Lion’s Mane

Lion's Mane, Yamabushitake, Bear's head mushroom

The lion's mane mushroom is often called a "natural nutrient for neurons" because of its impressive ability to stimulate the production of nerve growth factor (NGF). Although NGF is widely associated with its significance for neurological function, it is also effective in many other areas, including our immunity. Our immune cells express receptors for NGF, which allows for immunoregulation when we have a supply of NGF.


  • Origin Funghi
  • Source Itself
  • Type Bioactive polysaccharides, Bioactive proteins, Minerals, Vitamins, Nootropic
  • Age Range Teenagers (13-19), Adults (20-59), Seniors (>60)
  • Toxicity May be toxic in high doses
  • Side effects Difficulty Breathing, Skin Rashes
  • Warnings Allergies, Diabetes Medication, Pregnancy

Why be Careful


  1. ^ Tanaka A, Matsuda H. Expression of nerve growth factor in itchy skins of atopic NC/NgaTnd miceJ Vet Med Sci. (2005)
  2. a b c d e Mori K, et al. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cellsBiol Pharm Bull. (2008)
  3. a b Wong KH, et al. Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review)Int J Med Mushrooms. (2012)
  4. ^ Bioactive Substances in YAMABUSHITAKE, the Hericium erinaceum Fungus, and its Medicinal Utilization.
  5. ^ Yaoita Y, Danbara K, Kikuchi M. Two new aromatic compounds from Hericium erinaceum (BULL.: FR.) PERS(1)Chem Pharm Bull (Tokyo). (2005)
  6. ^ Chromans, hericenones F, G and H from the mushroom Hericium erinaceum.
  7. a b Ueda K, et al. An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceumBioorg Med Chem. (2008)
  8. ^ Erinacines J and K from the mycelia of Hericium erinaceum.
  9. ^ Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum.
  10. ^ Antimicrobial chlorinated orcinol derivatives from mycelia of Hericium erinaceum.
  11. ^ A sialic acid-binding lectin from the mushroom Hericium erinaceum.
  12. ^ Li JL, et al. A comparative study on sterols of ethanol extract and water extract from Hericium erinaceusZhongguo Zhong Yao Za Zhi. (2001)
  13. ^ Mizuno T, et al. Antitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtouBiosci Biotechnol Biochem. (1992)
  14. ^ Xu H, et al. Chemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activitiesInt J Biol Macromol. (2010)
  15. a b c Lee JS, et al. Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceusJ Microbiol Biotechnol. (2009)
  16. ^ Dong Q, Jia LM, Fang JN. A beta-D-glucan isolated from the fruiting bodies of Hericium erinaceus and its aqueous conformationCarbohydr Res. (2006)
  17. a b Han ZH, Ye JM, Wang GF. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharidesInt J Biol Macromol. (2013)
  18. a b c Abdullah N, et al. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory ActivitiesEvid Based Complement Alternat Med. (2012)
  19. ^ Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus ( Bull .: Fr .) Pers . Extracts.
  20. ^ Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum.
  21. a b Neurotropic and Trophic Action of Lion’s Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) Extracts on Nerve Cells in Vitro.
  22. ^ Ueda K, et al. Endoplasmic reticulum (ER) stress-suppressive compounds from scrap cultivation beds of the mushroom Hericium erinaceumBiosci Biotechnol Biochem. (2009)
  23. ^ Kolotushkina EV, et al. The influence of Hericium erinaceus extract on myelination process in vitroFiziol Zh. (2003)
  24. ^ Mori K, et al. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in miceBiomed Res. (2011)
  25. a b Mori K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trialPhytother Res. (2009)
  26. a b Nagano M, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intakeBiomed Res. (2010)
  27. a b Wong KH, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)Evid Based Complement Alternat Med. (2011)
  28. ^ Activity of Aqueous Extracts of Lion’s Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) on the Neural Cell Line NG108-15.
  29. ^ Farndale RW, et al. The role of collagen in thrombosis and hemostasisJ Thromb Haemost. (2004)
  30. a b Mori K, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregationPhytomedicine. (2010)
  31. ^ Angiotensin I-converting enzyme inhibitor from Grifola frondosa.
  32. a b Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum.
  33. ^ Hagiwara SY, et al. A phytochemical in the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hypertensive ratsBiosci Biotechnol Biochem. (2005)
  34. ^ Inhibitory effects of l-pipecolic acid from the edible mushroom, Sarcodon aspratus, on angiotensin I-converting enzyme.
  35. ^ Antioxidative and ACE inhibitory activities in enzymatic hydrolysates of the cotton leafworm, Spodoptera littoralis.
  36. a b c d e Hiwatashi K, et al. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat dietBiosci Biotechnol Biochem. (2010)
  37. a b Yang BK, Park JB, Song CH. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceusBiosci Biotechnol Biochem. (2003)
  38. ^ Kim YO, et al. Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophagesImmunopharmacol Immunotoxicol. (2011)
  39. ^ Wang JC, et al. Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium sppKaohsiung J Med Sci. (2001)
  40. a b Abdulla MA, et al. Potential activity of aqueous extract of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in ratsInt J Med Mushrooms. (2011)
  41. a b Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted miceJ Agric Food Chem. (2013)
  42. ^ Park ID, et al. Toxicological study on MUNOPHIL, water extract of Panax ginseng and Hericium erinaceum in ratsJ Acupunct Meridian Stud. (2008)
  43. ^ Nakatsugawa M, et al. Hericium erinaceum (yamabushitake) extract-induced acute respiratory distress syndrome monitored by serum surfactant proteinsIntern Med. (2003)
  44. ^ A method for estimating the probability of adverse drug reactions.