1. a b N-acetylcysteine inhibits muscle fatigue in humans.
  2. a b Witschi A, et al. The systemic availability of oral glutathioneEur J Clin Pharmacol. (1992)
  3. a b c d e Holdiness MR. Clinical pharmacokinetics of N-acetylcysteineClin Pharmacokinet. (1991)
  4. a b c d Wang L, Wang Z, Liu J. Protective effect of N-acetylcysteine on experimental chronic lead nephrotoxicity in immature female ratsHum Exp Toxicol. (2010)
  5. a b c d e Kasperczyk S, et al. The administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to leadClin Toxicol (Phila). (2013)
  6. ^ Flora G, Gupta D, Tiwari A. Toxicity of lead: A review with recent updatesInterdiscip Toxicol. (2012)
  7. a b Nehru B, Kanwar SS. Modulation by N-acetylcysteine of lead-induced alterations in rat brain: reduced glutathione levels and morphologyToxicol Mech Methods. (2007)
  8. a b Ercal N, et al. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteineFree Radic Biol Med. (1996)
  9. ^ Kasperczyk A, et al. The effect of lead-induced oxidative stress on blood viscosity and rheological properties of erythrocytes in lead exposed humansClin Hemorheol Microcirc. (2013)
  10. ^ Jung T, Bader N, Grune T. Lipofuscin: formation, distribution, and metabolic consequencesAnn N Y Acad Sci. (2007)
  11. ^ Farr SA, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 miceJ Neurochem. (2003)
  12. ^ Neuwelt EA, et al. Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat modelCancer Res. (2001)
  13. a b c d e f Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of actionJ Psychiatry Neurosci. (2011)
  14. ^ Sjödin K, et al. Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailabilityBiochem Pharmacol. (1989)
  15. a b Baker DA, et al. The origin and neuronal function of in vivo nonsynaptic glutamateJ Neurosci. (2002)
  16. a b Moran MM, et al. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seekingJ Neurosci. (2005)
  17. ^ Kau KS, et al. Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seekingNeuroscience. (2008)
  18. ^ Madayag A, et al. Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaineJ Neurosci. (2007)
  19. ^ Xi ZX, et al. Modulation of group II metabotropic glutamate receptor signaling by chronic cocaineJ Pharmacol Exp Ther. (2002)
  20. a b c d Schmaal L, et al. N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy studyNeuropsychopharmacology. (2012)
  21. a b Varga V, et al. Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptorsNeurochem Res. (1997)
  22. ^ Ogita K, et al. Glutathione-induced inhibition of Na+-independent and -dependent bindings of L-{3H}glutamate in rat brainLife Sci. (1986)
  23. ^ Gere-Pászti E, Jakus J. The effect of N-acetylcysteine on amphetamine-mediated dopamine release in rat brain striatal slices by ion-pair reversed-phase high performance liquid chromatographyBiomed Chromatogr. (2009)
  24. ^ Janáky R, et al. Modulation of {3H}dopamine release by glutathione in mouse striatal slicesNeurochem Res. (2007)
  25. ^ Hashimoto K, et al. Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamineAnn N Y Acad Sci. (2004)
  26. ^ Berk M, et al. Nail-biting stuff? The effect of N-acetyl cysteine on nail-bitingCNS Spectr. (2009)
  27. ^ Grant JE, et al. Skin picking disorderAm J Psychiatry. (2012)
  28. a b Ghanizadeh A, Moghimi-Sarani E. A randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disordersBMC Psychiatry. (2013)
  29. a b c Hardan AY, et al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autismBiol Psychiatry. (2012)
  30. ^ Koob GF, Volkow ND. Neurocircuitry of addictionNeuropsychopharmacology. (2010)
  31. ^ Huey ED, et al. A psychological and neuroanatomical model of obsessive-compulsive disorderJ Neuropsychiatry Clin Neurosci. (2008)
  32. a b Chakraborty S, et al. Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive-compulsive disorderProg Neuropsychopharmacol Biol Psychiatry. (2009)
  33. ^ Kuloglu M, et al. Antioxidant enzyme activities and malondialdehyde levels in patients with obsessive-compulsive disorderNeuropsychobiology. (2002)
  34. ^ Ersan S, et al. Examination of free radical metabolism and antioxidant defence system elements in patients with obsessive-compulsive disorderProg Neuropsychopharmacol Biol Psychiatry. (2006)
