1. a b Vitamin D status affects strength gains in older adults supplemented with a combination of β-hydroxy-β-methylbutyrate, arginine, and lysine: a cohort study.
  2. a b c Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine.
  3. a b c Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women.
  4. ^ Effects of amino acids supplement on physiological adaptations to resistance training.
  5. a b c Sabourin PJ, Bieber LL. Formation of beta-hydroxyisovalerate by an alpha-ketoisocaproate oxygenase in human liverMetabolism. (1983)
  6. a b c d Van Koevering M, Nissen S. Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivoAm J Physiol. (1992)
  7. a b c Nissen S, et al. Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise trainingJ Appl Physiol. (1996)
  8. ^ Calcium β-Hydroxy-β-Methylbutyrate.
  9. ^ Vukovich MD, et al. beta-hydroxy-beta-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humansJ Nutr Biochem. (2001)
  10. a b c d Fuller JC Jr, et al. Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB saltBr J Nutr. (2011)
  11. ^ Gallagher PM, et al. Beta-hydroxy-beta-methylbutyrate ingestion, Part I: effects on strength and fat free massMed Sci Sports Exerc. (2000)
  12. ^ Wilson JM, et al. Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in ratsJ Int Soc Sports Nutr. (2012)
  13. ^ Kim JS, et al. β-hydroxy-β-methylbutyrate did not enhance high intensity resistance training-induced improvements in myofiber dimensions and myogenic capacity in aged female ratsMol Cells. (2012)
  14. a b Vukovich MD, Stubbs NB, Bohlken RM. Body composition in 70-year-old adults responds to dietary beta-hydroxy-beta-methylbutyrate similarly to that of young adultsJ Nutr. (2001)
  15. a b c d e f g h i Kornasio R, et al. Beta-hydroxy-beta-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathwaysBiochim Biophys Acta. (2009)
  16. ^ Peterson AL, et al. In vitro exposure with beta-hydroxy-beta-methylbutyrate enhances chicken macrophage growth and functionVet Immunol Immunopathol. (1999)
  17. ^ Siwicki AK, et al. In vitro effects of beta-hydroxy-beta-methylbutyrate (HMB) on cell-mediated immunity in fishVet Immunol Immunopathol. (2000)
  18. ^ The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways.
  19. ^ Elia D, et al. Sonic hedgehog promotes proliferation and differentiation of adult muscle cells: Involvement of MAPK/ERK and PI3K/Akt pathwaysBiochim Biophys Acta. (2007)
  20. a b c d Pimentel GD, et al. β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathwayNutr Metab (Lond). (2011)
  21. a b c d Eley HL, Russell ST, Tisdale MJ. Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrateAm J Physiol Endocrinol Metab. (2008)
  22. ^ Krajnak K, et al. Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old ratsMuscle Nerve. (2006)
  23. ^ Jejurikar SS, et al. Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosisExp Gerontol. (2006)
  24. ^ Tews DS, Goebel HH. DNA-fragmentation and expression of apoptosis-related proteins in muscular dystrophiesNeuropathol Appl Neurobiol. (1997)
  25. ^ Tidball JG, et al. Apoptosis precedes necrosis of dystrophin-deficient muscleJ Cell Sci. (1995)
  26. a b c d Eley HL, et al. Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuliAm J Physiol Endocrinol Metab. (2007)
  27. a b Aversa Z, et al. β-hydroxy-β-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexiaInt J Oncol. (2011)
  28. ^ Pugazhenthi S, et al. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding proteinJ Biol Chem. (2000)
  29. ^ Green DR. Apoptotic pathways: ten minutes to deadCell. (2005)
  30. ^ Pinheiro CH, et al. Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscleEur J Appl Physiol. (2012)
  31. a b c Wilson JM, et al. Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damageNutr Metab (Lond). (2009)
  32. a b c Wilson JM, et al. β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained menBr J Nutr. (2013)
  34. a b c d Thomson JS, Watson PE, Rowlands DS. Effects of nine weeks of beta-hydroxy-beta- methylbutyrate supplementation on strength and body composition in resistance trained menJ Strength Cond Res. (2009)
  35. a b Hoffman JR, et al. Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity trainingJ Strength Cond Res. (2004)
  36. ^ Ransone J, et al. The effect of beta-hydroxy beta-methylbutyrate on muscular strength and body composition in collegiate football playersJ Strength Cond Res. (2003)
  37. ^ Paddon-Jones D, Keech A, Jenkins D. Short-term beta-hydroxy-beta-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damageInt J Sport Nutr Exerc Metab. (2001)
