Raspberry Ketone

Raspberry Ketone, 4-(4-hydroxyphenyl) butan-2-one, p-hydroxybenzyl acetone

Raspberry ketone is a natural compound that gives red raspberries their strong taste and aroma. This substance is also present in other berries, such as blackberries and cranberries. When in high doses, raspberry ketone can take fat burning effects on fat cells. These effects might be similar to ephedrin. The supplements called raspberry ketones are synthetically manufactured, as the natural Raspberry Ketone would be very expensive to produce.

Nutraceutic

  • Origin Plant Based, Synthetic
  • Source Berries, Synthetic
  • Type Ketone
  • Age Range Adults (20-59)
  • Toxicity May be toxic in high doses
  • Side effects No adverse side effects reported untill now
  • Warnings

Why be Careful

There are reports of jitteriness, tachycardia, and increased blood pressure, but there are no studies to support this.

References

  1. a b c Lopez HL, et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and womenJ Int Soc Sports Nutr. (2013)
  2. ^ Yurle S. The application of raspberry ketone to successful body careFragr J. (2003)
  3. ^ Lin CH, et al. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinaleInt J Mol Sci. (2011)
  4. ^ Tateiwa JI, et al. Cation-Exchanged Montmorillonite-Catalyzed Facile Friedel-Crafts Alkylation of Hydroxy and Methoxy Aromatics with 4-Hydroxybutan-2-one To Produce Raspberry Ketone and Some Pharmaceutically Active CompoundsJ Org Chem. (1994)
  5. ^ Beekwilder J, et al. Microbial production of natural raspberry ketoneBiotechnol J. (2007)
  6. ^ Feron G, et al. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketoneLett Appl Microbiol. (2007)
  7. a b c d Gaunt IF, et al. Acute and short-term toxicity of p-hydroxybenzyl acetone in ratsFood Cosmet Toxicol. (1970)
  8. a b c d Park KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytesPlanta Med. (2010)
  9. a b c Sporstøl S, Scheline RR. The metabolism of 4-(4-hydroxyphenyl)butan-2-one (raspberry ketone) in rats, guinea-pigs and rabbitsXenobiotica. (1982)
  10. a b Park KS. Raspberry ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytesPharm Biol. (2015)
  11. a b c d Morimoto C, et al. Anti-obese action of raspberry ketoneLife Sci. (2005)
  12. a b c d Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitisJ Med Food. (2012)
  13. ^ Ogawa Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assayBioorg Med Chem Lett. (2010)
  14. a b Harada N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humansGrowth Horm IGF Res.
  15. a b c Holst L, Haavik S, Nordeng H. Raspberry leaf–should it be recommended to pregnant womenComplement Ther Clin Pract. (2009)
  16. ^ Parsons M, Simpson M, Ponton T. Raspberry leaf and its effect on labour: safety and efficacyAust Coll Midwives Inc J. (1999)
  17. a b Parsons M, Simpson M, Wade K. Labour and the raspberry leaf herbPract Midwife. (2000)
  18. ^ Jing Zheng, et al. The effects of commercial preparations of red raspberry leaf on the contractility of the rat’s uterus in vitroReprod Sci. (2010)
  19. ^ Simpson M, et al. Raspberry leaf in pregnancy: its safety and efficacy in laborJ Midwifery Womens Health. (2001)
  20. Harada N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humansGrowth Horm IGF Res. (2008)