1. ^ Chemistry and biological activities of C. longa.
  2. a b Kiuchi F, et al. Nematocidal activity of turmeric: synergistic action of curcuminoidsChem Pharm Bull (Tokyo). (1993)
  3. ^ Changtam C, et al. Curcuminoid analogs with potent activity against Trypanosoma and Leishmania speciesEur J Med Chem. (2010)
  4. a b Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species.
  5. ^ Chang CJ, et al. Beneficial impact of Zingiber zerumbet on insulin sensitivity in fructose-fed ratsPlanta Med. (2012)
  6. a b Zhou H, Beevers CS, Huang S. The targets of curcuminCurr Drug Targets. (2011)
  7. ^ Usharani P, et al. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week studyDrugs R D. (2008)
  8. ^ Venkataranganna MV, et al. NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOSWorld J Gastroenterol. (2007)
  9. a b Esatbeyoglu T, et al. Curcumin-from molecule to biological functionAngew Chem Int Ed Engl. (2012)
  10. ^ Scotter MJ. Methods for the determination of European Union-permitted added natural colours in foods: a reviewFood Addit Contam Part A Chem Anal Control Expo Risk Assess. (2011)
  11. a b Wang YJ, et al. Stability of curcumin in buffer solutions and characterization of its degradation productsJ Pharm Biomed Anal. (1997)
  12. ^ Sharma RA, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancerClin Cancer Res. (2001)
  13. a b c Lao CD, et al. Dose escalation of a curcuminoid formulationBMC Complement Altern Med. (2006)
  14. a b c d e Cheng AL, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesionsAnticancer Res. (2001)
  15. a b Dhillon N, et al. Phase II trial of curcumin in patients with advanced pancreatic cancerClin Cancer Res. (2008)
  16. ^ Jamwal R. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteersJ Integr Med. (2018)
  17. a b Shoba G, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteersPlanta Med. (1998)
  18. ^ Marczylo TH, et al. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholineCancer Chemother Pharmacol. (2007)
  19. a b Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical researchAltern Med Rev. (2009)
  20. a b Cuomo J, et al. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulationJ Nat Prod. (2011)
  21. a b Sasaki H, et al. Innovative preparation of curcumin for improved oral bioavailabilityBiol Pharm Bull. (2011)
  22. ^ Zhongfa L, et al. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in miceCancer Chemother Pharmacol. (2012)
  23. a b Kanai M, et al. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteersCancer Chemother Pharmacol. (2012)
  24. a b Karin M, Liu Z, Zandi E. AP-1 function and regulationCurr Opin Cell Biol. (1997)
  25. ^ Angel P, et al. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factorCell. (1987)
  26. ^ Dhandapani KM, Mahesh VB, Brann DW. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factorsJ Neurochem. (2007)
  27. ^ Bierhaus A, et al. The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa BThromb Haemost. (1997)
  28. ^ Dickinson DA, et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expressionFASEB J. (2003)
  29. ^ Beevers CS, et al. Curcumin disrupts the Mammalian target of rapamycin-raptor complexCancer Res. (2009)
  30. ^ Yu S, et al. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanismMol Cancer Ther. (2008)
  31. ^ Takeuchi T, et al. Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambdaGenes Cells. (2006)
  32. a b Leu TH, et al. Direct inhibitory effect of curcumin on Src and focal adhesion kinase activityBiochem Pharmacol. (2003)
  33. ^ Lee CW, et al. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylationJ Cell Physiol. (2006)
  34. ^ Fang J, Lu J, Holmgren A. Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activityJ Biol Chem. (2005)
  35. ^ Skrzypczak-Jankun E, et al. Structure of curcumin in complex with lipoxygenase and its significance in cancerInt J Mol Med. (2003)
  36. ^ Gupta KK, et al. Dietary antioxidant curcumin inhibits microtubule assembly through tubulin bindingFEBS J. (2006)
  37. a b c Hu GX, et al. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3Bioorg Med Chem Lett. (2010)
  38. a b Liao S, et al. Growth suppression of hamster flank organs by topical application of catechins, alizarin, curcumin, and myristoleic acidArch Dermatol Res. (2001)
  39. ^ Bustanji Y, et al. Inhibition of glycogen synthase kinase by curcumin: Investigation by simulated molecular docking and subsequent in vitro/in vivo evaluationJ Enzyme Inhib Med Chem. (2009)
  40. ^ Shin HK, et al. Inhibitory effect of curcumin on motility of human oral squamous carcinoma YD-10B cells via suppression of ERK and NF-kappaB activationsPhytother Res. (2010)
  41. a b Wang Z, et al. Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cellsCancer. (2006)
  42. ^ Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factorsOncogene. (1999)
  43. ^ Aggarwal S, et al. Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signalingInt J Cancer. (2004)
  44. a b Sung B, et al. Cancer cell signaling pathways targeted by spice-derived nutraceuticalsNutr Cancer. (2012)
  45. ^ Anand P1, et al. Bioavailability of curcumin: problems and promisesMol Pharm. (2007)
  46. a b Comparative absorption of curcumin formulations.
