Depression
Energy and Mood

Depression

Depression is a chronic and recurrent psychiatric condition that produces mood changes characterized by deep sadness, mood swings, loss of interest in activities, causing significant impairment in daily life.

Table of relations

Nutraceutical
Consistent effects
Strength of effects
Scientific articles
Notes
One very preliminary study exists, but remission was achieved altogether three subjects with 2-3g agmatine.
Antidepressive effects are found with ashwagandha, although they're less notable than the anti-anxiety effects. they'll be mediated by similar mechanisms.
Curcumin seems to be simpler than placebo in reducing symptoms of depression. it's going to take 2-3 months to ascertain any outcomes. Skepticism is warranted though, because the studies comparing curcumin to placebo weren't neat and produced effect sizes not too far apart, albeit the differences were statistically significant.
There appears to be a discount in depressive symptoms related to inositol supplementation, although it's less potent than the advantages of inositol on anxiety and panic attacks.
Depressive symptoms are reduced vicariously through reductions in anxiety; intrinsically antidepressant effects of kava uncertain.
Reduced depressive symptoms are found in elderly diabetics.
Fish oil supplementation has been noted to be like pharmaceutical drugs (fluoxetine) in majorly depressed persons, but this could be the only cohort that experiences a reduction of depression. there's insufficient evidence to support a reduction of depressive symptoms in persons with minor depression (ie. not diagnosed major depressive disorder).
Evidence is fairly mixed, but generally supports a discount, but more studies in major depression are specifically needed to guage its efficacy.
Has been noted to reinforce SSRI therapy (similar to creatine) and monotherapy with SAMe appears to be of comparable potency to tricyclic antidepressants for a few studies.
One randomized, controlled trial in 40 depressed patients found a modest but non-significant (p=0.06) reduction in Beck-II score compared with placebo after supplementation of fifty,000 IU of vitamin D once at the beginning of an 8 week period.