Muscle Gain
Muscle Health

Muscle Gain

Muscle gain, also called hypertrophy, occurs when muscle cells receive a kind of stimulation that generates microlesions. For the healing of these lesions there is an increase in protein synthesis, which gives the muscle a larger volume. This occurs with the aid of a positive calorie balance (more calories consumed than spent). Supplements that increase muscle mass promote resistance and affect the rate of synthesis and breakdown of muscle proteins directly or indirectly.

Table of relations

Nutraceutical
Consistent effects
Strength of effects
Scientific articles
Notes
Beta-alanine seems to possess a hypertrophic effect, either inherently or through greater workload, but this effect doesn't appear overly potent.
There seems to be a distinction between acute and chronic supplementation; whereas acute citrulline supplementation doesn't seem to reliably improve performance, the studies that gave citrulline for every week before testing saw improvements. Additionally, a meta-analysis found alittle but statistically significant increase for studies overall.
Does appear to possess inherent lean mass building properties, but an outsized amount of research is confounded with water weight gains (difficult to assess potency).