  35. a b Ozdemir E, et al. Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorderProg Neuropsychopharmacol Biol Psychiatry. (2009)
  36. a b Egashira N, et al. N-acetyl-L-cysteine inhibits marble-burying behavior in miceJ Pharmacol Sci. (2012)
  37. ^ Bloch MH, et al. Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorderMol Psychiatry. (2010)
  38. ^ Lafleur DL, et al. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorderPsychopharmacology (Berl). (2006)
  39. ^ Afshar H, et al. N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trialJ Clin Psychopharmacol. (2012)
  40. ^ Dell’Osso B, et al. Epidemiologic and clinical updates on impulse control disorders: a critical reviewEur Arch Psychiatry Clin Neurosci. (2006)
  41. ^ Grant JE, Odlaug BL, Potenza MN. Addicted to hair pulling? How an alternate model of trichotillomania may improve treatment outcomeHarv Rev Psychiatry. (2007)
  42. ^ Odlaug BL, Grant JE. N-acetyl cysteine in the treatment of grooming disordersJ Clin Psychopharmacol. (2007)
  43. ^ Grant JE, Odlaug BL, Kim SW. N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled studyArch Gen Psychiatry. (2009)
  44. ^ Heishman SJ, Singleton EG. Assessment of cannabis craving using the Marijuana Craving QuestionnaireMethods Mol Med. (2006)
  45. a b Gray KM, et al. N-acetylcysteine (NAC) in young marijuana users: an open-label pilot studyAm J Addict. (2010)
  46. ^ Kampman KM, et al. Reliability and validity of the Cocaine Selective Severity AssessmentAddict Behav. (1998)
  47. ^ LaRowe SD, et al. Safety and tolerability of N-acetylcysteine in cocaine-dependent individualsAm J Addict. (2006)
  48. a b Knackstedt LA, et al. The role of cystine-glutamate exchange in nicotine dependence in rats and humansBiol Psychiatry. (2009)
  49. ^ Cobley JN, et al. N-Acetylcysteine Attenuates Fatigue Following Repeated-Bouts of Intermittent Exercise: Practical Implications for Tournament SituationsInt J Sport Nutr Exerc Metab. (2011)
  50. a b Cobley JN, et al. N-Acetylcysteine’s attenuation of fatigue after repeated bouts of intermittent exercise: practical implications for tournament situationsInt J Sport Nutr Exerc Metab. (2011)
  51. ^ Dringen R, Hirrlinger J. Glutathione pathways in the brainBiol Chem. (2003)
  52. ^ Giordano G, White CC, Costa LG. Assessment of glutathione homeostasisMethods Mol Biol. (2011)
  53. a b Benrahmoune M, Thérond P, Abedinzadeh Z. The reaction of superoxide radical with N-acetylcysteineFree Radic Biol Med. (2000)
  54. ^ Bielski BH, Shiue GG. Reaction rates of superoxide radicals with the essential amino acidsCiba Found Symp. (1978)
  55. ^ Winterbourn CC, Metodiewa D. The reaction of superoxide with reduced glutathioneArch Biochem Biophys. (1994)
  56. ^ Cardey B, Foley S, Enescu M. Mechanism of thiol oxidation by the superoxide radicalJ Phys Chem A. (2007)
  57. ^ Moldéus P, Cotgreave IA, Berggren M. Lung protection by a thiol-containing antioxidant: N-acetylcysteineRespiration. (1986)
  58. a b Aruoma OI, et al. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acidFree Radic Biol Med. (1989)
  59. ^ Heinecke JW. Pathways for oxidation of low density lipoprotein by myeloperoxidase: tyrosyl radical, reactive aldehydes, hypochlorous acid and molecular chlorineBiofactors. (1997)
  60. a b c van Overveld FJ, et al. New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteineJ Physiol Pharmacol. (2005)
  61. ^ Karbasi A, et al. Effect of oral N-acetyl cysteine on eradication of Helicobacter pylori in patients with dyspepsiaMinerva Gastroenterol Dietol. (2013)
  62. ^ Scalley RD, Conner CS. Acetaminophen poisoning: a case report of the use of acetylcysteineAm J Hosp Pharm. (1978)
  63. a b c d e Tsikas D1, et al. N-Acetylcysteine (NAC) inhibits renal nitrite and nitrate reabsorption in healthy subjects and in patients undergoing cardiac surgery: risk of nitric oxide (NO) bioavailability loss by NACInt J Cardiol. (2014)
  64. ^ Chai YC1, et al. Identification of an abundant S-thiolated rat liver protein as carbonic anhydrase III; characterization of S-thiolation and dethiolation reactionsArch Biochem Biophys. (1991)
  65. ^ Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors.