  38. ^ van Someren KA, Edwards AJ, Howatson G. Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in manInt J Sport Nutr Exerc Metab. (2005)
  39. ^ Nunan D, Howatson G, van Someren KA. Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementationJ Strength Cond Res. (2010)
  40. ^ Abumrad NN, Rathmacher JA. Exercise-Induced Muscle Damage is Not Attenuated by Maximuscle β-Hydroxy-β-Methylbutyrate-1000™ SupplementationJ Strength Cond Res. (2011)
  41. a b c Wilkinson DJ, et al. Effects of Leucine and its metabolite, β-hydroxy-β-methylbutyrate (HMB) on human skeletal muscle protein metabolismJ Physiol. (2013)
  42. ^ Panton LB, et al. Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (hmb) during resistance trainingNutrition. (2000)
  43. a b c d e f Portal S, et al. The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled studyEur J Appl Physiol. (2011)
  44. a b c Slater G, et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained menInt J Sport Nutr Exerc Metab. (2001)
  45. a b c Kreider RB, et al. Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strengthInt J Sports Med. (1999)
  46. ^ Lamboley CR, Royer D, Dionne IJ. Effects of beta-hydroxy-beta-methylbutyrate on aerobic-performance components and body composition in college studentsInt J Sport Nutr Exerc Metab. (2007)
  47. a b Zanchi NE, Nicastro H, Lancha AH Jr. Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studiesNutr Metab (Lond). (2008)
  48. ^ Dardevet D, et al. Stimulation of in vitro rat muscle protein synthesis by leucine decreases with ageJ Nutr. (2000)
  49. ^ Filho JC, et al. Simultaneous measurements of free amino acid patterns of plasma, muscle and erythrocytes in healthy human subjectsClin Nutr. (1997)
  50. ^ Bohé J, et al. Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response studyJ Physiol. (2003)
  51. ^ Tischler ME, Desautels M, Goldberg AL. Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscleJ Biol Chem. (1982)
  52. ^ Buse MG, Weigand DA. Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic ratsBiochim Biophys Acta. (1977)
  53. a b c Aversa Z, et al. β-Hydroxy-β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophyBiochem Biophys Res Commun. (2012)
  54. ^ Jiang Y, et al. Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiationJ Cell Physiol. (2013)
  55. a b Russell ST, Tisdale MJ. Mechanism of attenuation by beta-hydroxy-beta-methylbutyrate of muscle protein degradation induced by lipopolysaccharideMol Cell Biochem. (2009)
  56. a b Eley HL, Russell ST, Tisdale MJ. Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrateAm J Physiol Endocrinol Metab. (2008)
  57. ^ Deutz NE, et al. Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adultsClin Nutr. (2013)
  58. ^ Stein TP, et al. Attenuation of the protein wasting associated with bed rest by branched-chain amino acidsNutrition. (1999)
  59. ^ Stein TP, et al. Branched-chain amino acid supplementation during bed rest: effect on recoveryJ Appl Physiol. (2003)
  60. ^ May PE, et al. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamineAm J Surg. (2002)
  61. ^ Smith HJ, Mukerji P, Tisdale MJ. Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle lossCancer Res. (2005)
  62. ^ Clark RH, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled studyJPEN J Parenter Enteral Nutr. (2000)
  64. ^ Jówko E, et al. Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training programNutrition. (2001)
  65. ^ O’Connor DM, Crowe MJ. Effects of six weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on strength, power, and anthropometry of highly trained athletesJ Strength Cond Res. (2007)
  66. ^ O’Connor DM, Crowe MJ. Effects of beta-hydroxy-beta-methylbutyrate and creatine monohydrate supplementation on the aerobic and anaerobic capacity of highly trained athletesJ Sports Med Phys Fitness. (2003)
  67. ^ Baxter JH, et al. Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB)Food Chem Toxicol. (2005)
  68. ^ Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers.
  69. ^ International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB).
  70. ^ Gallagher PM, et al. Beta-hydroxy-beta-methylbutyrate ingestion, part II: effects on hematology, hepatic and renal functionMed Sci Sports Exerc. (2000)
  71. ^ Nissen S, et al. beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factorsJ Nutr. (2000)
  72. ^ Rathmacher JA, et al. Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parametersJPEN J Parenter Enteral Nutr. (2004)