  47. ^ Yallapu MM1, Jaggi M, Chauhan SC. Curcumin nanoformulations: a future nanomedicine for cancerDrug Discov Today. (2012)
  48. ^ Liu A1, et al. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcuminJ Pharm Biomed Anal. (2006)
  49. ^ Yu H1, Huang Q. Improving the oral bioavailability of curcumin using novel organogel-based nanoemulsionsJ Agric Food Chem. (2012)
  50. ^ Hu L1, et al. Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicleJ Agric Food Chem. (2012)
  51. ^ Khalil NM1, et al. Pharmacokinetics of curcumin-loaded PLGA and PLGA-PEG blend nanoparticles after oral administration in ratsColloids Surf B Biointerfaces. (2013)
  52. ^ Antony B1, et al. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of CurcuminIndian J Pharm Sci. (2008)
  53. ^ Kulkarni SK1, Akula KK, Deshpande J. Evaluation of antidepressant-like activity of novel water-soluble curcumin formulations and St. John’s wort in behavioral paradigms of despairPharmacology. (2012)
  54. a b c d e f Garcea G, et al. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequencesCancer Epidemiol Biomarkers Prev. (2005)
  55. ^ Mandeville JS, Froehlich E, Tajmir-Riahi HA. Study of curcumin and genistein interactions with human serum albuminJ Pharm Biomed Anal. (2009)
  56. a b c Ireson C, et al. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 productionCancer Res. (2001)
  57. a b c d Vareed SK, et al. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjectsCancer Epidemiol Biomarkers Prev. (2008)
  58. ^ Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the ratXenobiotica. (1978)
  59. ^ Ireson CR, et al. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestineCancer Epidemiol Biomarkers Prev. (2002)
  60. ^ Zhang W, Tan TM, Lim LY. Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in ratsDrug Metab Dispos. (2007)
  61. ^ Romiti N, et al. Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytesLife Sci. (1998)
  62. ^ Hsieh YW, et al. Oral intake of curcumin markedly activated CYP 3A4: in vivo and ex-vivo studiesSci Rep. (2014)
  63. ^ Wang Z, et al. Inhibitory effects of curcumin on activity of cytochrome P450 2C9 enzyme in human and 2C11 in rat liver microsomesDrug Dev Ind Pharm. (2015)
  64. a b Appiah-Opong R, et al. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition productsToxicology. (2007)
  65. ^ Al-Jenoobi FI. Effects of some commonly used Saudi folk herbal medications on the metabolic activity of CYP2C9 in human liver microsomesSaudi Pharm J. (2010)
  66. a b Volak LP, et al. Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitorDrug Metab Dispos. (2008)
  67. ^ Mousa SA. Antithrombotic effects of naturally derived products on coagulation and platelet functionMethods Mol Biol. (2010)
  68. ^ Spolarich AE, Andrews L. An examination of the bleeding complications associated with herbal supplements, antiplatelet and anticoagulant medicationsJ Dent Hyg. (2007)
  69. ^ Ulbricht C, et al. Clinical evidence of herb-drug interactions: a systematic review by the natural standard research collaborationCurr Drug Metab. (2008)
  70. a b Sood A, et al. Potential for interactions between dietary supplements and prescription medicationsAm J Med. (2008)
  71. ^ Liu AC, Zhao LX, Lou HX. Curcumin alters the pharmacokinetics of warfarin and clopidogrel in Wistar rats but has no effect on anticoagulation or antiplatelet aggregationPlanta Med. (2013)
  72. ^ Lee JW, et al. Curcumin hampers the antitumor effect of vinblastine via the inhibition of microtubule dynamics and mitochondrial membrane potential in HeLa cervical cancer cellsPhytomedicine. (2016)
  73. ^ Rahayu SI, Nurdiana N, Santoso S. The effect of curcumin and cotrimoxazole in salmonella typhimurium infection in vivoISRN Microbiol. (2013)
  74. ^ Marathe SA, et al. Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella typhimurium and Salmonella typhiJ Antimicrob Chemother. (2013)
  75. ^ Singh M. Essential fatty acids, DHA and human brainIndian J Pediatr. (2005)
  76. ^ Chen HF, Su HM. Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in lifeJ Nutr Biochem. (2013)
  77. ^ Liu JJ, et al. Omega-3 polyunsaturated fatty acid (PUFA) status in major depressive disorder with comorbid anxiety disordersJ Clin Psychiatry. (2013)
  78. ^ Astarita G, et al. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer’s diseasePLoS One. (2010)
  79. ^ Burdge GC, Calder PC. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adultsReprod Nutr Dev. (2005)
