1. a b c d Sun J. D-Limonene: safety and clinical applicationsAltern Med Rev. (2007)
  2. ^ Perez-Cacho PR, Rouseff RL. Fresh squeezed orange juice odor: a reviewCrit Rev Food Sci Nutr. (2008)
  3. ^ Limem-Ben Amor I, et al. Phytochemistry and biological activities of Phlomis speciesJ Ethnopharmacol. (2009)
  4. ^ Acharya A, et al. Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesisRecent Pat Food Nutr Agric. (2010)
  5. ^ Satomi Y, et al. Production of the monoterpene limonene and modulation of apoptosis-related proteins in embryonic-mouse NIH 3T3 fibroblast cells by introduction of the limonene synthase gene isolated from Japanese catnip (Schizonepeta tenuifolia)Biotechnol Appl Biochem. (2009)
  6. ^ Hyatt DC, et al. Structure of limonene synthase, a simple model for terpenoid cyclase catalysisProc Natl Acad Sci U S A. (2007)
  7. ^ Crowell PL, et al. Human metabolism of the experimental cancer therapeutic agent d-limoneneCancer Chemother Pharmacol. (1994)
  8. ^ Miyazawa M, Shindo M, Shimada T. Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomesDrug Metab Dispos. (2002)
  9. ^ Shimada T, Shindo M, Miyazawa M. Species differences in the metabolism of (+)- and (-)-limonenes and their metabolites, carveols and carvones, by cytochrome P450 enzymes in liver microsomes of mice, rats, guinea pigs, rabbits, dogs, monkeys, and humansDrug Metab Pharmacokinet. (2002)
  10. ^ Kodama R, et al. Studies on the metabolism of d-limonene (p-mentha-1,8-diene). IV. Isolation and characterization of new metabolites and species differences in metabolismXenobiotica. (1976)
  11. a b Vigushin DM, et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials CommitteeCancer Chemother Pharmacol. (1998)
  12. ^ Crowell PL, et al. Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growthCancer Chemother Pharmacol. (1992)
  13. a b c Pharmacokinetics of Perillic Acid in Humans after a Single Dose Administration of a Citrus Preparation Rich in d-Limonene Content.
  14. ^ Assessing Dietary D-Limonene Intake for Epidemiological Studies.
  15. ^ Dietary d-limonene alleviates insulin resistance and oxidative stress-induced liver injury in high-fat diet and L-NAME-treated rats.
  16. ^ Miller JA, et al. Adipose tissue accumulation of d-limonene with the consumption of a lemonade preparation rich in d-limonene contentNutr Cancer. (2010)
  17. ^ Miller JA, et al. Determination of d-limonene in adipose tissue by gas chromatography-mass spectrometryJ Chromatogr B Analyt Technol Biomed Life Sci. (2008)
  18. ^ Metz SA, et al. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteinsBiochem J. (1993)
  19. ^ Park HM, et al. Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A(2A) receptorsBiochem Biophys Res Commun. (2011)
  20. ^ Crowell PL. Monoterpenes in breast cancer chemopreventionBreast Cancer Res Treat. (1997)
  21. ^ Crowell PL. Prevention and therapy of cancer by dietary monoterpenesJ Nutr. (1999)
  22. ^ Tsuda H, et al. Cancer prevention by natural compoundsDrug Metab Pharmacokinet. (2004)
  23. ^ Gelb MH, et al. The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcoholCancer Lett. (1995)
  24. ^ Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes.
  25. ^ Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes.
  26. ^ Flamm WG, Lehman-McKeeman LD. The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessmentRegul Toxicol Pharmacol. (1991)