  66. a b Sütö T1, et al. Acute changes in urinary excretion of nitrite + nitrate do not necessarily predict renal vascular NO productionKidney Int. (1995)
  67. a b Chobanyan-Jürgens K1, et al. Renal carbonic anhydrases are involved in the reabsorption of endogenous nitriteNitric Oxide. (2012)
  68. ^ Aamand R1, et al. Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilationAm J Physiol Heart Circ Physiol. (2009)
  69. ^ Torring MS1, et al. The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibitionInvest Ophthalmol Vis Sci. (2009)
  70. a b c d Palmer LA1, et al. S-nitrosothiols signal hypoxia-mimetic vascular pathologyJ Clin Invest. (2007)
  71. ^ Hildebrandt W1, et al. Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O(2) chemosensitivityBlood. (2002)
  72. ^ McMahon TJ1, et al. A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertensionProc Natl Acad Sci U S A. (2005)
  73. ^ Gaston B1, et al. S-nitrosothiol signaling in respiratory biologyAm J Respir Crit Care Med. (2006)
  74. ^ Lonergan KM1, et al. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2Mol Cell Biol. (1998)
  75. ^ Ohh M1, et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau proteinNat Cell Biol. (2000)
  76. a b van Overveld FJ, Vermeire PA, De Backer WA. Induced sputum of patients with chronic obstructive pulmonary disease (COPD) contains adhesion-promoting, therapy-sensitive factorsInflamm Res. (2000)
  77. a b Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidantsJ Drugs Dermatol. (2012)
  78. ^ Sahib A, et al. Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular AcneJ Clin Exp Dermatol Res. (2012)
  79. ^ Celli BR, MacNee W; ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paperEur Respir J. (2004)
  80. ^ Vernooy JH, et al. Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputumAm J Respir Crit Care Med. (2002)
  81. ^ Sadowska AM, et al. The interrelationship between markers of inflammation and oxidative stress in chronic obstructive pulmonary disease: modulation by inhaled steroids and antioxidantRespir Med. (2005)
  82. ^ Sadowska AM, Manuel-Y-Keenoy B, De Backer WA. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a reviewPulm Pharmacol Ther. (2007)
  83. a b De Benedetto F, et al. Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPDPulm Pharmacol Ther. (2005)
  84. ^ Kostikas K, et al. Oxidative stress in expired breath condensate of patients with COPDChest. (2003)
  85. ^ De Benedetto F, et al. Validation of a new technique to assess exhaled hydrogen peroxide: results from normals and COPD patientsMonaldi Arch Chest Dis. (2000)
  86. a b Decramer M, et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trialLancet. (2005)
  87. ^ Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease.
  88. ^ Melnyk S, et al. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autismJ Autism Dev Disord. (2012)
  89. ^ Parellada M, et al. Plasma antioxidant capacity is reduced in Asperger syndromeJ Psychiatr Res. (2012)
  90. ^ Essa MM, et al. Increased markers of oxidative stress in autistic children of the Sultanate of OmanBiol Trace Elem Res. (2012)
  91. ^ Ming X, et al. Increased excretion of a lipid peroxidation biomarker in autismProstaglandins Leukot Essent Fatty Acids. (2005)
  92. ^ Chauhan A, Audhya T, Chauhan V. Brain region-specific glutathione redox imbalance in autismNeurochem Res. (2012)
  93. ^ Bowers K, et al. Glutathione pathway gene variation and risk of autism spectrum disordersJ Neurodev Disord. (2011)
  94. ^ Al-Yafee YA, et al. Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi ArabiaBMC Neurol. (2011)
  95. ^ Ghanizadeh A. Could fever and neuroinflammation play a role in the neurobiology of autism? A subject worthy of more researchInt J Hyperthermia. (2011)
  96. ^ Harrison C. Neurodevelopmental disorders: Glutamate blockers show benefit in models of autism spectrum disordersNat Rev Drug Discov. (2012)
  97. ^ Niederhofer H. Glutamate antagonists seem to be slightly effective in psychopharmacologic treatment of autismJ Clin Psychopharmacol. (2007)
  98. ^ Ghanizadeh A, Derakhshan N. N-acetylcysteine for treatment of autism, a case reportJ Res Med Sci. (2012)
  99. ^ Aman MG, et al. The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effectsAm J Ment Defic. (1985)
  100. ^ Walters MT, et al. A double-blind, cross-over, study of oral N-acetylcysteine in Sjögren’s syndromeScand J Rheumatol Suppl. (1986)
  101. ^ Ekins BR, et al. The effect of activated charcoal on N-acetylcysteine absorption in normal subjectsAm J Emerg Med. (1987)
  102. ^ Renzi FP, et al. Concomitant use of activated charcoal and N-acetylcysteineAnn Emerg Med. (1985)
  103. a b c Wang AL1, et al. A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in miceHepatol Res. (2006)
  104. ^ Ozaras R1, et al. N-acetylcysteine attenuates alcohol-induced oxidative stress in the ratWorld J Gastroenterol. (2003)
  105. a b c Caro AA1, et al. N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronicallyAlcohol Clin Exp Res. (2014)
  106. ^ Aydin S1, et al. N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissueTohoku J Exp Med. (2002)
  107. ^ Ferreira Seiva FR1, et al. Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in ratsAlcohol. (2009)