  80. a b c Wu A, et al. Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disordersBiochim Biophys Acta. (2015)
  81. a b c Wang R, et al. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkBBrain Res. (2008)
  82. a b c d e f Matteucci A, et al. Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunitInvest Ophthalmol Vis Sci. (2011)
  83. ^ Chen RW, et al. Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotectionJ Neurochem. (2003)
  84. a b c Matteucci A, et al. Curcumin treatment protects rat retinal neurons against excitotoxicity: effect on N-methyl-D: -aspartate-induced intracellular Ca(2+) increaseExp Brain Res. (2005)
  85. a b c Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognitionExp Neurol. (2006)
  86. ^ Nair SM, et al. Corticosteroid regulation of ion channel conductances and mRNA levels in individual hippocampal CA1 neuronsJ Neurosci. (1998)
  87. a b c Xu Y, et al. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stressNeuropharmacology. (2009)
  88. ^ Skilton MR, et al. Associations between anxiety, depression, and the metabolic syndromeBiol Psychiatry. (2007)
  89. a b Esmaily H, et al. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trialChin J Integr Med. (2015)
  90. ^ Lopresti AL, Hood SD, Drummond PD. Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effectsJ Psychopharmacol. (2012)
  91. ^ Sanmukhani J, et al. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trialPhytother Res. (2014)
  92. ^ Bergman J, et al. Curcumin as an add-on to antidepressive treatment: a randomized, double-blind, placebo-controlled, pilot clinical studyClin Neuropharmacol. (2013)
  93. ^ Lopresti AL, et al. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled studyJ Affect Disord. (2014)
  94. ^ Panahi Y, et al. Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorderPhytother Res. (2015)
  95. ^ Lopresti AL, Drummond PD. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled studyJ Affect Disord. (2017)
  96. ^ Frautschy SA, et al. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathologyNeurobiol Aging. (2001)
  97. ^ Sharma S, et al. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain traumaNeuroscience. (2009)
  98. ^ Yang F, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivoJ Biol Chem. (2005)
  99. a b c Baum L, et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer diseaseJ Clin Psychopharmacol. (2008)
  100. ^ Reinke AA, Gestwicki JE. Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibilityChem Biol Drug Des. (2007)
  101. ^ Ma QL, et al. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcuminJ Neurosci. (2009)
  102. ^ Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo.
  103. ^ A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model.
  104. ^ Gomez-Pinilla F. Collaborative effects of diet and exercise on cognitive enhancementNutr Health. (2011)
  105. ^ Wu A, Ying Z, Gomez-Pinilla F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognitionNeuroscience. (2008)
  106. a b Di Pierro F, et al. Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophenJ Pain Res. (2013)
  107. a b Belcaro G, et al. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritisPanminerva Med. (2010)
  108. a b c Belcaro G, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patientsAltern Med Rev. (2010)
  109. ^ Agarwal KA, et al. Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled studySurg Endosc. (2011)
  110. ^ Morimoto T, et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in ratsJ Clin Invest. (2008)
  111. ^ Storka A, et al. Effect of liposomal curcumin on red blood cells in vitroAnticancer Res. (2013)
  112. ^ Tang W, et al. Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart StudyBMC Cardiovasc Disord. (2007)
  113. a b c d DiSilvestro RA, et al. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged peopleNutr J. (2012)
  114. ^ Fang XD, et al. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aortaClin Exp Pharmacol Physiol. (2009)
  115. ^ Majithiya JB, Balaraman R. Time-dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcuminJ Cardiovasc Pharmacol. (2005)
  116. ^ Sompamit K, et al. Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in miceEur J Pharmacol. (2009)
  117. ^ El-Bassossy HM, et al. Haem oxygenase-1 induction protects against tumour necrosis factor alpha impairment of endothelial-dependent relaxation in rat isolated pulmonary arteryBr J Pharmacol. (2009)
  118. ^ Curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation.
