Serenoa Repens, Saw Palmetto

Saw palmetto is a supplement derived from the fruit of the Serenoa repens plant. This plant is a small palm tree native to North America and its extracts are used medicinally as an antiandrogen and antiedematous. The saw palmetto supplement has a caloric value, as it is a mixture of fatty acids. The fatty acids found in the fruit have the ability to block an enzyme that converts the hormone testosterone to dihydrotestosterone (the most androgenic form), which can cause hair loss. Saw palmetto supplementation has also been used for benign prostatic hyperplasia (BPH) and urinary tract symptoms.

  • Origin: Plant Based
  • Source: Itself
  • Type: Fatty Acid
  • Age Range: Adults (18-60)
  • Toxicity: May be toxic in high doses
  • Outcomes: Hormone Regulation, Testosterone, Longevity & Anti-Aging, Overall Well-Being

What are Saw Palmetto benefits?

Texto Benefits

Table of relations

Consistent effects
Strength of effects
Scientific articles
Hormone Regulation Hormone Regulation
Longevity & Anti-Aging Longevity & Anti-Aging

Hormone Regulation Saw Palmetto and Hormone Regulation

Hormones are chemical substances synthesized by the body to act as cellular signalers. Hormones' main function is to work by regulating growth, development, reproduction and the functions of many tissues, as well as the metabolic processes of the organism. It is important to maintain good levels of all hormones, as any change can result in different kinds of dysfunction. Supplements that help regulate hormones work in different ways, which can increase their synthesis and secretion or even intervene in positive and negative feedbacks in the body.
  • Testosterone

    Testosterone is the main male sex hormone. It is responsible for regulating fertility, muscle mass, fat distribution and the production of red blood cells. Women's ovaries also produce testosterone, although in much smaller quantities.

Longevity & Anti-Aging Saw Palmetto and Longevity & Anti-Aging

To live longer is necessary to live well, meaning that overall well-being, healthy organs, a healthy brain and good habits are taken into consideration when it comes to longevity. All of those circumstances require a healthy lifestyle, which works directly in the prevention of illnesses or conditions that might negatively influence your health. There are a lot nutraceutics and supplements that can help the body to stay safe and sound, just as it should be.
  • Overall Well-Being

    Well-being is related to one's ability to achieve needs and be satisfied with life. It is considered that, for an individual to be healthy, must live the most complete state of physical, mental and social well-being.

Table of negative interactions

Carbonyl Iron, Chlorotrianisene, Conjugated Estrogens, Dienestrol Topical, Esterified Estrogens, Estradiol, Estrone, Estropipate, Ethinyl Estradiol, Ferrous Fumarate, Ferrous Gluconate, Ferrous Sulfate, Heme Iron Polypeptide, Quinestrol

