Aloe Vera

Aloe Vera, Aloe Vera

Aloe Vera is a plant with many different effects. Topically used as burn reliever (specially sunburn), wound healer (even Canker Sores) and as an acne treatment. When orally taken, it can provide various benefits, like digestive help, natural laxative effect, weight control, anti-oxidant, anti-inflammatory and some other functions.

Nutraceutic

  • Origin Plant Based
  • Source Itself
  • Type Amino Acid, Vitamin, Mineral, Phytochemicals, Enzymes, Salicylic Acids
  • Age Range Adults (20-59)
  • Toxicity Toxic in high doses
  • Side effects Nausea, Diarrhea, Abdominal Pain, Hepatotoxic, Cramps
  • Warnings Pregnancy, Hepatic Diseases

Why be Careful

The high concentrations of anthraquinones in Aloe Vera may induce abortion, once it has stimulant effects in the large intestine, that can produce reflexes on uterine muscles. When consumed in excess, anthraquinones can result in severe diarrhea, cramps and nausea. Chronic use of Aloe Vera is also associated with severe acute hepatitis when consumed in high doses (250-500mg a day) for as long as 4 weeks. All the cases in literature confirm that the disease is reverted within weeks after Aloe Vera intake is suspended. Note that all cases were diagnosed before any complications.

References

  1. a b c d e Vinson JA, Al Kharrat H, Andreoli L. Effect of Aloe vera preparations on the human bioavailability of vitamins C and EPhytomedicine. (2005)
  2. a b Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice ExtractInt J Toxicol. (2007)
  3. ^ Isolation and purification of aloe anthraquinones based on an ionic liquid/salt aqueous two-phase system.
  4. ^ Nema NK, et al. Determination of trace and heavy metals in some commonly used medicinal herbs in AyurvedaToxicol Ind Health. (2012)
  5. ^ Coopoosamy RM, Naidoo KK. A Comparative Study of Three Aloe Species Used to Treat Skin Diseases in South African Rural CommunitiesJ Altern Complement Med. (2012)
  6. a b c Fanali S, et al. Analysis of Aloe-based phytotherapeutic products by using nano-LC-MSJ Sep Sci. (2010)
  7. ^ Kuzuya H, et al. Determination of aloenin, barbaloin and isobarbaloin in aloe species by micellar electrokinetic chromatographyJ Chromatogr B Biomed Sci Appl. (2001)
  8. ^ Locatelli M. Anthraquinones: analytical techniques as a novel tool to investigate on the triggering of biological targetsCurr Drug Targets. (2011)
  9. a b Pugh N, et al. Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activityJ Agric Food Chem. (2001)
  10. ^ Rodríguez Rodríguez E, Darias Martín J, Díaz Romero C. Aloe vera as a functional ingredient in foodsCrit Rev Food Sci Nutr. (2010)
  11. a b c Shin E, et al. Dietary Aloe Reduces Adipogenesis via the Activation of AMPK and Suppresses Obesity-related Inflammation in Obese MiceImmune Netw. (2011)
  12. ^ Yagi A, et al. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe veraPlanta Med. (2002)
  13. ^ Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice.
  14. ^ Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a Polysaccharide Extracted from Aloe vera, Is Effective in the Treatment of Oral Aphthous UlcerationJ Altern Complement Med. (2012)
  15. ^ Babaee N, et al. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitisDent Res J (Isfahan). (2012)
  16. a b Saito M, et al. Aloe vera Gel Extract Attenuates Ethanol-Induced Hepatic Lipid Accumulation by Suppressing the Expression of Lipogenic Genes in MiceBiosci Biotechnol Biochem. (2012)
  17. ^ Bottenberg MM, et al. Oral aloe vera-induced hepatitisAnn Pharmacother. (2007)
  18. ^ Yang HN, et al. Aloe-induced toxic hepatitisJ Korean Med Sci. (2010)
  19. ^ Jiménez-Encarnación E, et al. Euforia-induced acute hepatitis in a patient with sclerodermaBMJ Case Rep. (2012)