  119. a b c d Akazawa N, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal womenNutr Res. (2012)
  120. ^ Fleenor BS, et al. Curcumin ameliorates arterial dysfunction and oxidative stress with agingExp Gerontol. (2013)
  121. ^ Nakmareong S, et al. Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertensionNaunyn Schmiedebergs Arch Pharmacol. (2011)
  122. ^ Sagiroglu T, et al. Protective effect of curcumin on cyclosporin A-induced endothelial dysfunction, antioxidant capacity, and oxidative damageToxicol Ind Health. (2012)
  123. a b Khajehdehi P, et al. Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled studyJ Ren Nutr. (2012)
  124. a b c d e Pungcharoenkul K, Thongnopnua P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjectsPhytother Res. (2011)
  125. a b c d e Kim T, et al. Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cellsBiochem Biophys Res Commun. (2009)
  126. ^ Hardie DG, Hawley SA. AMP-activated protein kinase: the energy charge hypothesis revisitedBioessays. (2001)
  127. ^ Ikonomov OC, et al. Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effectsEndocrinology. (2002)
  128. ^ Yang X, et al. Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formationArterioscler Thromb Vasc Biol. (2006)
  129. ^ Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subjectIndian J Med Sci. (1972)
  130. a b Kim JH, et al. Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cellsJ Cell Physiol. (2010)
  131. ^ Kang C, Kim E. Synergistic effect of curcumin and insulin on muscle cell glucose metabolismFood Chem Toxicol. (2010)
  132. ^ Pan W, et al. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cellsOncol Rep. (2008)
  133. a b c d e Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesityEndocrinology. (2008)
  134. ^ Yekollu SK, Thomas R, O’Sullivan B. Targeting curcusomes to inflammatory dendritic cells inhibits NF-κB and improves insulin resistance in obese miceDiabetes. (2011)
  135. ^ Chuengsamarn S, et al. Curcumin extract for prevention of type 2 diabetesDiabetes Care. (2012)
  136. ^ Xie XY, et al. Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytesPhytomedicine. (2012)
  137. ^ Soltoff SP, Hedden L. Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cellsAm J Physiol Cell Physiol. (2008)
  138. a b Lee YK, et al. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cellsJ Agric Food Chem. (2009)
  139. a b c Zhao J, et al. Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcuminMol Cell Biochem. (2011)
  140. ^ Nieto-Vazquez I, et al. Insulin resistance associated to obesity: the link TNF-alphaArch Physiol Biochem. (2008)
  141. ^ The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.
  142. ^ Zhang HH, et al. Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMPDiabetes. (2002)
  143. ^ Patton JS, et al. Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cellsProc Natl Acad Sci U S A. (1986)
  144. a b Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticalsAnnu Rev Nutr. (2010)
  145. ^ Ruan H, et al. Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatoryDiabetes. (2002)
  146. ^ Qiao L, Shao J. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complexJ Biol Chem. (2006)
  147. ^ Subauste AR, Burant CF. Role of FoxO1 in FFA-induced oxidative stress in adipocytesAm J Physiol Endocrinol Metab. (2007)
  148. ^ Ciardi C, et al. Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitroBr J Nutr. (2012)
  149. ^ Pongchaidecha A, et al. Effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese ratsNutrition. (2009)
  150. ^ Ejaz A, et al. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL miceJ Nutr. (2009)
  151. ^ Arbiser JL, et al. Curcumin is an in vivo inhibitor of angiogenesisMol Med. (1998)
  152. a b Bank J, Song DH. Curcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal MuscleJ Surg Res. (2011)
  153. ^ Avci G, et al. Curcumin protects against ischemia/reperfusion injury in rat skeletal muscleJ Surg Res. (2012)
  154. ^ Pizzo P, et al. Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cellsJ Cell Mol Med. (2010)
  155. ^ Shinkai Y, Yamamoto C, Kaji T. Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathwayToxicol Sci. (2010)
  156. ^ Sevgiler Y, Karaytug S, Karayakar F. Antioxidative effects of N-acetylcysteine, lipoic acid, taurine, and curcumin in the muscle of Cyprinus carpio L. exposed to cadmiumArh Hig Rada Toksikol. (2011)
  157. ^ Vazeille E, et al. Curcumin treatment prevents increased proteasome and apoptosome activities in rat skeletal muscle during reloading and improves subsequent recoveryJ Nutr Biochem. (2012)
  158. ^ Siddiqui RA, et al. Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing miceBr J Nutr. (2009)
  159. a b Li YP, et al. TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscleFASEB J. (2005)
  160. a b Deng YT, et al. Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cellsJ Agric Food Chem. (2012)
  161. a b c Na LX, et al. Curcumin improves insulin resistance in skeletal muscle of ratsNutr Metab Cardiovasc Dis. (2011)
  162. ^ Cheng TC, et al. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar ratsNeurosci Lett. (2009)
  163. ^ Xavier S, et al. β(2)-Adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: Antagonism by vitamin D(3) and curcuminEur J Pharmacol. (2012)