Related videos about Saw Palmetto


  1. a b Prager N1, et al. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopeciaJ Altern Complement Med. (2002)
  2. a b Anderson ML1. Evaluation of Resettin® on serum hormone levels in sedentary malesJ Int Soc Sports Nutr. (2014)
  3. a b c Morgia G1, et al. Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double-blinded randomized study between single or combination therapy (PROCOMB trial)Prostate. (2014)
  4. ^ Ernst E. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John’s Wort, Ginseng, Echinacea, Saw Palmetto, and KavaAnn Intern Med. (2002)
  5. a b c d e De Monte C, et al. Modern extraction techniques and their impact on the pharmacological profile of Serenoa repens extracts for the treatment of lower urinary tract symptomsBMC Urol. (2014)
  6. a b c d e f g h i j k l m n o p q r s t u Schantz MM1, et al. Development of saw palmetto (Serenoa repens) fruit and extract standard reference materialsAnal Bioanal Chem. (2008)
  7. a b c d e f Weisser H1, et al. Effects of the sabal serrulata extract IDS 89 and its subfractions on 5 alpha-reductase activity in human benign prostatic hyperplasiaProstate. (1996)
  8. a b c d e f g h i j k l m n o Abe M, et al. Isolation and pharmacological characterization of fatty acids from saw palmetto extractAnal Sci. (2009)
  9. ^ Abe M, et al. Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extractBiol Pharm Bull. (2009)
  10. a b c d e f g h i Habib FK1, et al. Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expressionInt J Cancer. (2005)
  11. a b Goepel M1, et al. Saw palmetto extracts potently and noncompetitively inhibit human alpha1-adrenoceptors in vitroProstate. (1999)
  12. a b c d e f g Suzuki M1, et al. Muscarinic and alpha 1-adrenergic receptor binding characteristics of saw palmetto extract in rat lower urinary tractUrology. (2007)
  13. ^ Takahashi D, et al. Structure-activity relationships of receptor binding of 1,4-dihydropyridine derivativesBiol Pharm Bull. (2008)
  14. a b c Suzuki M1, et al. Pharmacological effects of saw palmetto extract in the lower urinary tractActa Pharmacol Sin. (2009)
  15. a b Strauch G1, et al. Comparison of finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteersEur Urol. (1994)
  16. ^ Albassam AA1, Mohamed ME, Frye RF. Inhibitory effect of six herbal extracts on CYP2C8 enzyme activity in human liver microsomesXenobiotica. (2014)
  17. ^ Chittur S1, Parr B, Marcovici G. Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic Acid and saw palmetto extractEvid Based Complement Alternat Med. (2011)
  18. ^ Latil A1, et al. Hexanic lipidosterolic extract of Serenoa repens inhibits the expression of two key inflammatory mediators, MCP-1/CCL2 and VCAM-1, in vitroBJU Int. (2012)
  19. ^ Sirab N1, et al. Lipidosterolic extract of serenoa repens modulates the expression of inflammation related-genes in benign prostatic hyperplasia epithelial and stromal cellsInt J Mol Sci. (2013)
  20. ^ Iehlé C1, et al. Human prostatic steroid 5 alpha-reductase isoforms–a comparative study of selective inhibitorsJ Steroid Biochem Mol Biol. (1995)
  21. ^ Liang T1, Liao S. Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acidsBiochem J. (1992)
  22. a b c Bayne CW1, et al. Serenoa repens (Permixon): a 5alpha-reductase types I and II inhibitor-new evidence in a coculture model of BPHProstate. (1999)
  23. ^ Délos S1, et al. Testosterone metabolism in primary cultures of human prostate epithelial cells and fibroblastsJ Steroid Biochem Mol Biol. (1995)
  24. ^ Sultan C, et al. Inhibition of androgen metabolism and binding by a liposterolic extract of “Serenoa repens B” in human foreskin fibroblastsJ Steroid Biochem. (1984)
  25. ^ Brown GA1, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young menInt J Sport Nutr Exerc Metab. (2000)
  26. ^ Brown GA1, et al. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old menJ Am Coll Nutr. (2001)
  27. ^ Kohut ML1, et al. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged menJ Am Coll Nutr. (2003)
  28. ^ Brown GA1, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old menInt J Vitam Nutr Res. (2001)
  29. a b c Bertaccini A1, et al. Observational database serenoa repens (DOSSER): overview, analysis and results. A multicentric SIUrO (Italian Society of Oncological Urology) projectArch Ital Urol Androl. (2012)
  30. ^ Jane EP1, et al. Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cellsJ Pharmacol Exp Ther. (2014)
