Huperzine A

Huperzine A, Huperzia Serrata

Huperzine A is used to improve memory and mental function in people with Alzheimer disease or other types of dementia. Huperzine A increases levels of a chemical called acetylcholine. This seems to help in diseases that interfere with memory and thinking (dementia), and in the muscle disease, myasthenia gravis.


  • Origin Plant Based, Synthetic
  • Source Chinese club moss
  • Type Phytochemicals, Flavonoids, Nootropic
  • Age Range Teenagers (13-19), Adults (20-59), Seniors (>60)
  • Toxicity May be toxic in high doses
  • Side effects Nausea, Diarrhea, Vomiting, Dry Mouth, Constipation, Sweating, Blurred Vision, Fainting, Restlessness, Loss of Appetite, Cramps, High Blood Pressure, Dizziness
  • Warnings Pregnancy, Breastfeeding, Low Blood Pressure, Epilepsy, GI Tract Blockage, Gastric Ulcers, COPD, Alzheimer's Disease

Why be Careful


  1. ^ Howes MJ, Perry NS, Houghton PJ. Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disordersPhytother Res. (2003)
  2. a b c Ha GT, Wong RK, Zhang Y. Huperzine a as potential treatment of Alzheimer’s disease: an assessment on chemistry, pharmacology, and clinical studiesChem Biodivers. (2011)
  3. ^ Ma X, Gang DR. In vitro production of huperzine A, a promising drug candidate for Alzheimer’s diseasePhytochemistry. (2008)
  4. ^ Total Synthesis of (−)-Huperzine A.
  5. a b Wang XD, et al. Comparison of the effects of cholinesterase inhibitors on {3H}MK-801 binding in rat cerebral cortexNeurosci Lett. (1999)
  6. ^ Rajendran V, et al. Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine BBioorg Med Chem Lett. (2002)
  7. ^ Zhang HY, Tang XC. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cellsNeurosci Lett. (2000)
  8. ^ Feng S, et al. Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitorsJ Med Chem. (2005)
  9. ^ He XC, et al. Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine BBioorg Med Chem. (2007)
  10. a b c Qian BC, et al. Pharmacokinetics of tablet huperzine A in six volunteersZhongguo Yao Li Xue Bao. (1995)
  11. a b Li YX, et al. Pharmacokinetics of huperzine A following oral administration to human volunteersEur J Drug Metab Pharmacokinet. (2007)
  12. a b Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
  13. a b Chemistry, Pharmacology, and Clinical Efficacy of the Chinese Nootropic Agent Huperzine A.
  14. ^ Development of huperzine A and B for treatment of Alzheimer’s disease.
  15. ^ Boudinot E, et al. Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterasePharmacol Biochem Behav. (2005)
  16. ^ Lane RM, Potkin SG, Enz A. Targeting acetylcholinesterase and butyrylcholinesterase in dementiaInt J Neuropsychopharmacol. (2006)
  17. ^ Ved HS, et al. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamateNeuroreport. (1997)
  18. ^ Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
  19. ^ Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
  20. ^ The NMDA receptor ion channel: a site for binding of Huperzine A.
  21. a b Ma T, et al. Huperzine A promotes hippocampal neurogenesis in vitro and in vivoBrain Res. (2013)