  164. ^ He HJ, et al. Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed miceWorld J Diabetes. (2012)
  165. ^ Seo KI, et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db miceMol Nutr Food Res. (2008)
  166. ^ Chaudhary A, Bhandari A, Pandurangan A. Antioxidant potential and total phenolic content of methanolic bark extract of Madhuca indica (koenig) GmelinAnc Sci Life. (2012)
  167. ^ Koren E, et al. Supplementation with antioxidants fails to increase the total antioxidant capacity of several cell lines in cultureBiomed Pharmacother. (2008)
  168. ^ Voronin MV, et al. Total antioxidant capacity of blood plasma from healthy donors receiving vitamin and mineral complexBull Exp Biol Med. (2004)
  169. ^ Dominiak K, et al. Critical need for clinical trials: an example of a pilot human intervention trial of a mixture of natural agents protecting lymphocytes against TNF-alpha induced activation of NF-kappaBPharm Res. (2010)
  170. a b c d e Everett PC, et al. Preclinical assessment of curcumin as a potential therapy for B-CLLAm J Hematol. (2007)
  171. ^ Chun KS, et al. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activationCarcinogenesis. (2003)
  172. ^ Kunnumakkara AB, et al. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene productsCancer Res. (2007)
  173. ^ Ponnurangam S, et al. Urine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assayIn Vivo. (2010)
  174. a b Aggarwal S, et al. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activationMol Pharmacol. (2006)
  175. ^ Dileep KV, Tintu I, Sadasivan C. Molecular docking studies of curcumin analogs with phospholipase A2Interdiscip Sci. (2011)
  176. ^ Young NA, et al. Oral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NFκB signaling and macrophage migrationPLoS One. (2014)
  177. ^ Woo HM, et al. Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytesLife Sci. (2007)
  178. ^ Binion DG, et al. Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcuminAm J Physiol Gastrointest Liver Physiol. (2009)
  179. ^ Kumar A, et al. Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activationBiochem Pharmacol. (1998)
  180. ^ Jackson JK, et al. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritisInflamm Res. (2006)
  181. a b Ramadan G, Al-Kahtani MA, El-Sayed WM. Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritisInflammation. (2011)
  182. a b Narayanan A, et al. Curcumin Inhibits Rift Valley Fever Virus Replication in Human CellsJ Biol Chem. (2012)
  183. ^ Karbalay-Doust S, Noorafshan A. Ameliorative effects of curcumin on the spermatozoon tail length, count, motility and testosterone serum level in metronidazole-treated micePrague Med Rep. (2011)
  184. ^ Giannessi F, et al. Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administrationMed Sci Monit. (2008)
  185. ^ Quintans LN, Castro GD, Castro JA. Oxidation of ethanol to acetaldehyde and free radicals by rat testicular microsomesArch Toxicol. (2005)
  186. ^ Chandra AK, et al. Effect of curcumin on chromium-induced oxidative damage in male reproductive systemEnviron Toxicol Pharmacol. (2007)
  187. ^ Aktas C, et al. Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testesToxicol Ind Health. (2012)
  188. a b c Murphy CJ, et al. Reproductive effects of a pegylated curcuminReprod Toxicol. (2012)
  189. a b White EL, et al. Screening of potential cancer preventing chemicals as aromatase inhibitors in an in vitro assayAnticancer Res. (1999)
  190. a b Valentine SP, et al. Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouseLife Sci. (2006)
  191. ^ Folwarczna J, Zych M, Trzeciak HI. Effects of curcumin on the skeletal system in ratsPharmacol Rep. (2010)
  192. ^ Bachmeier BE, et al. Reference profile correlation reveals estrogen-like trancriptional activity of CurcuminCell Physiol Biochem. (2010)
  193. ^ Singh M, Singh N. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cellsMol Cell Biochem. (2011)
  194. ^ Kinoshita A, et al. Carcinogenicity of dimethylarsinic acid in Ogg1-deficient miceCancer Sci. (2007)
  195. ^ Biswas J, et al. Curcumin protects DNA damage in a chronically arsenic-exposed population of West BengalHum Exp Toxicol. (2010)
  196. ^ Mukundan MA, et al. Effect of turmeric and curcumin on BP-DNA adductsCarcinogenesis. (1993)
  197. ^ Sharma RA, et al. Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levelsClin Cancer Res. (2001)
  198. ^ Bhattacharyya S, et al. Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: protection by curcuminCancer Res. (2007)
  199. ^ Deeb D, et al. Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylationMol Cancer Ther. (2004)
  200. ^ Deeb D, et al. Curcumin {1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6} sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathwayJ Pharmacol Exp Ther. (2007)
  201. ^ Song WB, et al. Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activationPLoS One. (2010)
  202. ^ Kim YS, et al. Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cellsJ Cardiovasc Pharmacol. (2007)
  203. ^ Camacho-Barquero L, et al. Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitisInt Immunopharmacol. (2007)
  204. a b c Curcumin Inhibits Prostate Cancer Metastasis in vivo by Targeting the Inflammatory Cytokines CXCL1 and -2.
