Pycnogenol

Pycnogenol is the registered trademark brand name of French maritime pine bark extract. It’s used as a natural supplement for several conditions, including dry skin and ADHD. Pine bark extract contains active ingredients that can also be found in peanut skin, grape seed, and witch hazel bark.

Nutraceutic

  • Origin Plant Based
  • Source Pine Bark
  • Type Bioactive Compounds

Bone and Joint Health

Bones and joints support the body and muscles, which make you move. They also take an important part in controlling vitamins, hormones and minerals, such as calcium, vitamin D and thyroid hormones. Supplements that affect bone and joint health help their structure and strength, in addition to contributing to the healthy balance of involved components.
  • Symptoms of Osteoarthritis

    Osteoarthritis is a very common chronic condition among the elderly that incompasses bones and cartilage. Symptoms include joint pain in the hands, neck, lower back, knees or hips, as well as movement difficultness.
  • Joint Pain and Stiffness

    Different types of Arthritis causes joints to be inflamed, thus they can develop stiffness, warmth, swelling, redness and pain. There are numerous of compounds that can be used to ease those symptoms

Cardiovascular Health

The cardiovascular system is responsible for blood circulation, which has the function of transporting nutrients and oxygen throughout the body. It consists of the heart and blood vessels. Cardiovascular diseases are caused by changes in the blood lipid profile, high blood pressure, diabetes, heart failure, genetic predisposition, overweight, stress, and others. The compounds that help cardiovascular health are those that normalize risk factors, such as cholesterol.
  • Heart Function

    The heart is one of the most strong muscles in the body, as it works nonstop and very steady. But it can also fail, brought down by a poor diet and lack of exercise, smoking, infection, unlucky genes, etc. It's essential to your health to take care of your heart health.

Libido and Sexual Health

Sexual health refers to sexual behavior, the health of the genitals and the signaling of sex hormones, such as testosterone, estrogen and progesterone, which are related to libido. Supplements affect various aspects of sexuality, such as hormone regulation, sexual satisfaction and can also act indirectly on fatigue, stress and vasodilation of the sexual organs.
  • Erections

    When the penis becomes rigid - erect. Erectile dysfunction may have different causes and some compounds can help by increasing blod flow or regulate a hormonal deficiency or a nutrient deficiency.
  • Age Range
  • Toxicity There is no evidence of toxicity until now
  • Side effects fatigue ,gastrointestinal issues, nausea, irritability, headache
  • Warnings Pregnancy, Autoimmune Diseases

Why be Careful

References

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  4. a b c d e f g h i j k l m n Grimm T, et al. Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteersBMC Clin Pharmacol. (2006)
  5. a b c d e f Uhlenhut K, Högger P. Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol)Free Radic Biol Med. (2012)
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  47. a b Luzzi R, et al. Pycnogenol® supplementation improves cognitive function, attention and mental performance in studentsPanminerva Med. (2011)
  48. ^ Tenenbaum S, et al. An experimental comparison of Pycnogenol and methylphenidate in adults with Attention-Deficit/Hyperactivity Disorder (ADHD)J Atten Disord. (2002)
  49. ^ Errichi S, et al. Supplementation with Pycnogenol® improves signs and symptoms of menopausal transitionPanminerva Med. (2011)
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  59. ^ Gu JQ, et al. Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophagesAm J Physiol Endocrinol Metab. (2008)
  60. ^ Gao B, et al. Pycnogenol Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells Through Regulating NF-κB-iNOS Signaling PathwayDNA Cell Biol. (2015)
  61. ^ Liu R, et al. Pycnogenol Reduces Toll-Like Receptor 4 Signaling Pathway-Mediated Atherosclerosis Formation in Apolipoprotein E-Deficient MiceJ Cardiovasc Pharmacol. (2016)
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  63. ^ Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis.
  64. a b Belcaro G, et al. Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspectsPhytother Res. (2008)
  65. a b Wilson D, et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptomsPhytother Res. (2010)
  66. ^ Choi YH, Yan GH. Pycnogenol inhibits immunoglobulin E-mediated allergic response in mast cellsPhytother Res. (2009)
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  72. ^ Maia H Jr, Haddad C, Casoy J. The effect of pycnogenol on patients with dysmenorrhea using low-dose oral contraceptivesInt J Womens Health. (2014)
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  79. a b c d Lee OH, et al. Pycnogenol® inhibits lipid accumulation in 3T3-L1 adipocytes with the modulation of reactive oxygen species (ROS) production associated with antioxidant enzyme responsesPhytother Res. (2012)
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  82. ^ Changes in lipolysis and hormone-sensitive lipase expression caused by procyanidins in 3T3-L1 adipocytes.
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  93. ^ Schäfer A, Högger P. Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidaseDiabetes Res Clin Pract. (2007)
  94. a b c Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patientsDiabetes Care. (2004)
  95. a b c d Aoki H, et al. Clinical assessment of a supplement of Pycnogenol® and L-arginine in Japanese patients with mild to moderate erectile dysfunctionPhytother Res. (2012)
  96. ^ Hosseini S, et al. Pycnogenol((R)) in the Management of AsthmaJ Med Food. (2001)
  97. ^ Belcaro G, et al. Pycnogenol® improvements in asthma managementPanminerva Med. (2011)
  98. a b Mei L, Mochizuki M, Hasegawa N. Hepatoprotective Effects of Pycnogenol in a Rat Model of Non-alcoholic SteatohepatitisPhytother Res. (2012)
  99. ^ Parveen K, et al. Protective effects of Pycnogenol on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic ratsChem Biol Interact. (2010)
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  103. a b Marini A, et al. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in womenSkin Pharmacol Physiol. (2012)