-streptococci adhesion to human HEp-2 epithelial cellsJ Ethnopharmacol. (2011)
  55. ^ Oligomeric flavan-3-ols from medicinal willow bark.
  56. ^ Procyanidins from medicinal birch: bonding patterns and sequence of units in triflavanoids of mixed stereochemistry.
  57. ^ Occurrence of procyanidins in Nelia meyeri.
  58. ^ Sethman CR, Doyle RJ, Cowan MM. Flow cytometric evaluation of adhesion of Streptococcus pyogenes to epithelial cellsJ Microbiol Methods. (2002)
  59. ^ Keles S, et al. Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: ‘similarities and differences’Pediatr Allergy Immunol. (2010)
  60. a b Bachert C, et al. Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trialRhinology. (2009)
  61. a b c Michaelis M, Doerr HW, Cinatl J Jr. Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory virusesPhytomedicine. (2011)
  62. ^ Gonzales R, Sande MA. Uncomplicated acute bronchitisAnn Intern Med. (2000)
  63. a b Schnitzler P, et al. Efficacy of an aqueous Pelargonium sidoides extract against herpesvirusPhytomedicine. (2008)
  64. ^ Wittschier N, et al. Large molecules as anti-adhesive compounds against pathogensJ Pharm Pharmacol. (2007)
  65. a b Wittschier N, Faller G, Hensel A. An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomachPhytomedicine. (2007)
  66. ^ Beil W, Kilian P. EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cellsPhytomedicine. (2007)
  67. a b c d Knutson D, Braun C. Diagnosis and management of acute bronchitisAm Fam Physician. (2002)
  68. ^ Flaherty KR, et al. The spectrum of acute bronchitis. Using baseline factors to guide empirical therapyPostgrad Med. (2001)
  69. ^ Hueston WJ, Mainous AG 3rd. Acute bronchitisAm Fam Physician. (1998)
  70. ^ Slusarcick AL, McCaig LF. National Hospital Ambulatory Medical Care Survey: 1998 outpatient department summaryAdv Data. (2000)
  71. ^ Smucny J, et al. Antibiotics for acute bronchitisCochrane Database Syst Rev. (2000)
  72. ^ Matthys H, Kamin W. Positioning of the Bronchitis Severity Score (BSS) for standardised use in clinical studiesCurr Med Res Opin. (2013)
  73. ^ Agbabiaka TB, Guo R, Ernst E. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysisPhytomedicine. (2008)
  74. ^ Rabe KF, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summaryAm J Respir Crit Care Med. (2007)
  75. ^ Jones PW, et al. A self-complete measure of health status for chronic airflow limitation. The St. George’s Respiratory QuestionnaireAm Rev Respir Dis. (1992)
  76. ^ Teschke R, et al. Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: was causality adequately ascertainedRegul Toxicol Pharmacol. (2012)
  77. ^ Teschke R, et al.  Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvementAnn Hepatol. (2012)
  78. a b de Boer HJ, et al. Allergic reactions to medicines derived from Pelargonium speciesDrug Saf. (2007)
  79. Kamin W, et al. Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis – a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides rootsInt J Clin Pharmacol Ther. (2010)