  205. ^ Chintharlapalli S1, et al. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factorsCancer Res. (2007)
  206. a b c d Chadalapaka G1, et al. Curcumin decreases specificity protein expression in bladder cancer cellsCancer Res. (2008)
  207. ^ Lionaki E, Markaki M, Tavernarakis N. Autophagy and ageing: insights from invertebrate model organismsAgeing Res Rev. (2013)
  208. ^ Markaki M, Tavernarakis N. The role of autophagy in genetic pathways influencing ageingBiogerontology. (2011)
  209. ^ Pallauf K, Rimbach G. Autophagy, polyphenols and healthy ageingAgeing Res Rev. (2013)
  210. a b Wu JC, et al. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cellsMol Nutr Food Res. (2011)
  211. a b Aoki H, et al. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathwaysMol Pharmacol. (2007)
  212. ^ Li B, et al. Curcumin Induces Cross-Regulation Between Autophagy and Apoptosis in Uterine Leiomyosarcoma CellsInt J Gynecol Cancer. (2013)
  213. ^ Kim JY, et al. Curcumin-induced autophagy contributes to the decreased survival of oral cancer cellsArch Oral Biol. (2012)
  214. a b c Liao VH, et al. Curcumin-mediated lifespan extension in Caenorhabditis elegansMech Ageing Dev. (2011)
  215. ^ Zhuang W, et al. Curcumin promotes differentiation of glioma-initiating cells by inducing autophagyCancer Sci. (2012)
  216. ^ Zanotto-Filho A, et al. Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatmentEur J Pharm Biopharm. (2012)
  217. ^ Daido S, et al. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cellsCancer Res. (2004)
  218. ^ Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy.
  219. ^ Jiang TF, et al. Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of MacroautophagyJ Neuroimmune Pharmacol. (2013)
  220. a b c Soh JW, et al. Curcumin is an early-acting stage-specific inducer of extended functional longevity in DrosophilaExp Gerontol. (2013)
  221. ^ Lifespan Extension by the Antioxidant Curcumin in Drosophila Melanogaster.
  222. ^ Lee KS, et al. Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogasterRejuvenation Res. (2010)
  223. a b c Kitani K, Osawa T, Yokozawa T. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 miceBiogerontology. (2007)
  224. ^ Kitani K, Yokozawa T, Osawa T. Interventions in aging and age-associated pathologies by means of nutritional approachesAnn N Y Acad Sci. (2004)
  225. a b Spindler S, et al. Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, Pycnogenol, quercetin and taxifolin fed isocalorically to long-lived, outcrossed miceRejuvenation Res. (2013)
  226. a b Strong R, et al. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous miceJ Gerontol A Biol Sci Med Sci. (2013)
  227. ^ Food Intake, Water Intake, and Drinking Spout Side Preference of 28 Mouse Strains.
  228. ^ Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Healthy Adult Volunteers.
  229. a b Hanai H, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trialClin Gastroenterol Hepatol. (2006)
  230. ^ Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot studyDig Dis Sci. (2005)
  231. ^ Um MY, et al. Curcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMPKBasic Clin Pharmacol Toxicol. (2013)
  232. a b Khajehdehi P, et al. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled studyScand J Urol Nephrol. (2011)
  233. a b Zhong F, et al. Curcumin attenuates lipopolysaccharide-induced renal inflammationBiol Pharm Bull. (2011)
  234. ^ Ghosh SS, et al. Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammationAm J Physiol Renal Physiol. (2009)
  235. ^ Hill-Kapturczak N, et al. Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cellsAm J Physiol Renal Physiol. (2001)
  236. ^ Gaedeke J, Noble NA, Border WA. Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1Kidney Int. (2005)
  237. ^ Sehgal A, et al. Synergistic effects of piperine and curcumin in modulating benzo(a)pyrene induced redox imbalance in mice lungsToxicol Mech Methods. (2012)
  238. ^ Sehgal A, et al. Piperine as an adjuvant increases the efficacy of curcumin in mitigating benzo(a)pyrene toxicityHum Exp Toxicol. (2012)
  239. ^ Sehgal A, et al. Combined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damageFood Chem Toxicol. (2011)
  240. ^ Hlavačková L, et al. Spice up the hypertension diet – curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertensionNutr Metab (Lond). (2011)
  241. ^ Murakami A, et al. Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesisBiofactors. (2013)
  242. ^ Bhagavathula N, et al. A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skinWound Repair Regen. (2009)
  243. ^ Madkor HR, Mansour SW, Ramadan G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic ratsBr J Nutr. (2011)
  244. a b Ide H, et al. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigenProstate. (2010)
  245. ^ Altenburg JD, et al. A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound aloneBMC Cancer. (2011)
  246. ^ Saw CL, Huang Y, Kong AN. Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acidBiochem Pharmacol. (2010)
  247. ^ Baum L, Ng A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal modelsJ Alzheimers Dis. (2004)
  248. ^ Ishihara M, Sakagami H. Re-evaluation of cytotoxicity and iron chelation activity of three beta-diketones by semiempirical molecular orbital methodIn Vivo. (2005)