  31. ^ Castellino RC1, Durden DL. Mechanisms of disease: the PI3K-Akt-PTEN signaling node–an intercept point for the control of angiogenesis in brain tumorsNat Clin Pract Neurol. (2007)
  32. ^ Yang Y1, et al. Effect of saw palmetto extract on PI3K cell signaling transduction in human gliomaExp Ther Med. (2014)
  33. a b Silvestri I1, et al. Effect of Serenoa repens (Permixon®) on the expression of inflammation-related genes: analysis in primary cell cultures of human prostate carcinomaJ Inflamm (Lond). (2013)
  34. ^ Marks LS1, et al. PC-SPES: herbal formulation for prostate cancerUrology. (2002)
  35. a b Ng AC, Cheng KF, Leung PC1. Prospective Trial of an Herbal Formula BYSH and Saw Palmetto in Patients with Hormonal Refractory Prostate Cancer: A Pilot StudyRecent Pat Inflamm Allergy Drug Discov. (2014)
  36. ^ Bayne EK1, et al. Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalpBr J Dermatol. (1999)
  37. ^ Boersma IH, et al. The effectiveness of finasteride and dutasteride used for 3 years in women with androgenetic alopeciaIndian J Dermatol Venereol Leprol. (2014)
  38. ^ Sato A1, Takeda A. Evaluation of efficacy and safety of finasteride 1 mg in 3177 Japanese men with androgenetic alopeciaJ Dermatol. (2012)
  39. ^ Gubelin Harcha W1, et al. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopeciaJ Am Acad Dermatol. (2014)
  40. ^ Olsen EA1, et al. The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasterideJ Am Acad Dermatol. (2006)
  41. ^ Rossi A, et al. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year studyInt J Immunopathol Pharmacol. (2012)
  42. ^ Lepor H, et al. The efficacy of terazosin, finasteride, or both in benign prostatic hyperplasia. Veterans Affairs Cooperative Studies Benign Prostatic Hyperplasia Study GroupN Engl J Med. (1996)
  43. ^ Montgomery BT1, et al. Hormonal regulation of prostate-specific antigen (PSA) glycoprotein in the human prostatic adenocarcinoma cell line, LNCaPProstate. (1992)
  44. ^ Wilt TJ, et al. Phytotherapy for benign prostatic hyperplasiaPublic Health Nutr. (2000)
  45. ^ Champault G, Patel JC, Bonnard AM. A double-blind trial of an extract of the plant Serenoa repens in benign prostatic hyperplasiaBr J Clin Pharmacol. (1984)
  46. ^ Ryu YW1, et al. Comparison of Tamsulosin Plus Serenoa Repens with Tamsulosin in the Treatment of Benign Prostatic Hyperplasia in Korean Men: 1-Year Randomized Open Label StudyUrol Int. (2015)
  47. a b Tacklind J1, et al. Serenoa repens for benign prostatic hyperplasiaCochrane Database Syst Rev. (2009)
  48. ^ Wilt T1, Ishani A, Mac Donald R. Serenoa repens for benign prostatic hyperplasiaCochrane Database Syst Rev. (2002)
  49. ^ Gerber GS1, et al. Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptomsUrology. (2001)
  50. ^ Bent S1, et al. Saw palmetto for benign prostatic hyperplasiaN Engl J Med. (2006)
  51. ^ Tacklind J, et al. Serenoa repens for benign prostatic hyperplasiaCochrane Database Syst Rev. (2012)
  52. ^ Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactionsArch Intern Med. (1998)
  53. ^ Agbabiaka TB, et al. Serenoa repens (saw palmetto): a systematic review of adverse eventsDrug Saf. (2009)
  54. ^ Jibrin I, et al. Saw palmetto-induced pancreatitisSouth Med J. (2006)
  55. ^ Wargo KA, Allman E, Ibrahim F. A possible case of saw palmetto-induced pancreatitisSouth Med J. (2010)
  56. ^ Lapi F, et al. Acute liver damage due to Serenoa repens: a case reportBr J Clin Pharmacol. (2010)
  57. ^ Miroddi M1, et al. Hot flashes in a young girl: a wake-up call concerning Serenoa repens use in childrenPediatrics. (2012)
  58. a b Morabito P, et al. Serenoa repens as an Endocrine Disruptor in a 10-Year-Old Young Girl: A New Case ReportPharmacology. (2015)
  59. MacDonald R, et al. Serenoa repens monotherapy for benign prostatic hyperplasia (BPH): an updated Cochrane systematic reviewBJU Int. (2012)
  60. Willetts KE, et al. Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trialBJU Int. (2003)
  61. Hizli F, Uygur MC. A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasiaInt Urol Nephrol. (2007)
  62. Suter A, et al. Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trialPhytother Res. (2013)
  63. Andriole GL, et al. The effect of increasing doses of saw palmetto fruit extract on serum prostate specific antigen: analysis of the CAMUS randomized trialJ Urol. (2013)
  64. Barry MJ, et al. Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trialJAMA. (2011)