  249. a b Jiao Y1, et al. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelatorBlood. (2009)
  250. ^ Tuntipopipat S, et al. Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite mealJ Nutr. (2006)
  251. ^ Padhye S, et al. Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogsJ Hematol Oncol. (2009)
  252. ^ Parasramka MA, Gupta SV. Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cellsJ Oncol. (2012)
  253. a b c d Korwek Z, et al. DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cellsMutagenesis. (2013)
  254. ^ National Toxicology Program. NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)Natl Toxicol Program Tech Rep Ser. (1993)
  255. ^ Chin D, et al. Curcumin may impair iron status when fed to mice for six monthsRedox Biol. (2014)
  256. ^ Nakayama H, et al. A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trialNutr J. (2014)
  257. ^ Blasiak J, Trzeciak A, Kowalik J. Curcumin damages DNA in human gastric mucosa cells and lymphocytesJ Environ Pathol Toxicol Oncol. (1999)
  258. ^ Błasiak J, et al. DNA damage and repair in human lymphocytes and gastric mucosa cells exposed to chromium and curcuminTeratog Carcinog Mutagen. (1999)
  259. ^ Sun B, et al. Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcuminToxicol In Vitro. (2013)
  260. ^ Lu HF, et al. Curcumin-induced DNA damage and inhibited DNA repair genes expressions in mouse-rat hybrid retina ganglion cells (N18)Neurochem Res. (2009)
  261. ^ Cao J, et al. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cellsToxicol Sci. (2006)
  262. ^ Huang FJ, et al. Effect of curcumin on in vitro early post-implantation stages of mouse embryo developmentEur J Obstet Gynecol Reprod Biol. (2013)
  263. ^ Chen CC, Chan WH. Injurious effects of curcumin on maturation of mouse oocytes, fertilization and fetal development via apoptosisInt J Mol Sci. (2012)
  264. ^ Ashok P, Meenakshi B. Contraceptive effect of Curcuma longa (L.) in male albino ratAsian J Androl. (2004)
  265. ^ Ganiger S, et al. A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar ratsFood Chem Toxicol. (2007)
  266. ^ Qiu P, et al. Overdose Intake of Curcumin Initiates the Unbalanced State of BodiesJ Agric Food Chem. (2016)
  267. ^ Navarro VJ, et al. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury NetworkHepatology. (2014)
  268. ^ Sharma RA, et al. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and complianceClin Cancer Res. (2004)
  269. ^ Carroll RE, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasiaCancer Prev Res (Phila). (2011)
  270. ^ Burgos-Morón E, et al. The dark side of curcuminInt J Cancer. (2010)
  271. a b Kieć-Swierczyńska M, Krecisz B. Occupational allergic contact dermatitis due to curcumin food colour in a pasta factory workerContact Dermatitis. (1998)
  272. a b Fischer LA, Agner T. Curcumin allergy in relation to yellow chlorhexidine solution used for skin disinfection prior to surgeryContact Dermatitis. (2004)
  273. a b Liddle M, et al. Contact urticaria from curcuminDermatitis. (2006)
  274. a b Hata M, et al. Allergic contact dermatitis from curcumin (turmeric)Contact Dermatitis. (1997)
  275. a b Lamb SR, Wilkinson SM. Contact allergy to tetrahydrocurcuminContact Dermatitis. (2003)
  276. a b Thompson DA, Tan BB. Tetrahydracurcumin-related allergic contact dermatitisContact Dermatitis. (2006)
  277. ^ Horev L, Ramot Y, Klapholz L. Yellow Feet in a Patient with Breast and Thyroid Carcinoma, Due to Oral Intake of TurmericDrug Saf Case Rep. (2015)
  278. ^ Robinson DM. Anaphylaxis to turmericJ Allergy Clin Immunol. (2003)
  279. Panahi Y, et al. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trialPhytother Res. (2014)
  280. Baum L, et al. Curcumin effects on blood lipid profile in a 6-month human studyPharmacol Res. (2007)
  281. Appendino G, et al. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot studyPanminerva Med. (2011)
  282. Chainani-Wu N, et al. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planusJ Am Acad Dermatol. (2012)
  283. Kalpravidh RW, et al. Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoidsClin Biochem. (2010)
  284. Koosirirat C, et al. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patientsInt Immunopharmacol. (2010)
  285. Alwi I, et al. The effect of curcumin on lipid level in patients with acute coronary syndromeActa Med Indones. (2008)
  286. Shimouchi A, et al. Effect of dietary turmeric on breath hydrogenDig Dis Sci. (2009)
  287. Durgaprasad S, et al. A pilot study of the antioxidant effect of curcumin in tropical pancreatitisIndian J Med Res. (2005)
  288. Kuptniratsaikul V, et al. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritisJ Altern Complement Med. (2009)
  289. Wickenberg J, Ingemansson SL, Hlebowicz J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjectsNutr J. (2010)
  290. He ZY, et al. Upregulation of p53 expression in patients with colorectal cancer by administration of curcuminCancer Invest. (2011)
  291. Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trialInflammopharmacology. (2013)
  292. Nakagawa Y, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective studyJ Orthop Sci. (2014)
  293. Haroyan A, et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled studyBMC Complement Altern Med. (2018)
  294. Kuptniratsaikul V, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter studyClin Interv Aging. (2014)
  295. Panda SK, et al. A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OABiomed Res Int. (2018)
  296. Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritisPhytother Res. (2012)
  297. Amalraj A, et al. A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group StudyJ Med Food. (2017)
  298. Choi YH, et al. A randomized, double-blind, placebo-controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivationProstate. (2019)
  299. Kanchanatawan B, et al. Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled StudyNeurotox Res. (2018)
  300. Yu JJ, et al. Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot StudyJ Clin Psychopharmacol. (2015)
  301. Pinsornsak P, Niempoog S. The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trialJ Med Assoc Thai. (2012)
  302. Panahi Y, et al. Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled TrialDrug Res (Stuttg). (2018)
  303. Asadi S, et al. Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo- controlled clinical trialComplement Ther Med. (2019)
  304. Campbell MS, et al. Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trialNutrition. (2019)
  305. Adab Z, et al. Effect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patientsPhytother Res. (2019)
  306. Cicero AFG, et al. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trialEur J Nutr. (2019)
  307. Thota RN, Acharya SH, Garg ML. Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trialLipids Health Dis. (2019)
  308. Na LX, et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trialMol Nutr Food Res. (2013)
  309. Yang H, et al. Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficaciesExp Clin Endocrinol Diabetes. (2015)
  310. Saadati S, et al. The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver diseaseEur J Clin Nutr. (2019)
  311. Thota RN, et al. Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled studySci Rep. (2018)
  312. Ferguson JJA, et al. Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trialMetabolism. (2018)
  313. Navekar R, et al. Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver DiseasesJ Am Coll Nutr. (2017)
  314. Rahimi HR, et al. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trialAvicenna J Phytomed. (2016)
  315. Rahmani S, et al. Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled TrialPhytother Res. (2016)
  316. Panahi Y, et al. Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled TrialJ Cardiovasc Pharmacol. (2016)
  317. Kocher A, et al. Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individualsMol Nutr Food Res. (2016)
  318. Mirzabeigi P, et al. The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled TrialIran J Pharm Res. (2015)
  319. Maithili Karpaga Selvi N, et al. Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic PatientsIndian J Clin Biochem. (2015)
  320. Panahi Y, et al. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysisClin Nutr. (2015)
  321. Kim SW, et al. The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled studyBMC Complement Altern Med. (2013)
  322. Nieman DC, et al. Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approachPlant Foods Hum Nutr. (2012)
  323. Jazayeri-Tehrani SA, et al. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trialNutr Metab (Lond). (2019)
  324. Chuengsamarn S, et al. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem. (2014)
  325. Khayat S, et al. Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trialComplement Ther Med. (2015)
  326. Shep D, et al. Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm studyTrials. (2019)
  327. Srivastava S, et al. Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trialInflammopharmacology. (2016)
  328. Ferguson JJA, et al. Bread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic individuals. A randomised controlled trialFood Funct. (2019)
  329. Adibian M, et al. The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trialPhytother Res. (2019)
  330. T Krishnareddy N, et al. A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled StudyBiomed Res Int. (2018)
  331. Barber-Chamoux N, et al. Substantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled TrialMol Nutr Food Res. (2018)
  332. Panahi Y, et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trialComplement Ther Med. (2017)
  333. Santos-Parker JR, et al. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stressAging (Albany NY). (2017)
  334. Oliver JM, et al. Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled StudyJ Nutr Metab. (2016)
  335. Funamoto M, et al. Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPDInt J Chron Obstruct Pulmon Dis. (2016)
  336. Amin F, et al. Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome – a double blind randomized controlled trial – TAK-MetS trialComplement Ther Med. (2015)
  337. Panahi Y, et al. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trialComplement Ther Med. (2014)
  338. Mohammadi A, et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trialPhytother Res. (2013)
  339. Sugawara J, et al. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot studyAm J Hypertens. (2012)